YOR338W_p

Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR338W / YOR338W

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:2.85|P-value:9.36E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.54|P-value:5.69E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-5.24|P-value:6.27E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:3.37|P-value:1.17E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.28|P-value:1.74E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.32|P-value:1.45E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.49|P-value:7.17E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.06|P-value:4.44E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.04|P-value:4.51E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.23|P-value:2.15E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.89|P-value:8.18E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:2.84|P-value:9.57E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:2.93|P-value:7.04E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.34|P-value:1.35E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.77|P-value:2.09E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.05|P-value:4.61E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.35|P-value:1.29E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.47|P-value:7.85E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.38|P-value:1.15E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.91|P-value:7.50E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.12|P-value:3.27E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_1757|Compound:st041620|FD-Score:2.89|P-value:8.07E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:2.93|P-value:6.91E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.42|P-value:1.04E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-4.08|P-value:4.61E-6 ID:SGTC_1992|Compound:st073643|FD-Score:3.39|P-value:1.09E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-2.90|P-value:8.18E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.28|P-value:1.87E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.16|P-value:3.07E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.25|P-value:1.96E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.39|P-value:8.78E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.41|P-value:9.80E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.16|P-value:2.87E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-2.87|P-value:9.36E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.00|P-value:5.35E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.32|P-value:1.59E-4 ID:SGTC_2982|Compound:9019404|FD-Score:2.89|P-value:8.03E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.91|P-value:7.43E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.32|P-value:1.47E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.64|P-value:3.61E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-4.33|P-value:1.26E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.95|P-value:9.11E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:2.85|P-value:9.36E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.54|P-value:5.69E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:-5.24|P-value:6.27E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:3.37|P-value:1.17E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.28|P-value:1.74E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.32|P-value:1.45E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.49|P-value:7.17E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.06|P-value:4.44E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.04|P-value:4.51E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.23|P-value:2.15E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.89|P-value:8.18E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:2.84|P-value:9.57E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:2.93|P-value:7.04E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.33|P-value:1.43E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.34|P-value:1.35E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.77|P-value:2.09E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.05|P-value:4.61E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.35|P-value:1.29E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.47|P-value:7.85E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.38|P-value:1.15E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.91|P-value:7.50E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.12|P-value:3.27E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_1757|Compound:st041620|FD-Score:2.89|P-value:8.07E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:2.93|P-value:6.91E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.42|P-value:1.04E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-4.08|P-value:4.61E-6 ID:SGTC_1992|Compound:st073643|FD-Score:3.39|P-value:1.09E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-2.90|P-value:8.18E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.28|P-value:1.87E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.16|P-value:3.07E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.25|P-value:1.96E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.39|P-value:8.78E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.41|P-value:9.80E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.16|P-value:2.87E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-2.87|P-value:9.36E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.00|P-value:5.35E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.32|P-value:1.59E-4 ID:SGTC_2982|Compound:9019404|FD-Score:2.89|P-value:8.03E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.91|P-value:7.43E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.32|P-value:1.47E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.64|P-value:3.61E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-4.33|P-value:1.26E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.95|P-value:9.11E-6

Top fitness defect scores for YOR338W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2500 5-alpha-androstan-3,17-dione 4.39 61.4 µM 8.78E-7 31 5.80E-6
2 SGTC_3052 9092717 3.64 49.5 µM 3.61E-5 42 1.36E-4
3 SGTC_164 4100-3994 3.54 89.6 µM 5.69E-5 45 2.01E-4
4 SGTC_450 aminopyrene 3.49 156.0 nM 7.17E-5 53 2.45E-4
5 SGTC_1589 2',5'-dimethoxyflavone 3.47 47.2 µM 7.85E-5 36 2.64E-4
6 SGTC_2605 digitonin 3.41 300.0 nM 9.80E-5 49 3.19E-4
7 SGTC_1992 st073643 3.39 23.3 µM 1.09E-4 mitochondrial processes 21 3.50E-4
8 SGTC_1592 4',5'-dihydroxyflavone 3.38 8.8 µM 1.15E-4 60S ribosome export 31 3.66E-4
9 SGTC_367 0335-0881 3.37 7.1 µM 1.17E-4 ubiquinone biosynthesis & proteasome 113 3.72E-4
10 SGTC_1567 st069303 3.35 68.4 µM 1.29E-4 mitochondrial processes 40 4.03E-4
11 SGTC_1419 3993-2473 3.34 62.6 µM 1.35E-4 38 4.20E-4
12 SGTC_1397 3532-0190 3.33 20.1 µM 1.43E-4 16 4.41E-4
13 SGTC_432 NS 1619 3.32 61.3 µM 1.45E-4 52 4.44E-4
14 SGTC_3017 9080681 3.32 49.5 µM 1.47E-4 28 4.52E-4
15 SGTC_421 streptovitacin 3.28 30.0 mM 1.74E-4 56 5.21E-4
16 SGTC_2331 7980721 3.25 200.0 µM 1.96E-4 56 5.75E-4
17 SGTC_1128 3448-9350 3.23 235.0 µM 2.15E-4 50 6.24E-4
18 SGTC_2033 5192550 3.22 145.0 µM 2.19E-4 35 6.33E-4
19 SGTC_1748 st037455 3.22 53.6 µM 2.19E-4 66 6.33E-4
20 SGTC_2825 7998094 3.16 58.4 µM 2.87E-4 fatty acid desaturase (OLE1) 59 7.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.56E-15 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.102 3.51E-9 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.48E-7 YLR364W GRX8 hom Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic
0.084 1.10E-6 YBL072C RPS8A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication
0.084 1.20E-6 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.083 1.35E-6 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.083 1.61E-6 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.081 2.72E-6 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.080 3.48E-6 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.080 3.60E-6 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.080 3.90E-6 YNL279W PRM1 hom Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
0.080 3.92E-6 YIL071C PCI8 hom Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
0.077 8.54E-6 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.075 1.20E-5 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.072 3.13E-5 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching