YOR374W / ALD4

Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR374W / ALD4

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:4.97|P-value:4.39E-8 ID:SGTC_489|Compound:paxilline|FD-Score:3.04|P-value:5.45E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.06|P-value:5.47E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.35|P-value:1.38E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.73|P-value:3.00E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.93|P-value:8.20E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.21|P-value:3.06E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-2.99|P-value:5.74E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.24|P-value:2.22E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.43|P-value:9.99E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.03|P-value:5.74E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.70|P-value:2.18E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-3.11|P-value:3.69E-4 ID:SGTC_1736|Compound:st036774|FD-Score:2.88|P-value:9.98E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.10|P-value:2.05E-8 ID:SGTC_2056|Compound:5235370|FD-Score:-4.48|P-value:5.93E-7 ID:SGTC_2058|Compound:5236698|FD-Score:-3.02|P-value:5.27E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.36|P-value:1.31E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.34|P-value:1.65E-4 ID:SGTC_2180|Compound:6301957|FD-Score:2.95|P-value:7.81E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.38|P-value:1.21E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.24|P-value:2.48E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.28|P-value:2.05E-6 ID:SGTC_2523|Compound:spermine|FD-Score:3.27|P-value:2.21E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.94|P-value:7.07E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.06|P-value:5.07E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.08|P-value:4.12E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.98|P-value:9.23E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.04|P-value:5.42E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.91|P-value:9.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.73|P-value:1.76E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-4.26|P-value:1.96E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-2.88|P-value:8.84E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.77|P-value:2.55E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.37|P-value:1.50E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.10|P-value:4.34E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.31|P-value:1.86E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.29|P-value:1.79E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.23|P-value:2.61E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.25|P-value:2.41E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.05|P-value:4.72E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-2.88|P-value:8.87E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.04|P-value:4.75E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.37|P-value:1.45E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.97|P-value:4.39E-8 ID:SGTC_489|Compound:paxilline|FD-Score:3.04|P-value:5.45E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.06|P-value:5.47E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.35|P-value:1.38E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.73|P-value:3.00E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.93|P-value:8.20E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.21|P-value:3.06E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-2.99|P-value:5.74E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.24|P-value:2.22E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.43|P-value:9.99E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.03|P-value:5.74E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.70|P-value:2.18E-7 ID:SGTC_1731|Compound:st035964|FD-Score:-3.11|P-value:3.69E-4 ID:SGTC_1736|Compound:st036774|FD-Score:2.88|P-value:9.98E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.10|P-value:2.05E-8 ID:SGTC_2056|Compound:5235370|FD-Score:-4.48|P-value:5.93E-7 ID:SGTC_2058|Compound:5236698|FD-Score:-3.02|P-value:5.27E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.36|P-value:1.31E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.34|P-value:1.65E-4 ID:SGTC_2180|Compound:6301957|FD-Score:2.95|P-value:7.81E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.38|P-value:1.21E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.24|P-value:2.48E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.28|P-value:2.05E-6 ID:SGTC_2523|Compound:spermine|FD-Score:3.27|P-value:2.21E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.94|P-value:7.07E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.06|P-value:5.07E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.08|P-value:4.12E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.98|P-value:9.23E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.04|P-value:5.42E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.91|P-value:9.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.73|P-value:1.76E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-4.26|P-value:1.96E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-2.88|P-value:8.84E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.77|P-value:2.55E-5 ID:SGTC_2955|Compound:9076254|FD-Score:3.37|P-value:1.50E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.10|P-value:4.34E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.31|P-value:1.86E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.29|P-value:1.79E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.23|P-value:2.61E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.25|P-value:2.41E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.05|P-value:4.72E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-2.88|P-value:8.87E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.04|P-value:4.75E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.37|P-value:1.45E-4

Top fitness defect scores for YOR374W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2049 5262831 5.10 67.2 µM 2.05E-8 9 1.71E-7
2 SGTC_50 0929-0078 4.97 56.4 µM 4.39E-8 30 3.30E-7
3 SGTC_2815 7968870 4.73 71.4 µM 1.76E-7 11 1.10E-6
4 SGTC_1699 st031318 4.70 29.1 µM 2.18E-7 15 1.32E-6
5 SGTC_2415 st077333 4.28 57.7 µM 2.05E-6 35 9.19E-6
6 SGTC_1208 2323-2347 4.21 50.3 µM 3.06E-6 3 1.30E-5
7 SGTC_2794 7785382 3.98 27.3 µM 9.23E-6 36 3.39E-5
8 SGTC_2938 9059746 3.77 27.3 µM 2.55E-5 fatty acid desaturase (OLE1) 43 8.19E-5
9 SGTC_975 1335-0046 3.73 28.5 µM 3.00E-5 RPP1 & pyrimidine depletion 46 9.43E-5
10 SGTC_3347 9188721 3.37 44.7 µM 1.45E-4 34 3.72E-4
11 SGTC_2955 9076254 3.37 12.2 µM 1.50E-4 31 3.82E-4
12 SGTC_2126 5251174 3.34 33.9 µM 1.65E-4 62 4.15E-4
13 SGTC_3019 9081971 3.31 49.5 µM 1.86E-4 28 4.62E-4
14 SGTC_2523 spermine 3.27 47.7 µM 2.21E-4 calcium & mitochondrial duress 47 5.34E-4
15 SGTC_3221 9128209 3.25 49.5 µM 2.41E-4 35 5.77E-4
16 SGTC_2372 9071633 3.24 200.0 µM 2.48E-4 30 5.92E-4
17 SGTC_3216 9129716 3.23 49.5 µM 2.61E-4 RPP1 & pyrimidine depletion 55 6.19E-4
18 SGTC_2962 9082311 3.10 13.2 µM 4.34E-4 60 9.63E-4
19 SGTC_2678 equilin 3.06 100.0 µM 5.07E-4 56 0.00110
20 SGTC_2798 7813637 3.04 45.5 µM 5.42E-4 79 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.46E-15 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 3.92E-12 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.114 3.76E-11 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.114 4.02E-11 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.111 1.35E-10 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.101 4.65E-9 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.097 2.09E-8 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.093 6.86E-8 YBR107C IML3 hom Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
0.091 1.24E-7 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.089 2.35E-7 YDR380W ARO10 hom Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
0.088 3.69E-7 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.087 4.59E-7 YPL058C PDR12 hom Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
0.086 6.04E-7 YNL063W MTQ1 hom S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
0.085 7.91E-7 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.085 8.96E-7 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane