YPL021W / ECM23

Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL021W / ECM23

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:2.86|P-value:8.81E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.34|P-value:1.74E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.53|P-value:5.97E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.58|P-value:2.99E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.10|P-value:3.54E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.24|P-value:2.05E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.36|P-value:1.21E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.05|P-value:4.33E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.20|P-value:2.39E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.49|P-value:6.95E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:2.96|P-value:5.98E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:2.95|P-value:6.36E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.09|P-value:3.72E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.60|P-value:4.38E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.58|P-value:4.78E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.89|P-value:7.99E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.23|P-value:2.07E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.01|P-value:5.09E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.01|P-value:5.10E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.89|P-value:5.19E-8 ID:SGTC_2218|Compound:6965428|FD-Score:4.37|P-value:9.71E-7 ID:SGTC_2270|Compound:7924575|FD-Score:-2.95|P-value:7.98E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.12|P-value:4.30E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.46|P-value:7.84E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.01|P-value:4.96E-4 ID:SGTC_2671|Compound:danthron|FD-Score:2.99|P-value:5.31E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.18|P-value:2.57E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.45|P-value:8.26E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-4.14|P-value:4.44E-6 ID:SGTC_2802|Compound:7925815|FD-Score:4.28|P-value:1.59E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.98|P-value:1.00E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.23|P-value:2.10E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.66|P-value:4.43E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.72|P-value:3.34E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.58|P-value:6.31E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-4.97|P-value:4.67E-8 ID:SGTC_2997|Compound:9067075|FD-Score:3.41|P-value:9.93E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.33|P-value:1.39E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.71|P-value:2.61E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.89|P-value:1.12E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.99|P-value:6.81E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:2.86|P-value:8.81E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.34|P-value:1.74E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.53|P-value:5.97E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.58|P-value:2.99E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.10|P-value:3.54E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.24|P-value:2.05E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.36|P-value:1.21E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.05|P-value:4.33E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.20|P-value:2.39E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.49|P-value:6.95E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:2.96|P-value:5.98E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:2.95|P-value:6.36E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.09|P-value:3.72E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.60|P-value:4.38E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.58|P-value:4.78E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.89|P-value:7.99E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.23|P-value:2.07E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.01|P-value:5.09E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.01|P-value:5.10E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.89|P-value:5.19E-8 ID:SGTC_2218|Compound:6965428|FD-Score:4.37|P-value:9.71E-7 ID:SGTC_2270|Compound:7924575|FD-Score:-2.95|P-value:7.98E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.12|P-value:4.30E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.46|P-value:7.84E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.01|P-value:4.96E-4 ID:SGTC_2671|Compound:danthron|FD-Score:2.99|P-value:5.31E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.18|P-value:2.57E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.45|P-value:8.26E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-4.14|P-value:4.44E-6 ID:SGTC_2802|Compound:7925815|FD-Score:4.28|P-value:1.59E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-3.98|P-value:1.00E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.23|P-value:2.10E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.66|P-value:4.43E-5 ID:SGTC_2897|Compound:9048598|FD-Score:-3.72|P-value:3.34E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.58|P-value:6.31E-5 ID:SGTC_2996|Compound:9066192|FD-Score:-4.97|P-value:4.67E-8 ID:SGTC_2997|Compound:9067075|FD-Score:3.41|P-value:9.93E-5 ID:SGTC_2999|Compound:9069765|FD-Score:3.33|P-value:1.39E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.71|P-value:2.61E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.89|P-value:1.12E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.99|P-value:6.81E-6

Top fitness defect scores for YPL021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2138 5575593 4.89 77.7 µM 5.19E-8 2 5.10E-7
2 SGTC_396 dithiazanine 4.58 1.2 µM 2.99E-7 4 2.28E-6
3 SGTC_2218 6965428 4.37 193.0 µM 9.71E-7 TSC3-RPN4 7 6.24E-6
4 SGTC_2802 7925815 4.28 54.5 µM 1.59E-6 32 9.52E-6
5 SGTC_1494 4358-1428 4.23 177.0 µM 2.07E-6 14 1.19E-5
6 SGTC_3271 9137798 3.99 49.5 µM 6.81E-6 4 3.30E-5
7 SGTC_3129 9127257 3.89 49.5 µM 1.12E-5 23 5.03E-5
8 SGTC_3061 glucosamine 3.71 200.0 µM 2.61E-5 14 1.04E-4
9 SGTC_1034 k072-0165 3.60 12.7 µM 4.38E-5 Golgi 33 1.62E-4
10 SGTC_1041 0206-0046 3.58 107.0 µM 4.78E-5 44 1.75E-4
11 SGTC_281 1672-3440 3.53 14.9 µM 5.97E-5 Golgi 9 2.11E-4
12 SGTC_911 3456-4043 3.49 236.0 µM 6.95E-5 mitochondrial processes 41 2.41E-4
13 SGTC_2476 5806916 3.46 10.5 µM 7.84E-5 26 2.67E-4
14 SGTC_2781 5567276 3.45 71.4 µM 8.26E-5 78 2.79E-4
15 SGTC_2997 9067075 3.41 71.4 µM 9.93E-5 unfolded protein response 75 3.26E-4
16 SGTC_701 4424-0219 3.36 185.0 µM 1.21E-4 calcium & mitochondrial duress 31 3.88E-4
17 SGTC_2999 9069765 3.33 71.4 µM 1.39E-4 amide catabolism 53 4.35E-4
18 SGTC_671 0560-0003 3.24 407.0 µM 2.05E-4 33 6.08E-4
19 SGTC_2893 9048488 3.23 26.0 µM 2.10E-4 fatty acid desaturase (OLE1) 44 6.20E-4
20 SGTC_867 0518-0118 3.20 155.0 µM 2.39E-4 DNA intercalators 50 6.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.14E-16 YER036C ARB1 het ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
0.112 8.75E-11 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.097 1.61E-8 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.090 1.81E-7 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.39E-6 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.39E-6 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.082 1.77E-6 YOR148C SPP2 het Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
0.082 2.26E-6 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.079 4.67E-6 YLL020C_d YLL020C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
0.078 5.47E-6 YKL163W PIR3 hom O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
0.078 5.55E-6 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
0.077 7.69E-6 YAL042C-A_d YAL042C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene
0.077 8.59E-6 YMR086C-A_d YMR086C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 2.02E-5 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.073 2.34E-5 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member