YPL013C / MRPS16

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL013C / MRPS16

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.63|P-value:3.63E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.97|P-value:1.10E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.67|P-value:2.62E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:3.75|P-value:2.43E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:5.60|P-value:9.06E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:5.01|P-value:1.57E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:5.70|P-value:5.40E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:12.30|P-value:1.23E-30 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.11|P-value:5.86E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.46|P-value:6.44E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.30|P-value:9.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:33.90|P-value:8.86E-221 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.80|P-value:1.60E-28 ID:SGTC_283|Compound:0987-0079|FD-Score:3.52|P-value:5.26E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.62|P-value:3.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.50|P-value:5.68E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.34|P-value:3.27E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:20.80|P-value:4.43E-84 ID:SGTC_435|Compound:c-PAF|FD-Score:5.76|P-value:4.08E-8 ID:SGTC_530|Compound:4358-1714|FD-Score:4.06|P-value:8.00E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.44|P-value:1.77E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:-4.23|P-value:3.59E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.05|P-value:8.33E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.38|P-value:8.46E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.37|P-value:7.90E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.31|P-value:3.84E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.78|P-value:1.94E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.81|P-value:3.12E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.99|P-value:9.22E-5 ID:SGTC_1635|Compound:st007035|FD-Score:34.00|P-value:8.42E-222 ID:SGTC_1712|Compound:st032288|FD-Score:-3.84|P-value:1.57E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.98|P-value:1.54E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.72|P-value:2.44E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.38|P-value:8.39E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.62|P-value:8.60E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-6.23|P-value:2.62E-9 ID:SGTC_2022|Compound:5136654|FD-Score:4.27|P-value:3.59E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-5.42|P-value:1.93E-7 ID:SGTC_2053|Compound:5265679|FD-Score:3.47|P-value:6.30E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.85|P-value:1.69E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.45|P-value:5.96E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.78|P-value:1.93E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.56|P-value:4.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.61|P-value:8.95E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.68|P-value:3.14E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.40|P-value:7.11E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.93|P-value:2.21E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.53|P-value:5.14E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.61|P-value:3.95E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.63|P-value:3.63E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.97|P-value:1.10E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.67|P-value:2.62E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:3.75|P-value:2.43E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:5.60|P-value:9.06E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:5.01|P-value:1.57E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:5.70|P-value:5.40E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:12.30|P-value:1.23E-30 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.11|P-value:5.86E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.46|P-value:6.44E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.30|P-value:9.66E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:33.90|P-value:8.86E-221 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.80|P-value:1.60E-28 ID:SGTC_283|Compound:0987-0079|FD-Score:3.52|P-value:5.26E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.62|P-value:3.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.50|P-value:5.68E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.34|P-value:3.27E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:20.80|P-value:4.43E-84 ID:SGTC_435|Compound:c-PAF|FD-Score:5.76|P-value:4.08E-8 ID:SGTC_530|Compound:4358-1714|FD-Score:4.06|P-value:8.00E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.44|P-value:1.77E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:-4.23|P-value:3.59E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.05|P-value:8.33E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.38|P-value:8.46E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.37|P-value:7.90E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.31|P-value:3.84E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.78|P-value:1.94E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.81|P-value:3.12E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.99|P-value:9.22E-5 ID:SGTC_1635|Compound:st007035|FD-Score:34.00|P-value:8.42E-222 ID:SGTC_1712|Compound:st032288|FD-Score:-3.84|P-value:1.57E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.98|P-value:1.54E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.72|P-value:2.44E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.38|P-value:8.39E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.62|P-value:8.60E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-6.23|P-value:2.62E-9 ID:SGTC_2022|Compound:5136654|FD-Score:4.27|P-value:3.59E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-5.42|P-value:1.93E-7 ID:SGTC_2053|Compound:5265679|FD-Score:3.47|P-value:6.30E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.85|P-value:1.69E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.68|P-value:3.12E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.45|P-value:5.96E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.78|P-value:1.93E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.56|P-value:4.18E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.61|P-value:8.95E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.68|P-value:3.14E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.40|P-value:7.11E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.93|P-value:2.21E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.53|P-value:5.14E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.61|P-value:3.95E-4

Top fitness defect scores for YPL013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 34.00 42.4 µM 8.42E-222 5 4.43E-254
2 SGTC_236 1509-0011 33.90 5.3 µM 8.86E-221 4 6.58E-253
3 SGTC_386 1509-0011 20.80 3.1 µM 4.43E-84 7 3.46E-96
4 SGTC_134 0269-0018 12.30 6.9 µM 1.23E-30 29 6.51E-35
5 SGTC_275 trichlorophene 11.80 5.7 µM 1.60E-28 mitochondrial stress 22 1.74E-32
6 SGTC_70 0141-0289 6.67 43.3 µM 2.62E-10 mitochondrial stress 57 1.30E-11
7 SGTC_1188 1403-0014 5.81 4.6 µM 3.12E-8 mitochondrial stress 19 3.12E-9
8 SGTC_435 c-PAF 5.76 6.7 µM 4.08E-8 10 4.23E-9
9 SGTC_100 0086-0128 5.70 49.6 µM 5.40E-8 copper-dependent oxidative stress 17 5.84E-9
10 SGTC_2582 agaric acid 5.61 100.0 µM 8.95E-8 redox potentiating 182 1.04E-8
11 SGTC_84 0443-0269 5.60 128.8 µM 9.06E-8 5 1.05E-8
12 SGTC_365 0121-0052 5.34 13.6 µM 3.27E-7 mitochondrial response to ROS 21 4.58E-8
13 SGTC_1173 0443-0020 5.31 122.0 µM 3.84E-7 TSC3-RPN4 18 5.51E-8
14 SGTC_87 0100-0052 5.01 35.5 µM 1.57E-6 54 2.76E-7
15 SGTC_2949 9072542 4.93 2.2 µM 2.21E-6 TSC3-RPN4 14 4.08E-7
16 SGTC_1894 3',6'-dihydroxyflavone 4.62 78.7 µM 8.60E-6 7 1.93E-6
17 SGTC_769 0302-0231 4.44 76.0 µM 1.77E-5 27 4.42E-6
18 SGTC_2022 5136654 4.27 200.0 µM 3.59E-5 16 9.89E-6
19 SGTC_530 4358-1714 4.06 28.0 µM 8.00E-5 43 2.47E-5
20 SGTC_807 1315-0151 4.05 48.0 µM 8.33E-5 25 2.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.762 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.756 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.751 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.735 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.730 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.729 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.725 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.723 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.711 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.709 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.706 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.706 0 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.695 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.684 0 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.683 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex