YPL026C / SKS1

Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL026C / SKS1

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:2.84|P-value:2.84E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.65|P-value:1.10E-5 ID:SGTC_271|Compound:rotenone|FD-Score:2.63|P-value:6.70E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.25|P-value:4.11E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.23|P-value:8.75E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:2.56|P-value:9.15E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:2.81|P-value:3.23E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.60|P-value:7.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.82|P-value:3.08E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.52|P-value:1.01E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:-2.81|P-value:5.70E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:2.62|P-value:7.08E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.22|P-value:4.36E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.11|P-value:8.17E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:2.89|P-value:2.27E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-2.68|P-value:9.96E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.50|P-value:7.65E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:-5.51|P-value:5.61E-11 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.69|P-value:9.53E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.25|P-value:4.15E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.97|P-value:1.59E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.76|P-value:3.95E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:2.73|P-value:4.40E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.90|P-value:3.94E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-4.30|P-value:2.66E-7 ID:SGTC_1897|Compound:st060201|FD-Score:-3.27|P-value:7.27E-5 ID:SGTC_2297|Compound:7971671|FD-Score:6.70|P-value:4.72E-16 ID:SGTC_2401|Compound:5128683|FD-Score:2.55|P-value:9.36E-4 ID:SGTC_2517|Compound:totarol|FD-Score:2.77|P-value:3.70E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:2.54|P-value:9.79E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.37|P-value:2.25E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.26|P-value:3.90E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.38|P-value:2.10E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.00|P-value:2.52E-4 ID:SGTC_3009|Compound:9080819|FD-Score:2.54|P-value:9.66E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:2.84|P-value:2.84E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.65|P-value:1.10E-5 ID:SGTC_271|Compound:rotenone|FD-Score:2.63|P-value:6.70E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.25|P-value:4.11E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.23|P-value:8.75E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:2.56|P-value:9.15E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:2.81|P-value:3.23E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.60|P-value:7.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.82|P-value:3.08E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.52|P-value:1.01E-5 ID:SGTC_505|Compound:gw-5074|FD-Score:-2.81|P-value:5.70E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:2.62|P-value:7.08E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.22|P-value:4.36E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.11|P-value:8.17E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:2.89|P-value:2.27E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-2.68|P-value:9.96E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.50|P-value:7.65E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:-5.51|P-value:5.61E-11 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-2.69|P-value:9.53E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.25|P-value:4.15E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.97|P-value:1.59E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.76|P-value:3.95E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:2.73|P-value:4.40E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.90|P-value:3.94E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-4.30|P-value:2.66E-7 ID:SGTC_1897|Compound:st060201|FD-Score:-3.27|P-value:7.27E-5 ID:SGTC_2297|Compound:7971671|FD-Score:6.70|P-value:4.72E-16 ID:SGTC_2401|Compound:5128683|FD-Score:2.55|P-value:9.36E-4 ID:SGTC_2517|Compound:totarol|FD-Score:2.77|P-value:3.70E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:2.54|P-value:9.79E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.37|P-value:2.25E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.26|P-value:3.90E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.38|P-value:2.10E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.00|P-value:2.52E-4 ID:SGTC_3009|Compound:9080819|FD-Score:2.54|P-value:9.66E-4

Top fitness defect scores for YPL026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2297 7971671 6.70 152.3 µM 4.72E-16 RNA processing & uracil transport 5 1.01E-11
2 SGTC_503 tyrphostin 8 3.52 294.0 µM 1.01E-5 TSC3-RPN4 47 2.12E-4
3 SGTC_2845 9003024 3.38 43.0 µM 2.10E-5 amide catabolism 70 3.58E-4
4 SGTC_2690 usnic acid 3.37 100.0 µM 2.25E-5 50 3.75E-4
5 SGTC_2703 st077852 3.26 53.4 µM 3.90E-5 53 5.56E-4
6 SGTC_344 k064-0035 3.25 6.4 µM 4.11E-5 60S ribosome export 50 5.77E-4
7 SGTC_1136 pergolide 3.25 1.1 µM 4.15E-5 73 5.81E-4
8 SGTC_848 0368-0089 3.11 85.6 µM 8.17E-5 iron homeostasis 39 9.40E-4
9 SGTC_1201 1889-3372 2.97 45.9 µM 1.59E-4 Golgi 37 0.00151
10 SGTC_875 0709-0210 2.89 25.7 µM 2.27E-4 fatty acid desaturase (OLE1) 79 0.00195
11 SGTC_164 4100-3994 2.84 89.6 µM 2.84E-4 102 0.00228
12 SGTC_453 enantio-paf c16 2.82 10.0 µM 3.08E-4 275 0.00242
13 SGTC_432 NS 1619 2.81 61.3 µM 3.23E-4 91 0.00250
14 SGTC_2517 totarol 2.77 10.0 µM 3.70E-4 79 0.00276
15 SGTC_1206 3978-0017 2.76 132.0 µM 3.95E-4 ERG2 93 0.00289
16 SGTC_1285 0929-0069 2.73 65.5 µM 4.40E-4 92 0.00312
17 SGTC_271 rotenone 2.63 740.0 µM 6.70E-4 115 0.00422
18 SGTC_514 4466-0038 2.62 2.6 nM 7.08E-4 cell wall 268 0.00439
19 SGTC_435 c-PAF 2.60 6.7 µM 7.67E-4 138 0.00465
20 SGTC_358 0075-0058 2.56 9.4 µM 9.15E-4 198 0.00527

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.47E-28 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.139 6.42E-16 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.139 7.66E-16 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.138 1.05E-15 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.130 4.90E-14 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.127 1.79E-13 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.126 2.80E-13 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.56E-12 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.120 3.37E-12 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.119 5.19E-12 YMR291W TDA1 hom Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.118 6.14E-12 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.117 9.88E-12 YDR242W AMD2 hom Putative amidase
0.116 1.42E-11 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.111 1.09E-10 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.109 2.33E-10 YML027W YOX1 hom Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication