YOR339C / UBC11

Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR339C / UBC11

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:-3.62|P-value:1.03E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.01|P-value:9.26E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.82|P-value:4.50E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.15|P-value:5.70E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.97|P-value:2.09E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.65|P-value:8.02E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.25|P-value:3.92E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.20|P-value:4.70E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.32|P-value:3.41E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.75|P-value:5.46E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.87|P-value:3.17E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.81|P-value:4.11E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.24|P-value:4.56E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.94|P-value:2.32E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-4.80|P-value:4.24E-7 ID:SGTC_1830|Compound:st055982|FD-Score:3.77|P-value:4.92E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.20|P-value:4.76E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.08|P-value:7.33E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.42|P-value:2.04E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.31|P-value:3.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.25|P-value:5.84E-6 ID:SGTC_2395|Compound:5646831|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-4.14|P-value:1.11E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-4.92|P-value:2.20E-7 ID:SGTC_2484|Compound:5809818|FD-Score:-3.69|P-value:7.76E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.78|P-value:4.81E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.63|P-value:8.91E-7 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.20|P-value:5.30E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.20|P-value:4.67E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.92|P-value:5.18E-10 ID:SGTC_2696|Compound:st077691|FD-Score:5.02|P-value:1.11E-7 ID:SGTC_2799|Compound:7812892|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.43|P-value:1.99E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.20|P-value:4.79E-4 ID:SGTC_2995|Compound:9067767|FD-Score:6.56|P-value:6.73E-12 ID:SGTC_3262|Compound:9137218|FD-Score:3.41|P-value:2.12E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-3.51|P-value:1.62E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.16|P-value:5.37E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.99|P-value:2.15E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.89|P-value:3.28E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.62|P-value:1.03E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.01|P-value:9.26E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.82|P-value:4.50E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.15|P-value:5.70E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.97|P-value:2.09E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.65|P-value:8.02E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.25|P-value:3.92E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.20|P-value:4.70E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.32|P-value:3.41E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.75|P-value:5.46E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.87|P-value:3.17E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.81|P-value:4.11E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.24|P-value:4.56E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.94|P-value:2.32E-5 ID:SGTC_1725|Compound:st036284|FD-Score:-4.80|P-value:4.24E-7 ID:SGTC_1830|Compound:st055982|FD-Score:3.77|P-value:4.92E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.20|P-value:4.76E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.08|P-value:7.33E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.49|P-value:1.58E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.42|P-value:2.04E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-3.31|P-value:3.42E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.25|P-value:5.84E-6 ID:SGTC_2395|Compound:5646831|FD-Score:3.30|P-value:3.23E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-4.14|P-value:1.11E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-4.92|P-value:2.20E-7 ID:SGTC_2484|Compound:5809818|FD-Score:-3.69|P-value:7.76E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.78|P-value:4.81E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.63|P-value:8.91E-7 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.20|P-value:5.30E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.20|P-value:4.67E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.92|P-value:5.18E-10 ID:SGTC_2696|Compound:st077691|FD-Score:5.02|P-value:1.11E-7 ID:SGTC_2799|Compound:7812892|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.43|P-value:1.99E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.20|P-value:4.79E-4 ID:SGTC_2995|Compound:9067767|FD-Score:6.56|P-value:6.73E-12 ID:SGTC_3262|Compound:9137218|FD-Score:3.41|P-value:2.12E-4 ID:SGTC_3267|Compound:9137951|FD-Score:-3.51|P-value:1.62E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.16|P-value:5.37E-4 ID:SGTC_3273|Compound:9137859|FD-Score:-3.99|P-value:2.15E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.89|P-value:3.28E-5

Top fitness defect scores for YOR339C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2995 9067767 6.56 71.4 µM 6.73E-12 2 2.70E-11
2 SGTC_2626 ethyl orsellinate 5.92 100.0 µM 5.18E-10 5 1.63E-9
3 SGTC_2696 st077691 5.02 74.3 µM 1.11E-7 12 2.58E-7
4 SGTC_2564 betulinic acid 4.63 100.0 µM 8.91E-7 20 1.84E-6
5 SGTC_2327 6189656 4.25 200.0 µM 5.84E-6 17 1.09E-5
6 SGTC_278 4092-0821 3.97 23.9 µM 2.09E-5 plasma membrane duress 40 3.63E-5
7 SGTC_1673 st016611 3.94 27.3 µM 2.32E-5 45 4.00E-5
8 SGTC_1237 0330-0133 3.87 46.1 µM 3.17E-5 ergosterol biosynthesis 27 5.36E-5
9 SGTC_1261 0712-0010 3.81 12.7 µM 4.11E-5 RNA processing & uracil transport 26 6.86E-5
10 SGTC_2487 5918373 3.78 44.0 µM 4.81E-5 20 7.97E-5
11 SGTC_1830 st055982 3.77 50.3 µM 4.92E-5 24 8.13E-5
12 SGTC_1001 4048-4355 3.75 44.4 µM 5.46E-5 copper-dependent oxidative stress 41 8.96E-5
13 SGTC_410 α-linolenic acid 3.65 100.0 µM 8.02E-5 excess fatty acid 45 1.29E-4
14 SGTC_2045 5106652 3.49 78.0 µM 1.58E-4 23 2.45E-4
15 SGTC_2823 7987624 3.43 58.4 µM 1.99E-4 53 3.04E-4
16 SGTC_2105 5350118 3.42 200.0 µM 2.04E-4 45 3.12E-4
17 SGTC_2447 5741742 3.41 33.8 µM 2.11E-4 42 3.22E-4
18 SGTC_3262 9137218 3.41 49.5 µM 2.12E-4 8 3.23E-4
19 SGTC_2395 5646831 3.30 180.2 µM 3.23E-4 50 4.81E-4
20 SGTC_611 3453-1652 3.25 23.7 µM 3.92E-4 48 5.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.35E-10 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.091 1.12E-7 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.090 1.80E-7 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.089 2.32E-7 YJL133W MRS3 hom Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication
0.088 3.17E-7 YIL139C REV7 hom Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.087 4.31E-7 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.087 5.07E-7 YKL018W SWD2 het Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
0.086 5.93E-7 YNL329C PEX6 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
0.084 1.19E-6 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.082 2.04E-6 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.078 5.99E-6 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.077 8.34E-6 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.076 9.41E-6 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.075 1.47E-5 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.073 2.41E-5 YOL155C HPF1 hom Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines