YPL071C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL071C / YPL071C

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-3.67|P-value:9.50E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.67|P-value:6.87E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-7.48|P-value:1.02E-14 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.13|P-value:8.22E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.13|P-value:1.31E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.45|P-value:1.71E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.18|P-value:4.73E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.24|P-value:4.86E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.34|P-value:2.57E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.10|P-value:6.39E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.73|P-value:7.37E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.38|P-value:2.90E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.05|P-value:7.63E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.34|P-value:2.59E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.77|P-value:4.52E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.12|P-value:7.73E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.12|P-value:7.62E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.62|P-value:8.75E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.79|P-value:4.28E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.98|P-value:9.60E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.13|P-value:5.66E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.39|P-value:2.15E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.65|P-value:7.36E-7 ID:SGTC_1726|Compound:st035556|FD-Score:3.34|P-value:2.64E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.07|P-value:1.24E-5 ID:SGTC_2118|Compound:5526350|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.13|P-value:5.76E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.32|P-value:2.83E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.70|P-value:6.15E-5 ID:SGTC_2375|Compound:9072683|FD-Score:4.09|P-value:1.13E-5 ID:SGTC_2377|Compound:9073351|FD-Score:-3.48|P-value:2.01E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.79|P-value:3.53E-7 ID:SGTC_2398|Compound:5228213|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.90|P-value:1.91E-7 ID:SGTC_2464|Compound:5717415|FD-Score:-3.11|P-value:7.85E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.37|P-value:3.02E-6 ID:SGTC_2973|Compound:9094665|FD-Score:3.00|P-value:8.95E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.94|P-value:2.21E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.67|P-value:9.50E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.67|P-value:6.87E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-7.48|P-value:1.02E-14 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.13|P-value:8.22E-8 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.13|P-value:1.31E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.45|P-value:1.71E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.18|P-value:4.73E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.24|P-value:4.86E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.34|P-value:2.57E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.10|P-value:6.39E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.73|P-value:7.37E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.38|P-value:2.90E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.05|P-value:7.63E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.34|P-value:2.59E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.77|P-value:4.52E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.12|P-value:7.73E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.12|P-value:7.62E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.62|P-value:8.75E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.79|P-value:4.28E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.98|P-value:9.60E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.13|P-value:5.66E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.39|P-value:2.15E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.65|P-value:7.36E-7 ID:SGTC_1726|Compound:st035556|FD-Score:3.34|P-value:2.64E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.07|P-value:1.24E-5 ID:SGTC_2118|Compound:5526350|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.13|P-value:5.76E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.32|P-value:2.83E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.70|P-value:6.15E-5 ID:SGTC_2375|Compound:9072683|FD-Score:4.09|P-value:1.13E-5 ID:SGTC_2377|Compound:9073351|FD-Score:-3.48|P-value:2.01E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.79|P-value:3.53E-7 ID:SGTC_2398|Compound:5228213|FD-Score:4.10|P-value:1.05E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.90|P-value:1.91E-7 ID:SGTC_2464|Compound:5717415|FD-Score:-3.11|P-value:7.85E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.37|P-value:3.02E-6 ID:SGTC_2973|Compound:9094665|FD-Score:3.00|P-value:8.95E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.94|P-value:2.21E-5

Top fitness defect scores for YPL071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2406 ethylparaben 4.90 405.7 µM 1.91E-7 17 4.68E-7
2 SGTC_2380 9035439 4.79 200.0 µM 3.53E-7 endomembrane recycling 6 8.35E-7
3 SGTC_1725 st036284 4.65 20.6 µM 7.36E-7 20 1.67E-6
4 SGTC_2968 9090663 4.37 33.4 µM 3.02E-6 21 6.30E-6
5 SGTC_2398 5228213 4.10 48.8 µM 1.05E-5 iron homeostasis 33 2.04E-5
6 SGTC_2375 9072683 4.09 200.0 µM 1.13E-5 mitochondrial processes 16 2.18E-5
7 SGTC_1736 st036774 4.07 51.0 µM 1.24E-5 29 2.38E-5
8 SGTC_3072 9116419 3.94 49.5 µM 2.21E-5 ERG2 16 4.11E-5
9 SGTC_1288 0973-0013 3.79 65.5 µM 4.28E-5 18 7.66E-5
10 SGTC_1189 1431-2119 3.77 7.3 µM 4.52E-5 34 8.05E-5
11 SGTC_2175 5807670 3.70 165.3 µM 6.15E-5 25 1.08E-4
12 SGTC_133 0724-0033 3.67 378.9 µM 6.87E-5 39 1.20E-4
13 SGTC_1270 0831-1170 3.62 17.3 µM 8.75E-5 17 1.50E-4
14 SGTC_1520 flindersine 3.56 88.0 µM 1.08E-4 41 1.83E-4
15 SGTC_662 k832-1615 3.48 104.0 µM 1.49E-4 38 2.47E-4
16 SGTC_423 5-fluorouracil 3.45 457.0 µM 1.71E-4 exosome 39 2.82E-4
17 SGTC_2794 7785382 3.39 27.3 µM 2.12E-4 58 3.46E-4
18 SGTC_1587 estradiol valerate 3.39 56.1 µM 2.15E-4 25 3.50E-4
19 SGTC_654 1124-0271 3.34 80.9 µM 2.57E-4 50 4.13E-4
20 SGTC_1031 k035-0009 3.34 16.0 µM 2.59E-4 57 4.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.18E-13 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.104 1.61E-9 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.104 1.70E-9 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.094 5.47E-8 YNR009W NRM1 hom Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
0.092 8.19E-8 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.090 1.79E-7 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.89E-7 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.088 2.87E-7 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.084 1.19E-6 YLR267W_p BOP2_p hom Protein of unknown function
0.083 1.38E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.083 1.35E-6 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.083 1.45E-6 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.082 2.17E-6 YPL200W CSM4 hom Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
0.082 2.21E-6 YHL022C SPO11 hom Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
0.080 3.06E-6 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein