YOR306C / MCH5

Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR306C / MCH5

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:4.11|P-value:2.60E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.88|P-value:6.18E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.25|P-value:1.63E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.10|P-value:3.03E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:2.80|P-value:9.64E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.28|P-value:1.18E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.28|P-value:1.02E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.40|P-value:7.10E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.88|P-value:8.53E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.01|P-value:4.35E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.71|P-value:1.98E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:2.90|P-value:6.62E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:2.83|P-value:8.80E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.26|P-value:1.57E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.00|P-value:4.50E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.14|P-value:2.54E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.30|P-value:1.29E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.89|P-value:8.16E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.41|P-value:7.84E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.10|P-value:2.61E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.10|P-value:2.98E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.62|P-value:3.09E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-2.83|P-value:7.68E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-2.91|P-value:5.55E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.18|P-value:4.44E-9 ID:SGTC_1734|Compound:st037168|FD-Score:2.80|P-value:9.72E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.75|P-value:1.61E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.29|P-value:1.34E-4 ID:SGTC_1859|Compound:st055998|FD-Score:2.90|P-value:6.59E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-2.99|P-value:4.11E-4 ID:SGTC_1938|Compound:st074717|FD-Score:4.17|P-value:1.92E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.27|P-value:1.48E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.26|P-value:1.51E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-2.94|P-value:4.96E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.44|P-value:7.07E-5 ID:SGTC_2371|Compound:9071574|FD-Score:-2.84|P-value:7.31E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.09|P-value:3.10E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:2.88|P-value:7.35E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.20|P-value:1.69E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.09|P-value:3.17E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.20|P-value:1.67E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.41|P-value:6.82E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.11|P-value:2.60E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:-2.88|P-value:6.18E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.25|P-value:1.63E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.10|P-value:3.03E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:2.80|P-value:9.64E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.28|P-value:1.18E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.28|P-value:1.02E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.40|P-value:7.10E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.88|P-value:8.53E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.01|P-value:4.35E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.71|P-value:1.98E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:2.90|P-value:6.62E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:2.83|P-value:8.80E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.26|P-value:1.57E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.00|P-value:4.50E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.14|P-value:2.54E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.30|P-value:1.29E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.89|P-value:8.16E-6 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.41|P-value:7.84E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.10|P-value:2.61E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.10|P-value:2.98E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.62|P-value:3.09E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-2.83|P-value:7.68E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-2.91|P-value:5.55E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.18|P-value:4.44E-9 ID:SGTC_1734|Compound:st037168|FD-Score:2.80|P-value:9.72E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.75|P-value:1.61E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.29|P-value:1.34E-4 ID:SGTC_1859|Compound:st055998|FD-Score:2.90|P-value:6.59E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-2.99|P-value:4.11E-4 ID:SGTC_1938|Compound:st074717|FD-Score:4.17|P-value:1.92E-6 ID:SGTC_1971|Compound:st069429|FD-Score:3.27|P-value:1.48E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.26|P-value:1.51E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-2.94|P-value:4.96E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.44|P-value:7.07E-5 ID:SGTC_2371|Compound:9071574|FD-Score:-2.84|P-value:7.31E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.09|P-value:3.10E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:2.88|P-value:7.35E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.20|P-value:1.69E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.09|P-value:3.17E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.20|P-value:1.67E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.41|P-value:6.82E-5

Top fitness defect scores for YOR306C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1727 st034309 5.18 9.9 µM 4.44E-9 14 1.09E-7
2 SGTC_549 1661-1316 4.28 519.0 µM 1.02E-6 11 9.19E-6
3 SGTC_1938 st074717 4.17 56.4 µM 1.92E-6 8 1.54E-5
4 SGTC_164 4100-3994 4.11 89.6 µM 2.60E-6 25 1.97E-5
5 SGTC_1096 rimcazole 3.89 32.2 µM 8.16E-6 11 5.03E-5
6 SGTC_634 1611-4317 3.88 11.2 µM 8.53E-6 ERG2 17 5.22E-5
7 SGTC_1736 st036774 3.75 51.0 µM 1.61E-5 41 8.75E-5
8 SGTC_685 1278-0033 3.71 54.9 µM 1.98E-5 60S ribosome export 29 1.04E-4
9 SGTC_1379 2144-0755 3.62 36.5 µM 3.09E-5 32 1.50E-4
10 SGTC_2298 7976326 3.44 193.8 µM 7.07E-5 19 2.95E-4
11 SGTC_1215 3852-0577 3.41 11.2 µM 7.84E-5 28 3.21E-4
12 SGTC_967 1306-0166 3.30 352.0 µM 1.29E-4 68 4.83E-4
13 SGTC_1854 st056233 3.29 32.9 µM 1.34E-4 amide catabolism 39 4.97E-4
14 SGTC_1971 st069429 3.27 63.5 µM 1.48E-4 60S ribosome export 31 5.41E-4
15 SGTC_2014 4013930 3.26 200.0 µM 1.51E-4 71 5.50E-4
16 SGTC_793 0488-0545 3.26 106.0 µM 1.57E-4 31 5.66E-4
17 SGTC_345 1362-0200 3.25 395.0 µM 1.63E-4 42 5.85E-4
18 SGTC_801 0866-0028 3.14 10.1 µM 2.54E-4 80 8.42E-4
19 SGTC_1285 0929-0069 3.10 65.5 µM 2.98E-4 53 9.62E-4
20 SGTC_517 1365-0151 3.10 113.0 µM 3.03E-4 65 9.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.23E-17 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.122 1.43E-12 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.097 1.87E-8 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.096 2.53E-8 YIL165C_p YIL165C_p hom Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene
0.094 4.87E-8 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.092 8.25E-8 YHL022C SPO11 hom Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
0.091 1.27E-7 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.091 1.21E-7 YPL152W-A_p YPL152W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.086 5.53E-7 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.085 8.25E-7 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.084 1.02E-6 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
0.083 1.29E-6 YKR087C OMA1 hom Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
0.083 1.67E-6 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
0.080 3.68E-6 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.080 3.97E-6 YOL094C RFC4 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon