HIPHOP chemogenomics database

YPL044C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W

Zygosity: Heterozygous strain

fixedexpanded
Profile for YPL044C / YPL044C

Click on Significant Values for Screen Details

Top fitness defect scores for YPL044C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_423	5-fluorouracil	9.62	457.0 µM	1.01E-25	exosome	8	3.35E-22	2.32
2	SGTC_610	4215-0184	5.28	155.0 µM	5.66E-9	exosome	16	6.45E-8	0.32
3	SGTC_1074	carmofur	5.27	3.8 µM	5.88E-9	exosome	19	6.66E-8	0.50
4	SGTC_2849	9019321	4.76	13.0 µM	1.34E-7		2	9.65E-7	0.02
5	SGTC_242	5hr heat shock (37°C) + 5-fluorouracil	4.53	4.6 µM	5.05E-7	heat shock/prefoldin	18	3.02E-6	0.03
6	SGTC_65	0798-0905	4.39	35.0 µM	1.06E-6	calcium & mitochondrial duress	6	5.72E-6	0.14
7	SGTC_2568	diosmetin	4.33	100.0 µM	1.48E-6		4	7.59E-6	0.03
8	SGTC_533	1222-0222	4.20	6.7 µM	2.84E-6	PDR1	11	1.33E-5	0.20
9	SGTC_832	4083-0019	4.14	164.0 µM	3.83E-6	translation	25	1.72E-5	0.14
10	SGTC_1077	5-fluorocytosine	3.97	377.0 nM	9.06E-6	exosome	18	3.59E-5	0.24
11	SGTC_2134	5324836	3.74	1.5 µM	2.68E-5		4	9.12E-5	0.50
12	SGTC_1262	0737-0114	3.65	49.6 µM	4.01E-5		5	1.29E-4	0.02
13	SGTC_1013	4112-3890	3.64	241.0 µM	4.29E-5	TSC3-RPN4	9	1.37E-4	0.19
14	SGTC_2927	9011802	3.63	47.9 µM	4.50E-5		10	1.42E-4	0.08
15	SGTC_1698	5-fluorocytosine	3.44	1.1 µM	1.05E-4	exosome	19	2.96E-4	0.10
16	SGTC_2458	5808907	3.43	16.4 µM	1.07E-4		8	3.01E-4	0.06
17	SGTC_432	NS 1619	3.22	61.3 µM	2.61E-4		15	6.49E-4	0.10
18	SGTC_3194	9111903	3.15	49.5 µM	3.42E-4		8	8.17E-4	0.01
19	SGTC_2125	5246583	3.09	200.0 µM	4.35E-4	tubulin folding & SWR complex	12	0.00101	0.03
20	SGTC_2833	9001315	3.07	45.5 µM	4.59E-4	amide catabolism	16	0.00106	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.471	1.58E-184	YGR195W	SKI6	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.397	9.31E-127	YDL111C	RRP42	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.388	4.11E-121	YPL043W	NOP4	het	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.380	9.80E-116	YKL172W	EBP2	het	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.373	1.53E-111	YGR158C	MTR3	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.369	1.31E-108	YPR142C_d	YPR142C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.313	5.74E-77	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.302	1.42E-71	YPR143W	RRP15	het	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.300	7.82E-71	YDR280W	RRP45	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.269	1.28E-56	YGR095C	RRP46	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.233	1.55E-42	YKL021C	MAK11	het	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.223	3.81E-39	YNL232W	CSL4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.217	7.28E-37	YNL061W	NOP2	het	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.212	1.91E-35	YDR060W	MAK21	het	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.184	6.77E-27	YNL002C	RLP7	het	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs