YPL006W / NCR1

Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL006W / NCR1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.14|P-value:2.17E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.73|P-value:2.64E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.96|P-value:8.84E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:3.20|P-value:7.89E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.26|P-value:8.91E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.52|P-value:3.66E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.95|P-value:7.51E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.81|P-value:1.25E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.63|P-value:1.68E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.41|P-value:5.39E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.83|P-value:7.81E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.71|P-value:1.26E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.57|P-value:2.11E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.24|P-value:6.75E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.31|P-value:1.12E-5 ID:SGTC_1571|Compound:st070080|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.19|P-value:8.11E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.97|P-value:4.52E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.65|P-value:3.74E-6 ID:SGTC_1749|Compound:st037932|FD-Score:4.94|P-value:6.08E-7 ID:SGTC_1750|Compound:st081859|FD-Score:4.51|P-value:4.52E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.64|P-value:1.61E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.24|P-value:6.91E-4 ID:SGTC_2122|Compound:5258151|FD-Score:6.66|P-value:3.34E-11 ID:SGTC_2170|Compound:morpholine|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.66|P-value:2.31E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.05|P-value:3.34E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.34|P-value:4.76E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:6.46|P-value:1.21E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.13|P-value:9.94E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:5.02|P-value:4.08E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.49|P-value:2.89E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.93|P-value:5.43E-5 ID:SGTC_3130|Compound:9127414|FD-Score:4.71|P-value:1.82E-6 ID:SGTC_3204|Compound:9114183|FD-Score:3.41|P-value:3.81E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.70|P-value:1.30E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.14|P-value:2.17E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.73|P-value:2.64E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.96|P-value:8.84E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:3.20|P-value:7.89E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.26|P-value:8.91E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.52|P-value:3.66E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.95|P-value:7.51E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.81|P-value:1.25E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.63|P-value:1.68E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.41|P-value:5.39E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.83|P-value:7.81E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.71|P-value:1.26E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.57|P-value:2.11E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.24|P-value:6.75E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.31|P-value:1.12E-5 ID:SGTC_1571|Compound:st070080|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.19|P-value:8.11E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.97|P-value:4.52E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-4.65|P-value:3.74E-6 ID:SGTC_1749|Compound:st037932|FD-Score:4.94|P-value:6.08E-7 ID:SGTC_1750|Compound:st081859|FD-Score:4.51|P-value:4.52E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.64|P-value:1.61E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.24|P-value:6.91E-4 ID:SGTC_2122|Compound:5258151|FD-Score:6.66|P-value:3.34E-11 ID:SGTC_2170|Compound:morpholine|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.66|P-value:2.31E-6 ID:SGTC_2369|Compound:9071472|FD-Score:4.05|P-value:3.34E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.34|P-value:4.76E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:6.46|P-value:1.21E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.13|P-value:9.94E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:5.02|P-value:4.08E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.49|P-value:2.89E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.93|P-value:5.43E-5 ID:SGTC_3130|Compound:9127414|FD-Score:4.71|P-value:1.82E-6 ID:SGTC_3204|Compound:9114183|FD-Score:3.41|P-value:3.81E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.70|P-value:1.30E-4

Top fitness defect scores for YPL006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2122 5258151 6.66 111.7 µM 3.34E-11 3 1.40E-11
2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 6.46 63.6 µM 1.21E-10 9 5.41E-11
3 SGTC_35 0133-0054 5.14 64.1 µM 2.17E-7 9 1.36E-7
4 SGTC_2606 farnesol 5.02 9.8 µM 4.08E-7 7 2.63E-7
5 SGTC_1749 st037932 4.94 54.2 µM 6.08E-7 19 3.99E-7
6 SGTC_3130 9127414 4.71 49.5 µM 1.82E-6 11 1.25E-6
7 SGTC_2179 6298986 4.66 200.0 µM 2.31E-6 heme requiring 9 1.61E-6
8 SGTC_1750 st081859 4.51 2.4 µM 4.52E-6 endomembrane recycling 152 3.24E-6
9 SGTC_1545 lovastatin 4.31 49.4 µM 1.12E-5 15 8.30E-6
10 SGTC_2369 9071472 4.05 200.0 µM 3.34E-5 13 2.60E-5
11 SGTC_1591 genipin 3.97 88.4 µM 4.52E-5 mitochondrial processes 12 3.56E-5
12 SGTC_2840 9008771 3.93 71.4 µM 5.43E-5 10 4.32E-5
13 SGTC_1085 doxorubicin 3.83 7.7 µM 7.81E-5 anthracycline transcription coupled DNA repair 21 6.29E-5
14 SGTC_1189 1431-2119 3.71 7.3 µM 1.26E-4 35 1.04E-4
15 SGTC_3349 9149703 3.70 23.0 µM 1.30E-4 21 1.07E-4
16 SGTC_2042 p-Dimethylaminoacetophenone 3.64 200.0 µM 1.61E-4 27 1.34E-4
17 SGTC_501 nsc-95397 3.64 161.0 µM 1.67E-4 19 1.38E-4
18 SGTC_754 3474-0146 3.63 171.0 µM 1.68E-4 copper-dependent oxidative stress 37 1.40E-4
19 SGTC_1571 st070080 3.59 73.4 µM 2.01E-4 28 1.68E-4
20 SGTC_1305 1181-0477 3.57 144.0 µM 2.11E-4 25 1.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.12E-15 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.129 5.91E-14 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.112 6.80E-11 YPR153W YPR153W hom Putative protein of unknown function
0.103 2.40E-9 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.096 2.30E-8 YKL092C BUD2 hom GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint
0.094 5.03E-8 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
0.093 6.18E-8 YER078C ICP55 hom Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
0.090 1.57E-7 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.088 3.45E-7 YCR016W_p YCR016W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis
0.081 2.73E-6 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.26E-6 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.079 5.05E-6 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.076 1.07E-5 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1
0.074 1.60E-5 YKL044W_p YKL044W_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.074 2.01E-5 YIR039C YPS6 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance