YOR331C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR331C / YOR331C

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-3.25|P-value:7.49E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.73|P-value:1.43E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.39|P-value:3.06E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.79|P-value:1.15E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.71|P-value:8.33E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:3.66|P-value:4.50E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.75|P-value:3.29E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.62|P-value:5.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.04|P-value:4.44E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:4.26|P-value:5.06E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.46|P-value:8.58E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.56|P-value:1.65E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.63|P-value:5.01E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.49|P-value:7.97E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.33|P-value:5.80E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.65|P-value:1.93E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.40|P-value:4.51E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.21|P-value:8.34E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.90|P-value:1.98E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.63|P-value:5.03E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:5.49|P-value:2.36E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:4.47|P-value:2.19E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:4.51|P-value:1.88E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:-4.47|P-value:7.63E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.75|P-value:1.33E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.85|P-value:9.30E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-5.31|P-value:1.54E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.73|P-value:3.49E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.45|P-value:8.86E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.44|P-value:9.12E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.96|P-value:1.58E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.07|P-value:1.05E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.85|P-value:2.34E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.69|P-value:4.01E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.09|P-value:3.70E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.50|P-value:7.61E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.94|P-value:1.72E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.76|P-value:2.16E-6 ID:SGTC_2290|Compound:7904846|FD-Score:4.83|P-value:4.82E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-5.53|P-value:5.22E-8 ID:SGTC_2309|Compound:7664088|FD-Score:-6.57|P-value:1.52E-10 ID:SGTC_2311|Compound:7694451|FD-Score:-3.56|P-value:2.59E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.19|P-value:8.92E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.97|P-value:1.50E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.55|P-value:6.37E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.82|P-value:1.03E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.94|P-value:6.59E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.43|P-value:9.46E-4 ID:SGTC_2867|Compound:9039098|FD-Score:5.20|P-value:9.17E-7 ID:SGTC_2869|Compound:9037858|FD-Score:4.57|P-value:1.45E-5 ID:SGTC_3012|Compound:9080433|FD-Score:4.53|P-value:1.72E-5 ID:SGTC_3129|Compound:9127257|FD-Score:4.16|P-value:7.42E-5 ID:SGTC_3197|Compound:9113331|FD-Score:4.03|P-value:1.20E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.32|P-value:5.83E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.76|P-value:3.17E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:-3.25|P-value:7.49E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.73|P-value:1.43E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.39|P-value:3.06E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.79|P-value:1.15E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.71|P-value:8.33E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:3.66|P-value:4.50E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.75|P-value:3.29E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.62|P-value:5.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.04|P-value:4.44E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:4.26|P-value:5.06E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.46|P-value:8.58E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.56|P-value:1.65E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.63|P-value:5.01E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.49|P-value:7.97E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.33|P-value:5.80E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.65|P-value:1.93E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.40|P-value:4.51E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.21|P-value:8.34E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.90|P-value:1.98E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.63|P-value:5.03E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:5.49|P-value:2.36E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:4.47|P-value:2.19E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:4.51|P-value:1.88E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:-4.47|P-value:7.63E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.75|P-value:1.33E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.85|P-value:9.30E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-5.31|P-value:1.54E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.73|P-value:3.49E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.45|P-value:8.86E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.44|P-value:9.12E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.96|P-value:1.58E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.07|P-value:1.05E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.85|P-value:2.34E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.69|P-value:4.01E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.09|P-value:3.70E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.50|P-value:7.61E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.94|P-value:1.72E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-4.76|P-value:2.16E-6 ID:SGTC_2290|Compound:7904846|FD-Score:4.83|P-value:4.82E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.83|P-value:2.48E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-5.53|P-value:5.22E-8 ID:SGTC_2309|Compound:7664088|FD-Score:-6.57|P-value:1.52E-10 ID:SGTC_2311|Compound:7694451|FD-Score:-3.56|P-value:2.59E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.19|P-value:8.92E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.97|P-value:1.50E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.55|P-value:6.37E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.82|P-value:1.03E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.94|P-value:6.59E-5 ID:SGTC_2862|Compound:9027634|FD-Score:3.43|P-value:9.46E-4 ID:SGTC_2867|Compound:9039098|FD-Score:5.20|P-value:9.17E-7 ID:SGTC_2869|Compound:9037858|FD-Score:4.57|P-value:1.45E-5 ID:SGTC_3012|Compound:9080433|FD-Score:4.53|P-value:1.72E-5 ID:SGTC_3129|Compound:9127257|FD-Score:4.16|P-value:7.42E-5 ID:SGTC_3197|Compound:9113331|FD-Score:4.03|P-value:1.20E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.32|P-value:5.83E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.76|P-value:3.17E-4

Top fitness defect scores for YOR331C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_432 NS 1619 5.56 61.3 µM 1.65E-7 5 1.36E-8
2 SGTC_827 3253-0474 5.49 693.0 µM 2.36E-7 3 2.06E-8
3 SGTC_2867 9039098 5.20 71.4 µM 9.17E-7 iron homeostasis 9 9.84E-8
4 SGTC_2290 7904846 4.83 200.0 µM 4.82E-6 9 6.67E-7
5 SGTC_102 gallobenzophenone 4.71 83.6 µM 8.33E-6 redox potentiating 29 1.26E-6
6 SGTC_2869 9037858 4.57 32.5 µM 1.45E-5 7 2.39E-6
7 SGTC_3012 9080433 4.53 71.4 µM 1.72E-5 4 2.89E-6
8 SGTC_985 1493-0307 4.51 8.7 µM 1.88E-5 TSC3-RPN4 16 3.22E-6
9 SGTC_830 4076-0286 4.47 57.8 µM 2.19E-5 translation 42 3.84E-6
10 SGTC_79 0052-0007 4.39 94.1 µM 3.06E-5 30 5.63E-6
11 SGTC_316 k060-0003 4.26 58.6 µM 5.06E-5 12 1.01E-5
12 SGTC_3129 9127257 4.16 49.5 µM 7.42E-5 18 1.57E-5
13 SGTC_1601 4'-hydroxyflavanone 4.07 55.5 µM 1.05E-4 RPP1 & pyrimidine depletion 27 2.35E-5
14 SGTC_3197 9113331 4.03 49.5 µM 1.20E-4 30 2.74E-5
15 SGTC_2416 tofa 3.97 880.0 nM 1.50E-4 sphingolipid biosynthesis & PDR1 50 3.53E-5
16 SGTC_1600 coumarin 106 3.96 71.1 µM 1.58E-4 27 3.77E-5
17 SGTC_2276 7947513 3.94 42.1 µM 1.72E-4 22 4.15E-5
18 SGTC_691 1548-0686 3.90 185.0 µM 1.98E-4 36 4.89E-5
19 SGTC_1623 st003709 3.85 20.3 µM 2.34E-4 calcium & mitochondrial duress 78 5.93E-5
20 SGTC_2291 7917025 3.83 104.3 µM 2.48E-4 iron homeostasis 54 6.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.47E-23 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.163 1.65E-21 YDL185W VMA1 hom Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
0.154 3.26E-19 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.136 2.18E-15 YPR036W VMA13 hom Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
0.131 2.34E-14 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.37E-12 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.108 2.99E-10 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.105 1.15E-9 YHR026W VMA16 hom Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
0.098 1.33E-8 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.098 1.46E-8 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.096 2.55E-8 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.096 2.90E-8 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.092 1.04E-7 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.089 2.20E-7 YDL006W PTC1 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
0.089 2.40E-7 YLR148W PEP3 hom Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis