YOR308C / SNU66

Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR308C / SNU66

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.17|P-value:1.60E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.35|P-value:4.78E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.16|P-value:8.78E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.35|P-value:4.61E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.16|P-value:2.09E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.10|P-value:2.71E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.29|P-value:5.91E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.25|P-value:6.42E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.66|P-value:1.45E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.48|P-value:4.74E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.82|P-value:7.75E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.05|P-value:2.91E-7 ID:SGTC_1886|Compound:st057356|FD-Score:-3.84|P-value:7.82E-5 ID:SGTC_1948|Compound:st076329|FD-Score:-5.61|P-value:1.59E-8 ID:SGTC_2382|Compound:9035899|FD-Score:-3.63|P-value:1.71E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.34|P-value:4.72E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.72|P-value:1.16E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.02|P-value:3.63E-5 ID:SGTC_2889|Compound:9059656|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.09|P-value:2.66E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-3.73|P-value:1.18E-4 ID:SGTC_3135|Compound:9127742|FD-Score:5.91|P-value:2.55E-9 ID:SGTC_3283|Compound:9109332|FD-Score:-3.18|P-value:8.77E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.37|P-value:4.31E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.17|P-value:1.60E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.35|P-value:4.78E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.16|P-value:8.78E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:3.35|P-value:4.61E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.16|P-value:2.09E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.10|P-value:2.71E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.29|P-value:5.91E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.25|P-value:6.42E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.66|P-value:1.45E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.48|P-value:4.74E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.82|P-value:7.75E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.05|P-value:2.91E-7 ID:SGTC_1886|Compound:st057356|FD-Score:-3.84|P-value:7.82E-5 ID:SGTC_1948|Compound:st076329|FD-Score:-5.61|P-value:1.59E-8 ID:SGTC_2382|Compound:9035899|FD-Score:-3.63|P-value:1.71E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.34|P-value:4.72E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.72|P-value:1.16E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.02|P-value:3.63E-5 ID:SGTC_2889|Compound:9059656|FD-Score:3.17|P-value:8.55E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.09|P-value:2.66E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-3.73|P-value:1.18E-4 ID:SGTC_3135|Compound:9127742|FD-Score:5.91|P-value:2.55E-9 ID:SGTC_3283|Compound:9109332|FD-Score:-3.18|P-value:8.77E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.37|P-value:4.31E-4

Top fitness defect scores for YOR308C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3135 9127742 5.91 49.5 µM 2.55E-9 3 1.70E-9
2 SGTC_6 0844-0013 5.17 19.8 µM 1.60E-7 33 1.17E-7
3 SGTC_1875 nocodazole 5.05 6.0 µM 2.91E-7 tubulin folding & SWR complex 37 2.17E-7
4 SGTC_1042 0350-0096 4.48 82.0 µM 4.74E-6 TSC3-RPN4 14 3.77E-6
5 SGTC_3123 9126162 4.09 49.5 µM 2.66E-5 15 2.20E-5
6 SGTC_1090 efavirenz 3.82 20.7 µM 7.75E-5 26 6.58E-5
7 SGTC_2762 leflunomide 3.72 42.1 µM 1.16E-4 41 9.93E-5
8 SGTC_909 3448-9333 3.66 149.0 µM 1.45E-4 25 1.24E-4
9 SGTC_965 1291-5240 3.48 308.0 µM 2.91E-4 47 2.55E-4
10 SGTC_1367 1812-0510 3.41 76.9 µM 3.63E-4 43 3.19E-4
11 SGTC_3353 9151644 3.37 39.3 µM 4.31E-4 31 3.80E-4
12 SGTC_286 k060-0067 3.35 22.9 µM 4.61E-4 tubulin folding & SWR complex 36 4.07E-4
13 SGTC_2755 lomerizine 3.34 42.7 µM 4.72E-4 46 4.17E-4
14 SGTC_760 0568-0725 3.25 82.9 µM 6.42E-4 28 5.71E-4
15 SGTC_2889 9059656 3.17 52.0 µM 8.55E-4 27 7.65E-4
16 SGTC_1777 st045864 3.16 34.8 µM 8.72E-4 29 7.80E-4
17 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.16 300.0 µM 8.78E-4 heat shock/prefoldin 71 7.86E-4
18 SGTC_758 0868-0029 3.06 16.0 µM 0.00123 29 0.00111
19 SGTC_3108 9121785 2.99 49.5 µM 0.00153 52 0.00138
20 SGTC_693 4161-2696 2.99 114.0 µM 0.00155 30 0.00140

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 1.70E-30 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.143 6.55E-17 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.140 3.24E-16 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.126 2.52E-13 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.124 5.67E-13 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.123 8.59E-13 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.122 1.20E-12 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.115 2.44E-11 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.115 2.45E-11 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.114 4.02E-11 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.113 4.89E-11 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.111 1.14E-10 YDR198C RKM2 hom Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp
0.109 2.18E-10 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.107 5.92E-10 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.106 6.19E-10 YJL108C PRM10 hom Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation