HIPHOP chemogenomics database

YPL013C / MRPS16

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL013C / MRPS16

Click on Significant Values for Screen Details

Top fitness defect scores for YPL013C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1635	st007035	34.00	42.4 µM	8.42E-222		5	4.43E-254
2	SGTC_236	1509-0011	33.90	5.3 µM	8.86E-221		4	6.58E-253
3	SGTC_386	1509-0011	20.80	3.1 µM	4.43E-84		7	3.46E-96
4	SGTC_134	0269-0018	12.30	6.9 µM	1.23E-30		29	6.51E-35
5	SGTC_275	trichlorophene	11.80	5.7 µM	1.60E-28	mitochondrial stress	22	1.74E-32
6	SGTC_70	0141-0289	6.67	43.3 µM	2.62E-10	mitochondrial stress	57	1.30E-11
7	SGTC_1188	1403-0014	5.81	4.6 µM	3.12E-8	mitochondrial stress	19	3.12E-9
8	SGTC_435	c-PAF	5.76	6.7 µM	4.08E-8		10	4.23E-9
9	SGTC_100	0086-0128	5.70	49.6 µM	5.40E-8	copper-dependent oxidative stress	17	5.84E-9
10	SGTC_2582	agaric acid	5.61	100.0 µM	8.95E-8	redox potentiating	182	1.04E-8
11	SGTC_84	0443-0269	5.60	128.8 µM	9.06E-8		5	1.05E-8
12	SGTC_365	0121-0052	5.34	13.6 µM	3.27E-7	mitochondrial response to ROS	21	4.58E-8
13	SGTC_1173	0443-0020	5.31	122.0 µM	3.84E-7	TSC3-RPN4	18	5.51E-8
14	SGTC_87	0100-0052	5.01	35.5 µM	1.57E-6		54	2.76E-7
15	SGTC_2949	9072542	4.93	2.2 µM	2.21E-6	TSC3-RPN4	14	4.08E-7
16	SGTC_1894	3',6'-dihydroxyflavone	4.62	78.7 µM	8.60E-6		7	1.93E-6
17	SGTC_769	0302-0231	4.44	76.0 µM	1.77E-5		27	4.42E-6
18	SGTC_2022	5136654	4.27	200.0 µM	3.59E-5		16	9.89E-6
19	SGTC_530	4358-1714	4.06	28.0 µM	8.00E-5		43	2.47E-5
20	SGTC_807	1315-0151	4.05	48.0 µM	8.33E-5		25	2.59E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	ORF	Gene	Zygosity	Description
0.762	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.756	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.751	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.735	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.730	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.729	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.725	YJL022W_d	YJL022W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.723	YLL009C	COX17	hom	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.711	YNR045W	PET494	hom	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.709	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.706	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.706	YKL194C	MST1	hom	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.695	YKL155C	RSM22	hom	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.684	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.683	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex