YOR359W / VTS1

Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR359W / VTS1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.06|P-value:4.91E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.36|P-value:8.17E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.38|P-value:7.54E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.33|P-value:2.27E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:5.17|P-value:5.46E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:4.06|P-value:6.69E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.73|P-value:1.73E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.69|P-value:4.90E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.04|P-value:7.13E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.46|P-value:4.47E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.51|P-value:4.94E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.47|P-value:5.63E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.99|P-value:6.34E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.32|P-value:9.05E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.36|P-value:7.93E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.69|P-value:3.48E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:3.70|P-value:2.54E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.73|P-value:1.72E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-4.02|P-value:5.62E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-6.51|P-value:2.49E-10 ID:SGTC_1790|Compound:st045711|FD-Score:4.86|P-value:2.32E-6 ID:SGTC_1953|Compound:st076800|FD-Score:3.31|P-value:9.45E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.21|P-value:2.66E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.62|P-value:3.36E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.84|P-value:1.51E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.62|P-value:3.38E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.64|P-value:3.13E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.49|P-value:5.27E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:6.00|P-value:7.36E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.68|P-value:2.76E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.45|P-value:1.01E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.83|P-value:1.59E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.64|P-value:5.27E-8 ID:SGTC_2907|Compound:7721985|FD-Score:3.99|P-value:8.72E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.05|P-value:7.06E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.06|P-value:4.80E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.06|P-value:4.91E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.36|P-value:8.17E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.38|P-value:7.54E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.33|P-value:2.27E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:5.17|P-value:5.46E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:4.06|P-value:6.69E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.58|P-value:3.90E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.73|P-value:1.73E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.69|P-value:4.90E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.04|P-value:7.13E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:-3.46|P-value:4.47E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.51|P-value:4.94E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.47|P-value:5.63E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.99|P-value:6.34E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.32|P-value:9.05E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.36|P-value:7.93E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.69|P-value:3.48E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:3.70|P-value:2.54E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.73|P-value:1.72E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-4.02|P-value:5.62E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-6.51|P-value:2.49E-10 ID:SGTC_1790|Compound:st045711|FD-Score:4.86|P-value:2.32E-6 ID:SGTC_1953|Compound:st076800|FD-Score:3.31|P-value:9.45E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-4.21|P-value:2.66E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.62|P-value:3.36E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.84|P-value:1.51E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.62|P-value:3.38E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.64|P-value:3.13E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.49|P-value:5.27E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:6.00|P-value:7.36E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.68|P-value:2.76E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.45|P-value:1.01E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.83|P-value:1.59E-4 ID:SGTC_2814|Compound:7977482|FD-Score:5.64|P-value:5.27E-8 ID:SGTC_2907|Compound:7721985|FD-Score:3.99|P-value:8.72E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.05|P-value:7.06E-5 ID:SGTC_3222|Compound:9128301|FD-Score:-4.06|P-value:4.80E-5

Top fitness defect scores for YOR359W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2515 chrysin 6.00 20.8 µM 7.36E-9 RPP1 & pyrimidine depletion 1 9.76E-10
2 SGTC_2814 7977482 5.64 43.0 µM 5.27E-8 10 8.70E-9
3 SGTC_554 4483-2211 5.17 187.0 µM 5.46E-7 4 1.17E-7
4 SGTC_1790 st045711 4.86 43.5 µM 2.32E-6 7 5.85E-7
5 SGTC_952 1185-0122 4.69 232.0 µM 4.90E-6 10 1.34E-6
6 SGTC_505 gw-5074 4.33 63.9 µM 2.27E-5 46 7.39E-6
7 SGTC_577 r071-0003 4.06 38.6 µM 6.69E-5 fatty acid desaturase (OLE1) 49 2.46E-5
8 SGTC_3201 9113999 4.05 49.5 µM 7.06E-5 33 2.61E-5
9 SGTC_1156 4092-0367 4.04 4.9 µM 7.13E-5 18 2.64E-5
10 SGTC_2907 7721985 3.99 69.9 µM 8.72E-5 21 3.30E-5
11 SGTC_2284 7945075 3.84 39.2 µM 1.51E-4 mitochondrial processes 29 6.07E-5
12 SGTC_2804 7954240 3.83 19.5 µM 1.59E-4 36 6.45E-5
13 SGTC_1718 roemerine 3.70 11.9 µM 2.54E-4 redox potentiating 66 1.08E-4
14 SGTC_2573 2',4'-dihydroxychalcone 3.68 15.0 µM 2.76E-4 66 1.19E-4
15 SGTC_2322 7413319 3.64 38.2 µM 3.13E-4 ERAD & cell cycle 174 1.37E-4
16 SGTC_2273 7815444 3.62 169.1 µM 3.36E-4 33 1.48E-4
17 SGTC_2290 7904846 3.62 200.0 µM 3.38E-4 33 1.49E-4
18 SGTC_733 4069-0007 3.58 56.1 µM 3.90E-4 ERAD & cell cycle 99 1.74E-4
19 SGTC_1448 4255-0083 3.51 152.0 µM 4.94E-4 ERG2 31 2.27E-4
20 SGTC_2445 5742597 3.49 35.6 µM 5.27E-4 51 2.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.74E-15 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.099 7.78E-9 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.097 1.54E-8 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.097 2.14E-8 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 3.04E-8 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.094 4.36E-8 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.094 5.10E-8 YML022W APT1 hom Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication
0.094 5.39E-8 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.090 1.83E-7 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.090 2.03E-7 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.089 2.32E-7 YER059W PCL6 hom Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding
0.089 2.78E-7 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.088 3.12E-7 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.088 3.78E-7 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.087 4.56E-7 YHR001W-A QCR10 hom Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain