YOR314W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR314W / YOR314W

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.25|P-value:5.38E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.07|P-value:9.89E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.25|P-value:6.27E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.10|P-value:8.84E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.16|P-value:8.65E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.29|P-value:7.98E-6 ID:SGTC_470|Compound:aa-861|FD-Score:-3.25|P-value:6.30E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.34|P-value:6.32E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.97|P-value:3.96E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:3.43|P-value:2.77E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.15|P-value:7.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:5.58|P-value:1.07E-8 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.14|P-value:9.03E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.64|P-value:1.25E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.11|P-value:1.81E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-4.23|P-value:1.31E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.21|P-value:7.24E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.19|P-value:7.65E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.36|P-value:3.51E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.07|P-value:9.97E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.16|P-value:1.40E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.32|P-value:4.05E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.16|P-value:1.44E-5 ID:SGTC_1763|Compound:st044482|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_1807|Compound:st050092|FD-Score:4.26|P-value:9.05E-6 ID:SGTC_1962|Compound:st076595|FD-Score:3.12|P-value:8.40E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.67|P-value:1.32E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-5.13|P-value:1.69E-7 ID:SGTC_2118|Compound:5526350|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.19|P-value:1.56E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.43|P-value:3.34E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.92|P-value:4.98E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-3.27|P-value:5.76E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.34|P-value:4.62E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.63|P-value:1.56E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.60|P-value:1.46E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.10|P-value:8.90E-4 ID:SGTC_2699|Compound:st077704|FD-Score:5.58|P-value:1.04E-8 ID:SGTC_2705|Compound:st078069|FD-Score:-4.47|P-value:4.42E-6 ID:SGTC_2712|Compound:st079126|FD-Score:-4.45|P-value:4.86E-6 ID:SGTC_2804|Compound:7954240|FD-Score:4.72|P-value:1.02E-6 ID:SGTC_2945|Compound:9067681|FD-Score:3.28|P-value:4.84E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.07|P-value:2.10E-5 ID:SGTC_3022|Compound:9087993|FD-Score:3.25|P-value:5.30E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.16|P-value:8.72E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.25|P-value:5.38E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.07|P-value:9.89E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.25|P-value:6.27E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.10|P-value:8.84E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.16|P-value:8.65E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.29|P-value:7.98E-6 ID:SGTC_470|Compound:aa-861|FD-Score:-3.25|P-value:6.30E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.34|P-value:6.32E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.97|P-value:3.96E-5 ID:SGTC_591|Compound:4299-0174|FD-Score:3.43|P-value:2.77E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.15|P-value:7.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:5.58|P-value:1.07E-8 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.14|P-value:9.03E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.64|P-value:1.25E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.11|P-value:1.81E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-4.23|P-value:1.31E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.21|P-value:7.24E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.19|P-value:7.65E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.36|P-value:3.51E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.07|P-value:9.97E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.16|P-value:1.40E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.32|P-value:4.05E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.16|P-value:1.44E-5 ID:SGTC_1763|Compound:st044482|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_1807|Compound:st050092|FD-Score:4.26|P-value:9.05E-6 ID:SGTC_1962|Compound:st076595|FD-Score:3.12|P-value:8.40E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.67|P-value:1.32E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-5.13|P-value:1.69E-7 ID:SGTC_2118|Compound:5526350|FD-Score:3.31|P-value:4.21E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-4.19|P-value:1.56E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.43|P-value:3.34E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.92|P-value:4.98E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-3.27|P-value:5.76E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.34|P-value:4.62E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-3.63|P-value:1.56E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.60|P-value:1.46E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.10|P-value:8.90E-4 ID:SGTC_2699|Compound:st077704|FD-Score:5.58|P-value:1.04E-8 ID:SGTC_2705|Compound:st078069|FD-Score:-4.47|P-value:4.42E-6 ID:SGTC_2712|Compound:st079126|FD-Score:-4.45|P-value:4.86E-6 ID:SGTC_2804|Compound:7954240|FD-Score:4.72|P-value:1.02E-6 ID:SGTC_2945|Compound:9067681|FD-Score:3.28|P-value:4.84E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.07|P-value:2.10E-5 ID:SGTC_3022|Compound:9087993|FD-Score:3.25|P-value:5.30E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.16|P-value:8.72E-4

Top fitness defect scores for YOR314W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2699 st077704 5.58 54.6 µM 1.04E-8 endomembrane recycling 23 1.20E-8
2 SGTC_931 2812-0076 5.58 566.0 µM 1.07E-8 5 1.23E-8
3 SGTC_2804 7954240 4.72 19.5 µM 1.02E-6 16 1.16E-6
4 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 4.34 150.0 µM 6.32E-6 Golgi 34 7.08E-6
5 SGTC_359 0081-0058 4.29 15.9 µM 7.98E-6 60S ribosome export 32 8.92E-6
6 SGTC_1807 st050092 4.26 58.9 µM 9.05E-6 60S ribosome export 6 1.01E-5
7 SGTC_1384 3089-0840 4.16 101.0 µM 1.40E-5 12 1.57E-5
8 SGTC_1757 st041620 4.16 31.8 µM 1.44E-5 27 1.61E-5
9 SGTC_1090 efavirenz 4.11 20.7 µM 1.81E-5 18 2.02E-5
10 SGTC_2971 9092186 4.07 9.9 µM 2.10E-5 ergosterol biosynthesis 28 2.34E-5
11 SGTC_1763 st044482 3.66 94.5 µM 1.16E-4 copper-dependent oxidative stress 25 1.28E-4
12 SGTC_993 3909-8757 3.64 62.7 µM 1.25E-4 32 1.37E-4
13 SGTC_2580 diallyl disulphide 3.60 81.4 µM 1.46E-4 28 1.60E-4
14 SGTC_2966 9084041 3.50 48.0 µM 2.14E-4 49 2.35E-4
15 SGTC_591 4299-0174 3.43 154.0 µM 2.77E-4 17 3.04E-4
16 SGTC_1196 1588-0294 3.36 184.0 µM 3.51E-4 28 3.84E-4
17 SGTC_1741 st038134 3.32 10.2 µM 4.05E-4 55 4.42E-4
18 SGTC_2118 5526350 3.31 200.0 µM 4.21E-4 32 4.60E-4
19 SGTC_2945 9067681 3.28 61.8 µM 4.84E-4 31 5.28E-4
20 SGTC_3022 9087993 3.25 49.5 µM 5.30E-4 20 5.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.70E-17 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.105 1.14E-9 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.093 6.62E-8 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
0.092 8.32E-8 YEL052W AFG1 hom Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
0.089 2.31E-7 YJL115W ASF1 hom Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
0.085 7.26E-7 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.084 9.94E-7 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.080 3.24E-6 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.080 3.60E-6 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.080 3.58E-6 YAL022C FUN26 hom Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
0.077 9.01E-6 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.074 1.89E-5 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.072 2.71E-5 YHL015W-A_p YHL015W-A_p hom Putative protein of unknown function
0.072 3.00E-5 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
0.070 4.96E-5 YJL067W_d YJL067W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data