YPL011C / TAF3

TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL011C / TAF3

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.66|P-value:3.64E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.68|P-value:1.74E-7 ID:SGTC_715|Compound:0868-0130|FD-Score:3.04|P-value:3.55E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:2.98|P-value:4.61E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.01|P-value:4.01E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:2.93|P-value:5.57E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.00|P-value:5.73E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:2.96|P-value:5.04E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.15|P-value:3.22E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.04|P-value:3.77E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.45|P-value:9.04E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.91|P-value:8.11E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.94|P-value:5.34E-4 ID:SGTC_1567|Compound:st069303|FD-Score:5.55|P-value:4.18E-10 ID:SGTC_1569|Compound:carminic acid|FD-Score:-2.94|P-value:7.33E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.26|P-value:1.48E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.83|P-value:8.09E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.97|P-value:6.55E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.16|P-value:3.13E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.22|P-value:2.47E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.62|P-value:2.96E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.84|P-value:7.76E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.07|P-value:3.16E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.02|P-value:3.92E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.51|P-value:4.91E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.27|P-value:1.39E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.03|P-value:3.79E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.88|P-value:9.06E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.65|P-value:2.62E-5 ID:SGTC_2345|Compound:9052315|FD-Score:2.84|P-value:7.82E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.28|P-value:1.34E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.19|P-value:2.72E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.40|P-value:8.11E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.26|P-value:1.47E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.83|P-value:8.06E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.08|P-value:3.11E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.26|P-value:1.49E-4 ID:SGTC_3069|Compound:9117009|FD-Score:2.92|P-value:5.70E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.66|P-value:3.64E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.68|P-value:1.74E-7 ID:SGTC_715|Compound:0868-0130|FD-Score:3.04|P-value:3.55E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:2.98|P-value:4.61E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.01|P-value:4.01E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:2.93|P-value:5.57E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.00|P-value:5.73E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:2.96|P-value:5.04E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.15|P-value:3.22E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.04|P-value:3.77E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.45|P-value:9.04E-5 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.91|P-value:8.11E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:2.94|P-value:5.34E-4 ID:SGTC_1567|Compound:st069303|FD-Score:5.55|P-value:4.18E-10 ID:SGTC_1569|Compound:carminic acid|FD-Score:-2.94|P-value:7.33E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.26|P-value:1.48E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.83|P-value:8.09E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.97|P-value:6.55E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.16|P-value:3.13E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.22|P-value:2.47E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.62|P-value:2.96E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.84|P-value:7.76E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.07|P-value:3.16E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.02|P-value:3.92E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.51|P-value:4.91E-5 ID:SGTC_1959|Compound:st077091|FD-Score:3.27|P-value:1.39E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.03|P-value:3.79E-4 ID:SGTC_2122|Compound:5258151|FD-Score:-2.88|P-value:9.06E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.65|P-value:2.62E-5 ID:SGTC_2345|Compound:9052315|FD-Score:2.84|P-value:7.82E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.28|P-value:1.34E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.19|P-value:2.72E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.40|P-value:8.11E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.26|P-value:1.47E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.83|P-value:8.06E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.08|P-value:3.11E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.26|P-value:1.49E-4 ID:SGTC_3069|Compound:9117009|FD-Score:2.92|P-value:5.70E-4

Top fitness defect scores for YPL011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1567 st069303 5.55 68.4 µM 4.18E-10 mitochondrial processes 4 1.41E-8 0.13
2 SGTC_1224 0823-0416 4.04 294.0 µM 3.77E-6 3 2.68E-5 0.60
3 SGTC_2325 6158266 3.65 200.0 µM 2.62E-5 9 1.34E-4 0.24
4 SGTC_1784 st039334 3.62 36.3 µM 2.96E-5 12 1.48E-4 0.02
5 SGTC_1916 st067606 3.51 49.2 µM 4.91E-5 11 2.25E-4 0.06
6 SGTC_2566 crystal violet carbinol 3.40 226.0 nM 8.11E-5 30 3.42E-4 0.07
7 SGTC_2377 9073351 3.28 62.6 µM 1.34E-4 ergosterol biosynthesis 13 5.18E-4 0.02
8 SGTC_1959 st077091 3.27 55.8 µM 1.39E-4 RPP1 & pyrimidine depletion 33 5.35E-4 0.04
9 SGTC_2610 ononetin 3.26 44.2 µM 1.47E-4 11 5.60E-4 0.14
10 SGTC_1583 clindamycin 3.26 39.6 µM 1.48E-4 mitochondrial processes 13 5.64E-4 0.10
11 SGTC_3064 1327-0027 3.26 10.0 µM 1.49E-4 8 5.65E-4 0.11
12 SGTC_2973 9094665 3.08 18.0 µM 3.11E-4 NEO1 28 0.00105 0.05
13 SGTC_1851 st056236 3.07 18.9 µM 3.16E-4 18 0.00106 0.03
14 SGTC_715 0868-0130 3.04 184.0 µM 3.55E-4 3 0.00117 0.03
15 SGTC_2075 5212009 3.03 200.0 µM 3.79E-4 13 0.00123 0.04
16 SGTC_1861 st057647 3.02 17.4 µM 3.92E-4 14 0.00127 0.22
17 SGTC_851 0394-0702 3.01 453.0 µM 4.01E-4 mitochondrial processes 35 0.00129 0.05
18 SGTC_808 0711-0032 2.98 135.0 µM 4.61E-4 23 0.00145 0.02
19 SGTC_1116 jasmonic acid 2.96 1.6 µM 5.04E-4 13 0.00156 0.09
20 SGTC_1562 morin hydrate 2.94 59.1 µM 5.34E-4 17 0.00164 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.98E-24 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.154 2.39E-19 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.151 1.49E-18 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.144 5.78E-17 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.129 6.06E-14 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.121 1.67E-12 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.119 5.90E-12 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.118 6.52E-12 YDR541C_p YDR541C_p hom Putative dihydrokaempferol 4-reductase
0.115 2.31E-11 YKR083C DAD2 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.114 3.57E-11 YPL054W LEE1 hom Zinc-finger protein of unknown function
0.112 7.26E-11 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.111 1.17E-10 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.108 3.03E-10 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.107 4.74E-10 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.102 3.41E-9 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix