YPL078C / ATP4

Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL078C / ATP4

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.49|P-value:3.28E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.39|P-value:8.14E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.65|P-value:2.95E-6 ID:SGTC_84|Compound:0443-0269|FD-Score:3.57|P-value:2.52E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.71|P-value:1.50E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.27|P-value:7.07E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.52|P-value:2.99E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.82|P-value:9.94E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.48|P-value:4.09E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.01|P-value:5.56E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:3.58|P-value:2.40E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.50|P-value:2.29E-51 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.47|P-value:3.53E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.40|P-value:3.17E-24 ID:SGTC_314|Compound:1671-0008|FD-Score:3.98|P-value:5.37E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.25|P-value:9.12E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.45|P-value:3.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.62|P-value:2.56E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.83|P-value:9.66E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.19|P-value:9.14E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.75|P-value:1.59E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.31|P-value:1.34E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.47|P-value:4.29E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.27|P-value:7.06E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.29|P-value:6.72E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.40|P-value:4.60E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.29|P-value:8.04E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.42|P-value:4.32E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.29|P-value:6.64E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.80|P-value:1.07E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.58|P-value:4.05E-6 ID:SGTC_1732|Compound:st034308|FD-Score:3.30|P-value:6.35E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-3.44|P-value:4.72E-4 ID:SGTC_1891|Compound:st059073|FD-Score:6.42|P-value:2.25E-10 ID:SGTC_1980|Compound:st071811|FD-Score:3.48|P-value:3.40E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.35|P-value:5.42E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.36|P-value:5.19E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.75|P-value:1.29E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.13|P-value:3.62E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.32|P-value:7.17E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.71|P-value:1.48E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.16|P-value:2.55E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.74|P-value:4.04E-14 ID:SGTC_2585|Compound:alliin|FD-Score:3.60|P-value:2.23E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.86|P-value:8.35E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.91|P-value:1.17E-6 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.18|P-value:9.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.41|P-value:4.44E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.40|P-value:5.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.26|P-value:8.89E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.47|P-value:6.66E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:3.49|P-value:3.28E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.39|P-value:8.14E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:3.19|P-value:9.27E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.65|P-value:2.95E-6 ID:SGTC_84|Compound:0443-0269|FD-Score:3.57|P-value:2.52E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.71|P-value:1.50E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.27|P-value:7.07E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.52|P-value:2.99E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.82|P-value:9.94E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.48|P-value:4.09E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.01|P-value:5.56E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:3.58|P-value:2.40E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.50|P-value:2.29E-51 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.47|P-value:3.53E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.40|P-value:3.17E-24 ID:SGTC_314|Compound:1671-0008|FD-Score:3.98|P-value:5.37E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.25|P-value:9.12E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.45|P-value:3.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.62|P-value:2.56E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.83|P-value:9.66E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.19|P-value:9.14E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.75|P-value:1.59E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.31|P-value:1.34E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.47|P-value:4.29E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.27|P-value:7.06E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.29|P-value:6.72E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.40|P-value:4.60E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.29|P-value:8.04E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.42|P-value:4.32E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.29|P-value:6.64E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.80|P-value:1.07E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.58|P-value:4.05E-6 ID:SGTC_1732|Compound:st034308|FD-Score:3.30|P-value:6.35E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-3.44|P-value:4.72E-4 ID:SGTC_1891|Compound:st059073|FD-Score:6.42|P-value:2.25E-10 ID:SGTC_1980|Compound:st071811|FD-Score:3.48|P-value:3.40E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.35|P-value:5.42E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.36|P-value:5.19E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.75|P-value:1.29E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.13|P-value:3.62E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.32|P-value:7.17E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.71|P-value:1.48E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:5.16|P-value:2.55E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.74|P-value:4.04E-14 ID:SGTC_2585|Compound:alliin|FD-Score:3.60|P-value:2.23E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.86|P-value:8.35E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.91|P-value:1.17E-6 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.18|P-value:9.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.41|P-value:4.44E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.40|P-value:5.52E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.26|P-value:8.89E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.47|P-value:6.66E-6

Top fitness defect scores for YPL078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.50 5.3 µM 2.29E-51 93 1.57E-54
2 SGTC_310 1273-0058 10.40 1.1 µM 3.17E-24 mitochondrial stress 38 1.28E-25
3 SGTC_1891 st059073 6.42 26.2 µM 2.25E-10 TSC3-RPN4 4 6.95E-11
4 SGTC_63 0099-0242 5.39 26.7 µM 8.14E-8 mitochondrial stress 43 3.61E-8
5 SGTC_2501 sodium tetradecyl sulfate 5.16 13.4 µM 2.55E-7 15 1.21E-7
6 SGTC_168 3970-0862 5.01 530.5 µM 5.56E-7 69 2.77E-7
7 SGTC_70 0141-0289 4.65 43.3 µM 2.95E-6 mitochondrial stress 129 1.62E-6
8 SGTC_1627 st003713 4.58 25.6 µM 4.05E-6 calcium & mitochondrial duress 52 2.27E-6
9 SGTC_3207 9114163 4.47 49.5 µM 6.66E-6 22 3.85E-6
10 SGTC_908 3448-7491 4.31 47.7 µM 1.34E-5 mitochondrial stress 101 8.09E-6
11 SGTC_314 1671-0008 3.98 2.7 µM 5.37E-5 52 3.51E-5
12 SGTC_2589 lobaric acid 3.86 100.0 µM 8.35E-5 26 5.59E-5
13 SGTC_545 4218-0007 3.83 221.0 µM 9.66E-5 31 6.52E-5
14 SGTC_119 0121-0043 3.82 24.8 µM 9.94E-5 mitochondrial stress 123 6.72E-5
15 SGTC_1521 st012942 3.80 49.4 µM 1.07E-4 35 7.25E-5
16 SGTC_2250 alverine citrate 3.75 130.0 µM 1.29E-4 173 8.89E-5
17 SGTC_2413 inermin 3.71 26.1 µM 1.48E-4 64 1.02E-4
18 SGTC_87 0100-0052 3.71 35.5 µM 1.50E-4 130 1.04E-4
19 SGTC_988 1497-1057 3.66 103.0 µM 1.77E-4 16 1.24E-4
20 SGTC_2585 alliin 3.60 100.0 µM 2.23E-4 41 1.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.496 4.42E-208 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.492 1.56E-204 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.470 1.12E-183 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.461 1.71E-176 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.457 3.48E-173 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.456 9.80E-172 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.454 2.49E-170 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.450 2.39E-167 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.443 1.43E-160 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.441 1.33E-159 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.440 6.39E-159 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.439 2.04E-157 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.434 5.19E-154 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.432 1.11E-152 YDR377W ATP17 hom Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.431 5.33E-152 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit