YOR301W / RAX1

Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR301W / RAX1

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-2.48|P-value:8.39E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.52|P-value:7.79E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.55|P-value:6.84E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.61|P-value:4.79E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:2.85|P-value:1.73E-4 ID:SGTC_442|Compound:cape|FD-Score:-2.72|P-value:2.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.99|P-value:1.63E-10 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.65|P-value:3.89E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-2.86|P-value:1.42E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.89|P-value:1.23E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:2.66|P-value:4.21E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:2.61|P-value:5.23E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:2.68|P-value:3.80E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.57|P-value:3.11E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.66|P-value:3.68E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-2.84|P-value:1.56E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-2.70|P-value:3.04E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-4.77|P-value:7.88E-10 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.54|P-value:7.14E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.66|P-value:3.74E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.54|P-value:1.27E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.75|P-value:9.26E-10 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.25|P-value:1.95E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-2.64|P-value:4.10E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-2.88|P-value:1.30E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.11|P-value:4.10E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.68|P-value:1.59E-6 ID:SGTC_1741|Compound:st038134|FD-Score:2.76|P-value:2.68E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.23|P-value:2.11E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.09|P-value:5.05E-5 ID:SGTC_2355|Compound:9061122|FD-Score:4.20|P-value:6.21E-8 ID:SGTC_2356|Compound:9061756|FD-Score:2.71|P-value:3.40E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.42|P-value:8.48E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:2.97|P-value:9.31E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.75|P-value:1.19E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.91|P-value:3.84E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.64|P-value:4.56E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-2.53|P-value:6.57E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.09|P-value:5.27E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.03|P-value:7.06E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-2.61|P-value:4.75E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.57|P-value:5.59E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.97|P-value:8.20E-5 ID:SGTC_3160|Compound:9100216|FD-Score:2.51|P-value:8.27E-4 ID:SGTC_3176|Compound:9106582|FD-Score:2.89|P-value:1.39E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.48|P-value:8.39E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:2.52|P-value:7.79E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.55|P-value:6.84E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.61|P-value:4.79E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:2.85|P-value:1.73E-4 ID:SGTC_442|Compound:cape|FD-Score:-2.72|P-value:2.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.99|P-value:1.63E-10 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-2.65|P-value:3.89E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-2.86|P-value:1.42E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-2.89|P-value:1.23E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:2.66|P-value:4.21E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:2.61|P-value:5.23E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:2.68|P-value:3.80E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.57|P-value:3.11E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.66|P-value:3.68E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-2.84|P-value:1.56E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-2.70|P-value:3.04E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-4.77|P-value:7.88E-10 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.54|P-value:7.14E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.66|P-value:3.74E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.54|P-value:1.27E-12 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.75|P-value:9.26E-10 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.25|P-value:1.95E-5 ID:SGTC_1518|Compound:st038567|FD-Score:-2.64|P-value:4.10E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-2.88|P-value:1.30E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.11|P-value:4.10E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.68|P-value:1.59E-6 ID:SGTC_1741|Compound:st038134|FD-Score:2.76|P-value:2.68E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.23|P-value:2.11E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.09|P-value:5.05E-5 ID:SGTC_2355|Compound:9061122|FD-Score:4.20|P-value:6.21E-8 ID:SGTC_2356|Compound:9061756|FD-Score:2.71|P-value:3.40E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.42|P-value:8.48E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:2.97|P-value:9.31E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.75|P-value:1.19E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.91|P-value:3.84E-7 ID:SGTC_2690|Compound:usnic acid|FD-Score:2.64|P-value:4.56E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-2.53|P-value:6.57E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.09|P-value:5.27E-5 ID:SGTC_2989|Compound:9073649|FD-Score:3.03|P-value:7.06E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-2.61|P-value:4.75E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.57|P-value:5.59E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.97|P-value:8.20E-5 ID:SGTC_3160|Compound:9100216|FD-Score:2.51|P-value:8.27E-4 ID:SGTC_3176|Compound:9106582|FD-Score:2.89|P-value:1.39E-4

Top fitness defect scores for YOR301W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 4.99 10.0 µM 1.63E-10 87 2.95E-7
2 SGTC_2355 9061122 4.20 103.1 µM 6.21E-8 10 1.32E-5
3 SGTC_2621 lithochol-11-enic acid 3.75 100.0 µM 1.19E-6 30 8.79E-5
4 SGTC_2448 5185112 3.42 27.2 µM 8.48E-6 20 3.11E-4
5 SGTC_2353 9059630 3.09 146.7 µM 5.05E-5 41 9.87E-4
6 SGTC_2917 7979103 3.09 53.8 µM 5.27E-5 71 0.00101
7 SGTC_2989 9073649 3.03 71.4 µM 7.06E-5 92 0.00123
8 SGTC_2606 farnesol 2.97 9.8 µM 9.31E-5 71 0.00147
9 SGTC_3176 9106582 2.89 49.5 µM 1.39E-4 9 0.00191
10 SGTC_425 3825-7017 2.85 13.1 µM 1.73E-4 94 0.00220
11 SGTC_1741 st038134 2.76 10.2 µM 2.68E-4 99 0.00293
12 SGTC_2356 9061756 2.71 189.0 µM 3.40E-4 51 0.00341
13 SGTC_811 0416-0114 2.68 265.0 µM 3.80E-4 101 0.00367
14 SGTC_571 k831-0106 2.66 44.2 µM 4.21E-4 81 0.00392
15 SGTC_2690 usnic acid 2.64 100.0 µM 4.56E-4 110 0.00413
16 SGTC_674 0498-0004 2.61 451.0 µM 5.23E-4 heme requiring 96 0.00452
17 SGTC_400 oxethazaine 2.55 37.5 µM 6.84E-4 calcium & mitochondrial duress 95 0.00539
18 SGTC_1262 0737-0114 2.54 49.6 µM 7.14E-4 121 0.00554
19 SGTC_310 1273-0058 2.52 1.1 µM 7.79E-4 mitochondrial stress 437 0.00587
20 SGTC_3160 9100216 2.51 49.5 µM 8.27E-4 55 0.00610

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.332 2.57E-87 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.328 5.16E-85 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.315 7.80E-78 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.314 1.01E-77 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.305 9.87E-73 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.300 1.20E-70 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.295 2.10E-68 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.285 6.99E-64 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.278 2.23E-60 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.263 4.30E-54 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.257 1.18E-51 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.257 1.30E-51 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.255 9.42E-51 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.253 3.29E-50 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.253 3.57E-50 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain