YOR350C / MNE1

Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR350C / MNE1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.24|P-value:5.30E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.97|P-value:3.19E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.50|P-value:2.35E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.85|P-value:5.89E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:3.92|P-value:4.42E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.13|P-value:8.77E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.67|P-value:6.86E-9 ID:SGTC_827|Compound:3253-0474|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.16|P-value:7.21E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.24|P-value:5.40E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.99|P-value:2.87E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.49|P-value:2.17E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:7.86|P-value:1.70E-15 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.69|P-value:5.79E-9 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.93|P-value:4.00E-7 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.25|P-value:5.81E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.12|P-value:1.44E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.55|P-value:1.74E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.79|P-value:8.04E-7 ID:SGTC_1765|Compound:st044815|FD-Score:5.09|P-value:1.71E-7 ID:SGTC_2002|Compound:4023503|FD-Score:3.76|P-value:8.50E-5 ID:SGTC_2119|Compound:5528445|FD-Score:4.85|P-value:5.87E-7 ID:SGTC_2487|Compound:5918373|FD-Score:3.36|P-value:3.91E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.88|P-value:4.41E-7 ID:SGTC_2816|Compound:7982706|FD-Score:5.13|P-value:1.39E-7 ID:SGTC_2820|Compound:7989630|FD-Score:-3.47|P-value:2.36E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.49|P-value:2.16E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.39|P-value:5.54E-6 ID:SGTC_3009|Compound:9080819|FD-Score:3.88|P-value:5.17E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.65|P-value:1.18E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.12|P-value:1.88E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-4.99|P-value:2.43E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.24|P-value:5.30E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.97|P-value:3.19E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.50|P-value:2.35E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.85|P-value:5.89E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:3.92|P-value:4.42E-5 ID:SGTC_774|Compound:k060-0086|FD-Score:3.13|P-value:8.77E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.67|P-value:6.86E-9 ID:SGTC_827|Compound:3253-0474|FD-Score:3.32|P-value:4.45E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.16|P-value:7.21E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.24|P-value:5.40E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.99|P-value:2.87E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:3.63|P-value:1.40E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.49|P-value:2.17E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:7.86|P-value:1.70E-15 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.69|P-value:5.79E-9 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.93|P-value:4.00E-7 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.25|P-value:5.81E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.12|P-value:1.44E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.55|P-value:1.74E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.79|P-value:8.04E-7 ID:SGTC_1765|Compound:st044815|FD-Score:5.09|P-value:1.71E-7 ID:SGTC_2002|Compound:4023503|FD-Score:3.76|P-value:8.50E-5 ID:SGTC_2119|Compound:5528445|FD-Score:4.85|P-value:5.87E-7 ID:SGTC_2487|Compound:5918373|FD-Score:3.36|P-value:3.91E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.88|P-value:4.41E-7 ID:SGTC_2816|Compound:7982706|FD-Score:5.13|P-value:1.39E-7 ID:SGTC_2820|Compound:7989630|FD-Score:-3.47|P-value:2.36E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.49|P-value:2.16E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.39|P-value:5.54E-6 ID:SGTC_3009|Compound:9080819|FD-Score:3.88|P-value:5.17E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.65|P-value:1.18E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.12|P-value:1.88E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-4.99|P-value:2.43E-7

Top fitness defect scores for YOR350C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_932 2857-0803 7.86 154.0 µM 1.70E-15 1 1.99E-15
2 SGTC_1073 triclabendazole 5.69 3.1 µM 5.79E-9 9 6.17E-9
3 SGTC_787 4152-0075 5.67 138.0 µM 6.86E-9 2 7.29E-9
4 SGTC_2816 7982706 5.13 58.4 µM 1.39E-7 azole & statin 26 1.45E-7
5 SGTC_1369 1866-0067 5.12 208.0 µM 1.44E-7 RPP1 & pyrimidine depletion 18 1.50E-7
6 SGTC_1765 st044815 5.09 90.4 µM 1.71E-7 10 1.78E-7
7 SGTC_1207 2099-0101 4.93 141.0 µM 4.00E-7 5 4.15E-7
8 SGTC_2119 5528445 4.85 120.6 µM 5.87E-7 7 6.08E-7
9 SGTC_386 1509-0011 4.85 3.1 µM 5.89E-7 115 6.10E-7
10 SGTC_1716 st033144 4.79 30.6 µM 8.04E-7 9 8.32E-7
11 SGTC_2952 9073731 4.39 13.8 µM 5.54E-6 tubulin folding & SWR complex 27 5.67E-6
12 SGTC_3206 9114350 4.12 49.5 µM 1.88E-5 15 1.91E-5
13 SGTC_532 1548-0774 3.92 215.0 µM 4.42E-5 21 4.48E-5
14 SGTC_3009 9080819 3.88 71.4 µM 5.17E-5 19 5.23E-5
15 SGTC_2002 4023503 3.76 131.0 µM 8.50E-5 mitochondrial processes 40 8.57E-5
16 SGTC_367 0335-0881 3.67 7.1 µM 1.22E-4 ubiquinone biosynthesis & proteasome 94 1.22E-4
17 SGTC_930 2810-3379 3.63 265.0 µM 1.40E-4 16 1.41E-4
18 SGTC_1635 st007035 3.61 42.4 µM 1.50E-4 236 1.51E-4
19 SGTC_265 mycophenolic acid 3.50 32.9 µM 2.35E-4 RPP1 & pyrimidine depletion 39 2.36E-4
20 SGTC_2487 5918373 3.36 44.0 µM 3.91E-4 38 3.91E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.22E-25 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.176 7.23E-25 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.161 6.20E-21 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.158 3.58E-20 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.149 3.94E-18 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.149 3.99E-18 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.145 3.28E-17 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.143 8.34E-17 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.143 8.84E-17 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.141 2.32E-16 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.139 6.17E-16 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.136 2.15E-15 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.132 1.41E-14 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.130 4.18E-14 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.129 5.54E-14 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit