YOR343C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR343C / YOR343C

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.04|P-value:4.06E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.38|P-value:6.66E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:4.53|P-value:2.82E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.10|P-value:2.89E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.83|P-value:1.11E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.53|P-value:4.98E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.30|P-value:1.25E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.68|P-value:2.26E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:2.85|P-value:8.25E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.20|P-value:2.04E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:2.86|P-value:8.01E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.66|P-value:2.67E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.19|P-value:2.15E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.79|P-value:1.44E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.77|P-value:1.62E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:8.80|P-value:1.14E-22 ID:SGTC_950|Compound:1165-0508|FD-Score:-2.81|P-value:9.04E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.16|P-value:2.34E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.09|P-value:3.01E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.93|P-value:5.76E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.96|P-value:6.34E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.64|P-value:2.75E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.98|P-value:4.97E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:2.87|P-value:7.86E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.19|P-value:4.92E-9 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.69|P-value:2.38E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.03|P-value:4.18E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.92|P-value:6.48E-4 ID:SGTC_1777|Compound:st045864|FD-Score:2.90|P-value:6.85E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.21|P-value:1.70E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.11|P-value:2.79E-4 ID:SGTC_1935|Compound:st074532|FD-Score:2.99|P-value:4.85E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-2.80|P-value:9.51E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.26|P-value:1.30E-6 ID:SGTC_2165|Compound:5727197|FD-Score:-3.77|P-value:1.44E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.81|P-value:9.63E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.07|P-value:3.49E-6 ID:SGTC_2370|Compound:9071495|FD-Score:2.92|P-value:6.32E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.22|P-value:1.56E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.94|P-value:6.74E-6 ID:SGTC_2378|Compound:9074213|FD-Score:3.14|P-value:2.67E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.91|P-value:6.61E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-2.82|P-value:8.80E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.56|P-value:3.98E-5 ID:SGTC_2402|Compound:5553605|FD-Score:5.91|P-value:3.31E-11 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.27|P-value:1.53E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.91|P-value:2.88E-8 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.96|P-value:5.08E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.66|P-value:2.70E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.09|P-value:3.31E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-2.91|P-value:6.35E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.45|P-value:6.61E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.97|P-value:5.51E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.27|P-value:1.22E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.89|P-value:7.16E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.08|P-value:3.24E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.12|P-value:2.94E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.37|P-value:1.14E-20 ID:SGTC_3166|Compound:9102297|FD-Score:-3.12|P-value:2.72E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.05|P-value:3.96E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.57|P-value:2.21E-7 ID:SGTC_3273|Compound:9137859|FD-Score:-3.09|P-value:3.06E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.73|P-value:1.78E-5 ID:SGTC_3293|Compound:9120939|FD-Score:4.06|P-value:3.68E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.12|P-value:2.65E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.04|P-value:4.06E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.38|P-value:6.66E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:4.53|P-value:2.82E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.10|P-value:2.89E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.83|P-value:1.11E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.53|P-value:4.98E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.30|P-value:1.25E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.68|P-value:2.26E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:2.85|P-value:8.25E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.20|P-value:2.04E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:2.86|P-value:8.01E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.66|P-value:2.67E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.19|P-value:2.15E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.79|P-value:1.44E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.77|P-value:1.62E-5 ID:SGTC_945|Compound:3381-0768|FD-Score:8.80|P-value:1.14E-22 ID:SGTC_950|Compound:1165-0508|FD-Score:-2.81|P-value:9.04E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.16|P-value:2.34E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.09|P-value:3.01E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.93|P-value:5.76E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.96|P-value:6.34E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.64|P-value:2.75E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.98|P-value:4.97E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:2.87|P-value:7.86E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:5.19|P-value:4.92E-9 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.69|P-value:2.38E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.03|P-value:4.18E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.92|P-value:6.48E-4 ID:SGTC_1777|Compound:st045864|FD-Score:2.90|P-value:6.85E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.36|P-value:1.05E-4 ID:SGTC_1886|Compound:st057356|FD-Score:4.21|P-value:1.70E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.11|P-value:2.79E-4 ID:SGTC_1935|Compound:st074532|FD-Score:2.99|P-value:4.85E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-2.80|P-value:9.51E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.26|P-value:1.30E-6 ID:SGTC_2165|Compound:5727197|FD-Score:-3.77|P-value:1.44E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.81|P-value:9.63E-4 ID:SGTC_2342|Compound:7990637|FD-Score:4.07|P-value:3.49E-6 ID:SGTC_2370|Compound:9071495|FD-Score:2.92|P-value:6.32E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.22|P-value:1.56E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.94|P-value:6.74E-6 ID:SGTC_2378|Compound:9074213|FD-Score:3.14|P-value:2.67E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.91|P-value:6.61E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-2.82|P-value:8.80E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.56|P-value:3.98E-5 ID:SGTC_2402|Compound:5553605|FD-Score:5.91|P-value:3.31E-11 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.27|P-value:1.53E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.91|P-value:2.88E-8 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.96|P-value:5.08E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.66|P-value:2.70E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.09|P-value:3.31E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-2.91|P-value:6.35E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.45|P-value:6.61E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.97|P-value:5.51E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.27|P-value:1.22E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.89|P-value:7.16E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-3.08|P-value:3.24E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.12|P-value:2.94E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.37|P-value:1.14E-20 ID:SGTC_3166|Compound:9102297|FD-Score:-3.12|P-value:2.72E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.05|P-value:3.96E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.57|P-value:2.21E-7 ID:SGTC_3273|Compound:9137859|FD-Score:-3.09|P-value:3.06E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.73|P-value:1.78E-5 ID:SGTC_3293|Compound:9120939|FD-Score:4.06|P-value:3.68E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.12|P-value:2.65E-4

Top fitness defect scores for YOR343C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_945 3381-0768 8.80 11.3 µM 1.14E-22 endomembrane recycling 2 6.59E-19
2 SGTC_3059 1327-0034 8.37 3.0 µM 1.14E-20 18 2.88E-17
3 SGTC_2402 5553605 5.91 200.0 µM 3.31E-11 5 1.70E-9
4 SGTC_1568 digitonin 5.19 820.0 nM 4.92E-9 sphingolipid biosynthesis & PDR1 15 1.04E-7
5 SGTC_2522 biochanin a 4.91 4.9 µM 2.88E-8 RNA pol III & RNase P/MRP 3 4.46E-7
6 SGTC_3205 9113483 4.57 49.5 µM 2.21E-7 11 2.39E-6
7 SGTC_133 0724-0033 4.53 378.9 µM 2.82E-7 15 2.93E-6
8 SGTC_127 0180-0333 4.38 59.1 µM 6.66E-7 mitochondrial response to ROS 27 5.95E-6
9 SGTC_2588 indole-3-carbinol 4.27 100.0 µM 1.22E-6 36 9.80E-6
10 SGTC_2038 4100038 4.26 31.0 µM 1.30E-6 plasma membrane duress 39 1.03E-5
11 SGTC_2375 9072683 4.22 200.0 µM 1.56E-6 mitochondrial processes 14 1.20E-5
12 SGTC_1886 st057356 4.21 49.9 µM 1.70E-6 60S ribosome export 13 1.29E-5
13 SGTC_2342 7990637 4.07 118.9 µM 3.49E-6 RNA processing & uracil transport 31 2.34E-5
14 SGTC_3293 9120939 4.06 62.0 µM 3.68E-6 19 2.44E-5
15 SGTC_3195 9113082 4.05 49.5 µM 3.96E-6 16 2.59E-5
16 SGTC_1157 4092-0394 3.96 27.6 µM 6.34E-6 31 3.83E-5
17 SGTC_2377 9073351 3.94 62.6 µM 6.74E-6 ergosterol biosynthesis 25 4.02E-5
18 SGTC_792 4534-1957 3.79 155.0 µM 1.44E-5 37 7.55E-5
19 SGTC_917 harmaline 3.77 728.1 nM 1.62E-5 ergosterol biosynthesis 30 8.32E-5
20 SGTC_1576 erythromycin ethylsuccinate 3.69 23.2 µM 2.38E-5 26 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.11E-11 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.112 7.47E-11 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.109 2.36E-10 YOR316C-A_p YOR316C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.107 4.75E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.103 2.30E-9 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.097 1.85E-8 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.094 4.97E-8 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.093 7.95E-8 YMR189W GCV2 hom P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
0.092 8.89E-8 YPL154C PEP4 hom Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
0.092 9.71E-8 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.091 1.43E-7 YLR255C_d YLR255C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.65E-7 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.088 3.03E-7 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.087 4.49E-7 YDL125C HNT1 hom Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress
0.086 6.00E-7 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0