YOR360C / PDE2

High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR360C / PDE2

Click on Significant Values for Screen Details ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.17|P-value:9.12E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.58|P-value:2.25E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.52|P-value:2.71E-13 ID:SGTC_690|Compound:glyoxal|FD-Score:3.41|P-value:5.86E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.61|P-value:2.91E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.83|P-value:1.97E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:3.56|P-value:3.52E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.91|P-value:9.59E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.26|P-value:9.65E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.70|P-value:2.39E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:7.06|P-value:6.46E-12 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.52|P-value:2.81E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.08|P-value:4.92E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.40|P-value:4.20E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.28|P-value:9.01E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.69|P-value:2.24E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.65|P-value:4.41E-6 ID:SGTC_1752|Compound:st044819|FD-Score:-3.81|P-value:9.69E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.52|P-value:2.74E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.57|P-value:3.42E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.63|P-value:2.72E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.91|P-value:9.88E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.41|P-value:5.84E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.29|P-value:6.17E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.01|P-value:6.60E-5 ID:SGTC_2368|Compound:9071271|FD-Score:5.89|P-value:8.37E-9 ID:SGTC_2369|Compound:9071472|FD-Score:-3.36|P-value:4.81E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.33|P-value:5.45E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.86|P-value:7.70E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:-3.38|P-value:4.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.37|P-value:6.84E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.25|P-value:7.16E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.34|P-value:1.74E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.08|P-value:5.90E-7 ID:SGTC_2907|Compound:7721985|FD-Score:4.27|P-value:2.30E-5 ID:SGTC_2911|Compound:7942208|FD-Score:4.23|P-value:2.76E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.63|P-value:2.78E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.80|P-value:9.75E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.54|P-value:7.36E-6 ID:SGTC_2962|Compound:9082311|FD-Score:4.41|P-value:1.30E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.39|P-value:6.33E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.75|P-value:2.79E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.17|P-value:9.12E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.58|P-value:2.25E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:7.52|P-value:2.71E-13 ID:SGTC_690|Compound:glyoxal|FD-Score:3.41|P-value:5.86E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.61|P-value:2.91E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:4.83|P-value:1.97E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:3.56|P-value:3.52E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.91|P-value:9.59E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.42|P-value:5.68E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.26|P-value:9.65E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.70|P-value:2.39E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:7.06|P-value:6.46E-12 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.52|P-value:2.81E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.08|P-value:4.92E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.40|P-value:4.20E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.28|P-value:9.01E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.69|P-value:2.24E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.65|P-value:4.41E-6 ID:SGTC_1752|Compound:st044819|FD-Score:-3.81|P-value:9.69E-5 ID:SGTC_1758|Compound:st042942|FD-Score:-3.52|P-value:2.74E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.57|P-value:3.42E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.63|P-value:2.72E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.91|P-value:9.88E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.41|P-value:5.84E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-3.29|P-value:6.17E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.01|P-value:6.60E-5 ID:SGTC_2368|Compound:9071271|FD-Score:5.89|P-value:8.37E-9 ID:SGTC_2369|Compound:9071472|FD-Score:-3.36|P-value:4.81E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.33|P-value:5.45E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.86|P-value:7.70E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:-3.38|P-value:4.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.37|P-value:6.84E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.25|P-value:7.16E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.34|P-value:1.74E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.08|P-value:5.90E-7 ID:SGTC_2907|Compound:7721985|FD-Score:4.27|P-value:2.30E-5 ID:SGTC_2911|Compound:7942208|FD-Score:4.23|P-value:2.76E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.63|P-value:2.78E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.80|P-value:9.75E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.54|P-value:7.36E-6 ID:SGTC_2962|Compound:9082311|FD-Score:4.41|P-value:1.30E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.39|P-value:6.33E-4 ID:SGTC_3331|Compound:9141060|FD-Score:4.75|P-value:2.79E-6

Top fitness defect scores for YOR360C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 7.52 172.0 µM 2.71E-13 calcium & mitochondrial duress 87 2.74E-14
2 SGTC_1131 3454-3128 7.06 32.3 µM 6.46E-12 3 8.36E-13
3 SGTC_2368 9071271 5.89 200.0 µM 8.37E-9 3 1.89E-9
4 SGTC_1128 3448-9350 5.70 235.0 µM 2.39E-8 7 5.89E-9
5 SGTC_2896 9052656 5.08 71.4 µM 5.90E-7 endomembrane recycling 61 1.87E-7
6 SGTC_887 0885-0007 4.83 9.6 µM 1.97E-6 endomembrane recycling 21 6.87E-7
7 SGTC_3331 9141060 4.75 2.0 µM 2.79E-6 cell wall 18 9.99E-7
8 SGTC_1712 st032288 4.65 53.4 µM 4.41E-6 calcium & mitochondrial duress 133 1.64E-6
9 SGTC_2958 9077254 4.54 16.7 µM 7.36E-6 17 2.85E-6
10 SGTC_2962 9082311 4.41 13.2 µM 1.30E-5 9 5.28E-6
11 SGTC_2795 7780010 4.34 54.5 µM 1.74E-5 18 7.23E-6
12 SGTC_2907 7721985 4.27 69.9 µM 2.30E-5 15 9.77E-6
13 SGTC_2911 7942208 4.23 15.6 µM 2.76E-5 mitochondrial response to ROS 17 1.19E-5
14 SGTC_1443 4112-3303 4.08 14.0 µM 4.92E-5 5 2.22E-5
15 SGTC_2367 9070478 4.01 135.4 µM 6.60E-5 cell wall 30 3.04E-5
16 SGTC_1028 k015-0029 3.91 4.8 µM 9.59E-5 26 4.56E-5
17 SGTC_2068 5226020 3.91 147.0 µM 9.88E-5 31 4.71E-5
18 SGTC_794 k038-0031 3.82 316.0 µM 1.35E-4 ubiquinone biosynthesis & proteasome 113 6.61E-5
19 SGTC_1677 st019204 3.69 53.9 µM 2.24E-4 28 1.14E-4
20 SGTC_1930 st074634 3.63 34.3 µM 2.72E-4 RNA pol III & RNase P/MRP 48 1.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.307 3.96E-74 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.237 5.86E-44 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.194 6.10E-30 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.177 4.01E-25 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.174 4.09E-24 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.173 4.76E-24 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.173 5.18E-24 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.166 3.10E-22 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.158 3.07E-20 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.155 1.56E-19 YIL035C CKA1 hom Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
0.152 1.06E-18 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.147 1.00E-17 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.144 4.15E-17 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.137 1.55E-15 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.136 2.32E-15 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p