YOR269W / PAC1

Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR269W / PAC1

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:2.71|P-value:5.20E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.22|P-value:1.64E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.78|P-value:3.45E-4 ID:SGTC_443|Compound:clozapine|FD-Score:2.99|P-value:1.53E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.83|P-value:1.72E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.57|P-value:6.40E-6 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.81|P-value:2.92E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:2.80|P-value:3.58E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.84|P-value:2.55E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-2.63|P-value:6.55E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.00|P-value:1.22E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.40|P-value:1.91E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.75|P-value:3.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.12|P-value:6.78E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.90|P-value:1.95E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.83|P-value:1.72E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.71|P-value:5.18E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.67|P-value:5.44E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.98|P-value:1.56E-4 ID:SGTC_1809|Compound:st050081|FD-Score:2.59|P-value:8.76E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.40|P-value:1.97E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.00|P-value:1.42E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.65|P-value:6.72E-4 ID:SGTC_1892|Compound:st058411|FD-Score:2.75|P-value:4.41E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.56|P-value:9.77E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.15|P-value:6.09E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.25|P-value:3.53E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.62|P-value:7.63E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.52|P-value:8.67E-6 ID:SGTC_2179|Compound:6298986|FD-Score:2.66|P-value:6.56E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.83|P-value:3.09E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.79|P-value:3.24E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-2.79|P-value:3.27E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.08|P-value:3.27E-7 ID:SGTC_2404|Compound:5161160|FD-Score:3.22|P-value:4.93E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-2.55|P-value:9.07E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.40|P-value:1.95E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:3.98E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.55|P-value:8.88E-6 ID:SGTC_2585|Compound:alliin|FD-Score:3.08|P-value:9.97E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-2.79|P-value:3.21E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-3.42|P-value:1.48E-5 ID:SGTC_2700|Compound:st077718|FD-Score:-3.99|P-value:5.63E-7 ID:SGTC_2711|Compound:st079103|FD-Score:-2.88|P-value:2.13E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.56|P-value:8.63E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.28|P-value:7.81E-11 ID:SGTC_2941|Compound:9056145|FD-Score:2.99|P-value:1.47E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-2.57|P-value:8.36E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.23|P-value:4.63E-5 ID:SGTC_3209|Compound:9113616|FD-Score:2.92|P-value:2.06E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.71|P-value:4.69E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.47|P-value:2.98E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:2.71|P-value:5.20E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.22|P-value:1.64E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.78|P-value:3.45E-4 ID:SGTC_443|Compound:clozapine|FD-Score:2.99|P-value:1.53E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.83|P-value:1.72E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.57|P-value:6.40E-6 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.81|P-value:2.92E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:2.80|P-value:3.58E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-2.84|P-value:2.55E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-2.63|P-value:6.55E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.00|P-value:1.22E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.40|P-value:1.91E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.75|P-value:3.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.12|P-value:6.78E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-2.90|P-value:1.95E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.83|P-value:1.72E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.71|P-value:5.18E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.67|P-value:5.44E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.98|P-value:1.56E-4 ID:SGTC_1809|Compound:st050081|FD-Score:2.59|P-value:8.76E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.40|P-value:1.97E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.00|P-value:1.42E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.65|P-value:6.72E-4 ID:SGTC_1892|Compound:st058411|FD-Score:2.75|P-value:4.41E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.56|P-value:9.77E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.15|P-value:6.09E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.25|P-value:3.53E-5 ID:SGTC_2103|Compound:5378138|FD-Score:2.62|P-value:7.63E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.52|P-value:8.67E-6 ID:SGTC_2179|Compound:6298986|FD-Score:2.66|P-value:6.56E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.83|P-value:3.09E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-2.79|P-value:3.24E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-2.79|P-value:3.27E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.08|P-value:3.27E-7 ID:SGTC_2404|Compound:5161160|FD-Score:3.22|P-value:4.93E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-2.55|P-value:9.07E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.40|P-value:1.95E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:3.98E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.55|P-value:8.88E-6 ID:SGTC_2585|Compound:alliin|FD-Score:3.08|P-value:9.97E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-2.79|P-value:3.21E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-3.42|P-value:1.48E-5 ID:SGTC_2700|Compound:st077718|FD-Score:-3.99|P-value:5.63E-7 ID:SGTC_2711|Compound:st079103|FD-Score:-2.88|P-value:2.13E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-2.56|P-value:8.63E-4 ID:SGTC_2809|Compound:7964133|FD-Score:5.28|P-value:7.81E-11 ID:SGTC_2941|Compound:9056145|FD-Score:2.99|P-value:1.47E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-2.57|P-value:8.36E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.23|P-value:4.63E-5 ID:SGTC_3209|Compound:9113616|FD-Score:2.92|P-value:2.06E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.71|P-value:4.69E-4 ID:SGTC_3219|Compound:9131112|FD-Score:4.47|P-value:2.98E-8

Top fitness defect scores for YOR269W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2809 7964133 5.28 13.0 µM 7.81E-11 60S ribosome export 11 6.48E-8
2 SGTC_3219 9131112 4.47 49.5 µM 2.98E-8 Golgi 30 3.84E-6
3 SGTC_145 3737-0113 4.22 38.4 µM 1.64E-7 DNA intercalators 66 1.24E-5
4 SGTC_1137 ixabepilone 3.83 100.0 µM 1.72E-6 29 6.28E-5
5 SGTC_453 enantio-paf c16 3.83 10.0 µM 1.72E-6 154 6.29E-5
6 SGTC_2551 apiole 3.55 73.9 µM 8.88E-6 14 1.96E-4
7 SGTC_833 3852-0053 3.40 558.0 µM 1.91E-5 36 3.33E-4
8 SGTC_2413 inermin 3.40 26.1 µM 1.95E-5 82 3.38E-4
9 SGTC_1853 st056710 3.40 91.2 µM 1.97E-5 amide catabolism 49 3.41E-4
10 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.26 3.7 µM 3.98E-5 155 5.55E-4
11 SGTC_3207 9114163 3.23 49.5 µM 4.63E-5 64 6.16E-4
12 SGTC_2404 5161160 3.22 200.0 µM 4.93E-5 39 6.44E-4
13 SGTC_2585 alliin 3.08 100.0 µM 9.97E-5 75 0.00105
14 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.00 62.6 µM 1.42E-4 TSC3-RPN4 43 0.00135
15 SGTC_2941 9056145 2.99 11.2 µM 1.47E-4 43 0.00138
16 SGTC_443 clozapine 2.99 122.0 µM 1.53E-4 NEO1-PIK1 27 0.00141
17 SGTC_1176 0848-0131 2.98 83.3 µM 1.56E-4 Golgi 61 0.00143
18 SGTC_3209 9113616 2.92 49.5 µM 2.06E-4 88 0.00175
19 SGTC_2254 7938975 2.83 95.2 µM 3.09E-4 116 0.00231
20 SGTC_662 k832-1615 2.80 104.0 µM 3.58E-4 83 0.00256

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.41E-28 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.185 3.96E-27 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.183 9.19E-27 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.169 5.86E-23 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.166 3.38E-22 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.155 1.61E-19 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.144 4.77E-17 YML038C YMD8 hom Putative nucleotide sugar transporter, has similarity to Vrg4p
0.140 3.48E-16 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.140 4.11E-16 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.140 4.58E-16 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.139 7.62E-16 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.136 2.57E-15 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.134 6.37E-15 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.131 2.40E-14 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.130 4.07E-14 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication