TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPL011C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.174 | 2.98E-24 | YLR315W | NKP2 | hom | Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 |
0.154 | 2.39E-19 | YAL059W | ECM1 | hom | Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm |
0.151 | 1.49E-18 | YBR080C | SEC18 | het | ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF |
0.144 | 5.78E-17 | YHR195W | NVJ1 | hom | Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) |
0.129 | 6.06E-14 | YGR085C | RPL11B | hom | Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication |
0.121 | 1.67E-12 | YOR073W | SGO1 | hom | Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability |
0.119 | 5.90E-12 | YFL001W | DEG1 | hom | tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability |
0.118 | 6.52E-12 | YDR541C_p | YDR541C_p | hom | Putative dihydrokaempferol 4-reductase |
0.115 | 2.31E-11 | YKR083C | DAD2 | het | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
0.114 | 3.57E-11 | YPL054W | LEE1 | hom | Zinc-finger protein of unknown function |
0.112 | 7.26E-11 | YOL013C | HRD1 | hom | Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon |
0.111 | 1.17E-10 | YAL047C | SPC72 | hom | Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization |
0.108 | 3.03E-10 | YBR189W | RPS9B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication |
0.107 | 4.74E-10 | YMR092C | AIP1 | hom | Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress |
0.102 | 3.41E-9 | YNL310C | ZIM17 | het | Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix |