YPL038W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL038W-A / YPL038W-A

Click on Significant Values for Screen Details ID:SGTC_230|Compound:MPP+|FD-Score:3.11|P-value:2.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.57|P-value:3.58E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.26|P-value:1.38E-4 ID:SGTC_389|Compound:tpck|FD-Score:-2.98|P-value:4.36E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.19|P-value:1.84E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:-3.02|P-value:3.82E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-3.48|P-value:5.23E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:-2.78|P-value:9.64E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.58|P-value:3.38E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:2.84|P-value:7.69E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.78|P-value:5.03E-8 ID:SGTC_716|Compound:1683-5115|FD-Score:3.05|P-value:3.40E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.44|P-value:3.81E-7 ID:SGTC_726|Compound:3448-4391|FD-Score:4.67|P-value:9.92E-8 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.69|P-value:1.93E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.06|P-value:3.15E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-2.91|P-value:5.73E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.96|P-value:4.90E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.88|P-value:7.60E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:2.81|P-value:8.79E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.46|P-value:5.79E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.17|P-value:2.04E-4 ID:SGTC_1716|Compound:st033144|FD-Score:5.35|P-value:1.27E-9 ID:SGTC_1722|Compound:st034304|FD-Score:6.26|P-value:1.51E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-6.44|P-value:3.40E-13 ID:SGTC_1799|Compound:st045822|FD-Score:3.21|P-value:1.74E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-2.92|P-value:5.58E-4 ID:SGTC_1856|Compound:st057054|FD-Score:2.87|P-value:6.88E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-2.95|P-value:4.98E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.61|P-value:2.95E-5 ID:SGTC_1994|Compound:st072947|FD-Score:-3.78|P-value:1.25E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-2.93|P-value:5.41E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-2.78|P-value:9.55E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.82|P-value:1.03E-5 ID:SGTC_2937|Compound:9044753|FD-Score:4.80|P-value:4.53E-8 ID:SGTC_2972|Compound:9093619|FD-Score:2.79|P-value:9.59E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-2.93|P-value:5.46E-4 ID:SGTC_3186|Compound:9110464|FD-Score:2.91|P-value:6.02E-4 ID:SGTC_3218|Compound:9131285|FD-Score:2.94|P-value:5.25E-4 ID:SGTC_3269|Compound:9137823|FD-Score:2.90|P-value:6.10E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.12|P-value:2.60E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.11|P-value:2.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.57|P-value:3.58E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.26|P-value:1.38E-4 ID:SGTC_389|Compound:tpck|FD-Score:-2.98|P-value:4.36E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.19|P-value:1.84E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:-3.02|P-value:3.82E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-3.48|P-value:5.23E-5 ID:SGTC_486|Compound:niguldipine|FD-Score:-2.78|P-value:9.64E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.58|P-value:3.38E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:2.84|P-value:7.69E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.78|P-value:5.03E-8 ID:SGTC_716|Compound:1683-5115|FD-Score:3.05|P-value:3.40E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:2.84|P-value:7.71E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.44|P-value:3.81E-7 ID:SGTC_726|Compound:3448-4391|FD-Score:4.67|P-value:9.92E-8 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.69|P-value:1.93E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:-3.06|P-value:3.15E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-2.91|P-value:5.73E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.96|P-value:4.90E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.88|P-value:7.60E-6 ID:SGTC_1443|Compound:4112-3303|FD-Score:2.81|P-value:8.79E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.46|P-value:5.79E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.17|P-value:2.04E-4 ID:SGTC_1716|Compound:st033144|FD-Score:5.35|P-value:1.27E-9 ID:SGTC_1722|Compound:st034304|FD-Score:6.26|P-value:1.51E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-6.44|P-value:3.40E-13 ID:SGTC_1799|Compound:st045822|FD-Score:3.21|P-value:1.74E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-2.92|P-value:5.58E-4 ID:SGTC_1856|Compound:st057054|FD-Score:2.87|P-value:6.88E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-2.95|P-value:4.98E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.61|P-value:2.95E-5 ID:SGTC_1994|Compound:st072947|FD-Score:-3.78|P-value:1.25E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-2.93|P-value:5.41E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-2.78|P-value:9.55E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.82|P-value:1.03E-5 ID:SGTC_2937|Compound:9044753|FD-Score:4.80|P-value:4.53E-8 ID:SGTC_2972|Compound:9093619|FD-Score:2.79|P-value:9.59E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-2.93|P-value:5.46E-4 ID:SGTC_3186|Compound:9110464|FD-Score:2.91|P-value:6.02E-4 ID:SGTC_3218|Compound:9131285|FD-Score:2.94|P-value:5.25E-4 ID:SGTC_3269|Compound:9137823|FD-Score:2.90|P-value:6.10E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.12|P-value:2.60E-4

Top fitness defect scores for YPL038W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1722 st034304 6.26 3.6 µM 1.51E-12 mitochondrial processes 6 1.91E-10
2 SGTC_1716 st033144 5.35 30.6 µM 1.27E-9 4 4.44E-8
3 SGTC_2937 9044753 4.80 11.3 µM 4.53E-8 60S ribosome export 17 8.05E-7
4 SGTC_662 k832-1615 4.78 104.0 µM 5.03E-8 6 8.75E-7
5 SGTC_726 3448-4391 4.67 34.2 µM 9.92E-8 3 1.52E-6
6 SGTC_720 r052-1644 4.44 49.9 µM 3.81E-7 TSC3-RPN4 21 4.53E-6
7 SGTC_1429 4049-0205 3.88 9.5 µM 7.60E-6 13 5.15E-5
8 SGTC_1002 4049-0206 3.69 172.0 µM 1.93E-5 40 1.10E-4
9 SGTC_1987 st072290 3.61 61.9 µM 2.95E-5 22 1.55E-4
10 SGTC_556 4058-0063 3.58 51.5 µM 3.38E-5 38 1.73E-4
11 SGTC_236 1509-0011 3.57 5.3 µM 3.58E-5 410 1.82E-4
12 SGTC_1570 verbenone 3.46 133.0 µM 5.79E-5 29 2.69E-4
13 SGTC_388 3',4'-dichloroisocoumarin 3.26 16.7 µM 1.38E-4 31 5.48E-4
14 SGTC_1799 st045822 3.21 46.1 µM 1.74E-4 36 6.62E-4
15 SGTC_1635 st007035 3.17 42.4 µM 2.04E-4 274 7.51E-4
16 SGTC_3291 9121177 3.12 71.4 µM 2.60E-4 41 9.18E-4
17 SGTC_230 MPP+ 3.11 141.7 µM 2.62E-4 53 9.22E-4
18 SGTC_716 1683-5115 3.05 658.0 µM 3.40E-4 60 0.00114
19 SGTC_1059 3448-6867 2.96 171.0 µM 4.90E-4 50 0.00154
20 SGTC_3218 9131285 2.94 49.5 µM 5.25E-4 endomembrane recycling 106 0.00163

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 9.76E-34 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.199 2.13E-31 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.191 9.43E-29 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.189 3.15E-28 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.187 1.16E-27 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.184 7.19E-27 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.183 9.45E-27 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.181 3.22E-26 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.180 1.06E-25 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.178 3.05E-25 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.176 8.57E-25 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.175 1.71E-24 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.174 3.43E-24 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.173 4.32E-24 YDR116C MRPL1 hom Mitochondrial ribosomal protein of the large subunit
0.171 1.64E-23 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p