YPL035C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL035C / YPL035C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.89|P-value:5.52E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:3.18|P-value:7.90E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.31|P-value:5.06E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.95|P-value:4.35E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:10.00|P-value:9.30E-24 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.38|P-value:3.87E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.86|P-value:6.26E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.62|P-value:2.16E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.85|P-value:5.78E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.96|P-value:4.15E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.26|P-value:6.05E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.87|P-value:5.94E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.40|P-value:3.67E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.67|P-value:1.31E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.35|P-value:4.36E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.22|P-value:6.90E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.27|P-value:1.09E-5 ID:SGTC_1732|Compound:st034308|FD-Score:5.33|P-value:5.74E-8 ID:SGTC_1739|Compound:st037196|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.40|P-value:3.63E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.37|P-value:3.67E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.09|P-value:2.34E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.46|P-value:4.61E-6 ID:SGTC_1966|Compound:st070145|FD-Score:3.25|P-value:6.25E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.35|P-value:4.36E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.68|P-value:1.28E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.14|P-value:8.97E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.48|P-value:2.48E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.26|P-value:5.47E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.78|P-value:8.66E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-5.78|P-value:3.90E-9 ID:SGTC_2921|Compound:7974240|FD-Score:4.38|P-value:6.45E-6 ID:SGTC_2927|Compound:9011802|FD-Score:6.19|P-value:3.52E-10 ID:SGTC_3033|Compound:9090887|FD-Score:3.59|P-value:1.77E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-4.56|P-value:2.56E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.64|P-value:1.48E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.35|P-value:4.41E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.89|P-value:5.52E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:3.18|P-value:7.90E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.31|P-value:5.06E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.95|P-value:4.35E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:10.00|P-value:9.30E-24 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.38|P-value:3.87E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.86|P-value:6.26E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.62|P-value:2.16E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.85|P-value:5.78E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.96|P-value:4.15E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.26|P-value:6.05E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.87|P-value:5.94E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.40|P-value:3.67E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.67|P-value:1.31E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.35|P-value:4.36E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.22|P-value:6.90E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.27|P-value:1.09E-5 ID:SGTC_1732|Compound:st034308|FD-Score:5.33|P-value:5.74E-8 ID:SGTC_1739|Compound:st037196|FD-Score:3.12|P-value:9.77E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.40|P-value:3.63E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.37|P-value:3.67E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.09|P-value:2.34E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.46|P-value:4.61E-6 ID:SGTC_1966|Compound:st070145|FD-Score:3.25|P-value:6.25E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.35|P-value:4.36E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.68|P-value:1.28E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.14|P-value:8.97E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.48|P-value:2.48E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.26|P-value:5.47E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.78|P-value:8.66E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-5.78|P-value:3.90E-9 ID:SGTC_2921|Compound:7974240|FD-Score:4.38|P-value:6.45E-6 ID:SGTC_2927|Compound:9011802|FD-Score:6.19|P-value:3.52E-10 ID:SGTC_3033|Compound:9090887|FD-Score:3.59|P-value:1.77E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-4.56|P-value:2.56E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.64|P-value:1.48E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.35|P-value:4.41E-4

Top fitness defect scores for YPL035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 10.00 24.7 µM 9.30E-24 7 6.34E-24
2 SGTC_2927 9011802 6.19 47.9 µM 3.52E-10 3 2.95E-10
3 SGTC_1732 st034308 5.33 51.8 µM 5.74E-8 8 4.99E-8
4 SGTC_471 1-acyl-paf 4.62 4.0 µM 2.16E-6 DNA intercalators 19 1.93E-6
5 SGTC_1926 methyl fluorone black 4.46 53.6 µM 4.61E-6 DNA intercalators 47 4.14E-6
6 SGTC_2921 7974240 4.38 10.7 µM 6.45E-6 37 5.81E-6
7 SGTC_1567 st069303 4.27 68.4 µM 1.09E-5 mitochondrial processes 12 9.88E-6
8 SGTC_1910 st062352 4.09 60.4 µM 2.34E-5 32 2.12E-5
9 SGTC_870 0573-2213 3.96 57.6 µM 4.15E-5 ERG2 18 3.79E-5
10 SGTC_145 3737-0113 3.95 38.4 µM 4.35E-5 DNA intercalators 74 3.98E-5
11 SGTC_42 0133-0086 3.89 60.6 µM 5.52E-5 34 5.06E-5
12 SGTC_1313 1220-0047 3.87 237.0 µM 5.94E-5 41 5.45E-5
13 SGTC_461 N-acetylfarnesylcysteine 3.86 136.0 µM 6.26E-5 3 5.74E-5
14 SGTC_2768 sulfasalazine 3.78 50.2 µM 8.66E-5 20 7.96E-5
15 SGTC_2272 7805186 3.68 180.0 µM 1.28E-4 cell wall signaling 24 1.18E-4
16 SGTC_1459 k035-0031 3.67 35.7 µM 1.31E-4 DNA intercalators 30 1.21E-4
17 SGTC_3187 9109394 3.64 49.5 µM 1.48E-4 Golgi 32 1.36E-4
18 SGTC_3033 9090887 3.59 49.5 µM 1.77E-4 fatty acid desaturase (OLE1) 40 1.64E-4
19 SGTC_2858 9025781 3.52 9.0 µM 2.35E-4 sphingolipid biosynthesis & PDR1 123 2.18E-4
20 SGTC_452 diindolylmethane 3.51 8.0 µM 2.43E-4 RNA processing & uracil transport 18 2.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.219 1.38E-37 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.216 1.05E-36 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.215 2.42E-36 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.202 3.71E-32 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.185 5.00E-27 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.175 1.79E-24 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.170 3.69E-23 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.170 4.64E-23 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.170 5.03E-23 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.159 1.68E-20 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.159 2.31E-20 YMR001C-A_p YMR001C-A_p hom Putative protein of unknown function
0.159 2.72E-20 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.158 3.10E-20 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.154 3.57E-19 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.152 1.13E-18 YML018C YML018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication