YOR346W / REV1

Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR346W / REV1

Click on Significant Values for Screen Details ID:SGTC_126|Compound:0417-1624|FD-Score:-3.94|P-value:1.90E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:2.92|P-value:9.02E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.20|P-value:5.56E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.52|P-value:1.18E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.31|P-value:2.00E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-6.30|P-value:1.91E-11 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.59|P-value:7.56E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.60|P-value:8.39E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.11|P-value:5.95E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.13|P-value:5.56E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.08|P-value:6.67E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:4.96|P-value:6.43E-8 ID:SGTC_641|Compound:4092-0595|FD-Score:2.95|P-value:7.98E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.62|P-value:5.48E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.15|P-value:5.14E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-4.15|P-value:7.16E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:5.07|P-value:3.39E-8 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.12|P-value:5.64E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.00|P-value:6.64E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.09|P-value:4.77E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.39|P-value:1.49E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.08|P-value:6.48E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.81|P-value:3.46E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.33|P-value:1.86E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.26|P-value:2.49E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.64|P-value:7.04E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.25|P-value:2.92E-6 ID:SGTC_2269|Compound:7935389|FD-Score:-3.43|P-value:1.73E-4 ID:SGTC_2279|Compound:7948423|FD-Score:5.36|P-value:6.07E-9 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.86|P-value:1.94E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.87|P-value:1.08E-7 ID:SGTC_2570|Compound:licareol|FD-Score:-3.18|P-value:4.48E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:1.69E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.55|P-value:7.55E-5 ID:SGTC_2835|Compound:9006588|FD-Score:4.13|P-value:5.20E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-4.05|P-value:1.12E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-2.97|P-value:9.88E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-5.83|P-value:4.72E-10 ID:SGTC_2861|Compound:9024595|FD-Score:-4.65|P-value:5.45E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.58|P-value:6.70E-5 ID:SGTC_3034|Compound:9090421|FD-Score:-3.01|P-value:8.42E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.94|P-value:1.90E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:2.92|P-value:9.02E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.20|P-value:5.56E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.52|P-value:1.18E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.31|P-value:2.00E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-6.30|P-value:1.91E-11 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.59|P-value:7.56E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.60|P-value:8.39E-5 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.11|P-value:5.95E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.13|P-value:5.56E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.08|P-value:6.67E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:4.96|P-value:6.43E-8 ID:SGTC_641|Compound:4092-0595|FD-Score:2.95|P-value:7.98E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.62|P-value:5.48E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.15|P-value:5.14E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-4.15|P-value:7.16E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:5.07|P-value:3.39E-8 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.12|P-value:5.64E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.00|P-value:6.64E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.09|P-value:4.77E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.39|P-value:1.49E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.08|P-value:6.48E-4 ID:SGTC_1736|Compound:st036774|FD-Score:-3.81|P-value:3.46E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.33|P-value:1.86E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.26|P-value:2.49E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.64|P-value:7.04E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.25|P-value:2.92E-6 ID:SGTC_2269|Compound:7935389|FD-Score:-3.43|P-value:1.73E-4 ID:SGTC_2279|Compound:7948423|FD-Score:5.36|P-value:6.07E-9 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.86|P-value:1.94E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.87|P-value:1.08E-7 ID:SGTC_2570|Compound:licareol|FD-Score:-3.18|P-value:4.48E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:1.69E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.55|P-value:7.55E-5 ID:SGTC_2835|Compound:9006588|FD-Score:4.13|P-value:5.20E-6 ID:SGTC_2841|Compound:9004761|FD-Score:-4.05|P-value:1.12E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-2.97|P-value:9.88E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-5.83|P-value:4.72E-10 ID:SGTC_2861|Compound:9024595|FD-Score:-4.65|P-value:5.45E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.58|P-value:6.70E-5 ID:SGTC_3034|Compound:9090421|FD-Score:-3.01|P-value:8.42E-4

Top fitness defect scores for YOR346W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2279 7948423 5.36 32.9 µM 6.07E-9 5 4.27E-8
2 SGTC_1070 indatraline 5.07 8.8 µM 3.39E-8 60S ribosome export 11 1.98E-7
3 SGTC_634 1611-4317 4.96 11.2 µM 6.43E-8 ERG2 8 3.51E-7
4 SGTC_2569 tetrandrine 4.87 100.0 µM 1.08E-7 8 5.60E-7
5 SGTC_1975 st070967 4.25 30.8 µM 2.92E-6 26 1.06E-5
6 SGTC_2835 9006588 4.13 71.4 µM 5.20E-6 34 1.78E-5
7 SGTC_2520 obtusaquinone 3.86 4.7 µM 1.94E-5 21 5.75E-5
8 SGTC_912 3474-0017 3.62 2.2 µM 5.48E-5 32 1.45E-4
9 SGTC_2871 9038510 3.58 13.0 µM 6.70E-5 30 1.74E-4
10 SGTC_2830 7992007 3.55 71.4 µM 7.55E-5 33 1.94E-4
11 SGTC_1513 0337-0559 3.39 19.0 µM 1.49E-4 29 3.55E-4
12 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.35 70.0 µM 1.69E-4 redox potentiating 99 3.97E-4
13 SGTC_1747 st037496 3.33 66.6 µM 1.86E-4 37 4.33E-4
14 SGTC_426 0988-0037 3.31 14.6 µM 2.00E-4 ERAD & cell cycle 64 4.62E-4
15 SGTC_1752 st044819 3.26 83.0 µM 2.49E-4 46 5.62E-4
16 SGTC_1028 k015-0029 3.17 4.8 µM 3.49E-4 54 7.60E-4
17 SGTC_1277 0873-0036 3.09 22.0 µM 4.77E-4 PDR1 65 0.00100
18 SGTC_1227 3909-8010 3.00 46.6 µM 6.64E-4 62 0.00135
19 SGTC_641 4092-0595 2.95 30.0 µM 7.98E-4 51 0.00159
20 SGTC_286 k060-0067 2.92 22.9 µM 9.02E-4 tubulin folding & SWR complex 57 0.00177

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.27E-15 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.131 2.58E-14 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.129 5.70E-14 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.109 2.24E-10 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.109 2.57E-10 YPL277C_p YPL277C_p hom Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
0.109 2.56E-10 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.100 6.82E-9 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.097 2.11E-8 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.090 1.57E-7 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.089 2.68E-7 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.089 2.69E-7 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.083 1.41E-6 YOR232W MGE1 het Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
0.082 1.91E-6 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.082 1.98E-6 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.082 1.98E-6 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p