YPL092W / SSU1

Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL092W / SSU1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.38|P-value:5.21E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.96|P-value:2.80E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.08|P-value:9.76E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.38|P-value:3.42E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.34|P-value:4.00E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.34|P-value:6.13E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.41|P-value:3.09E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.22|P-value:8.94E-6 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.73|P-value:8.94E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.55|P-value:1.51E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.73|P-value:7.35E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.46|P-value:2.51E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.67|P-value:9.31E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.02|P-value:2.62E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.09|P-value:8.38E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-6.76|P-value:3.38E-12 ID:SGTC_2394|Compound:5221648|FD-Score:5.81|P-value:2.43E-9 ID:SGTC_2395|Compound:5646831|FD-Score:7.35|P-value:6.15E-14 ID:SGTC_2400|Compound:5203494|FD-Score:-3.82|P-value:5.17E-5 ID:SGTC_2404|Compound:5161160|FD-Score:4.70|P-value:1.12E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.41|P-value:3.01E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.01|P-value:2.77E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.47|P-value:2.04E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.71|P-value:8.14E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.71|P-value:9.58E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.21|P-value:6.29E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.22|P-value:5.26E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.33|P-value:4.15E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.38|P-value:5.21E-6 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.96|P-value:2.80E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.08|P-value:9.76E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.38|P-value:3.42E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:3.34|P-value:4.00E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.34|P-value:6.13E-6 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.41|P-value:3.09E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.22|P-value:8.94E-6 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.73|P-value:8.94E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.55|P-value:1.51E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.73|P-value:7.35E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.46|P-value:2.51E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.67|P-value:9.31E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.02|P-value:2.62E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.09|P-value:8.38E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-6.76|P-value:3.38E-12 ID:SGTC_2394|Compound:5221648|FD-Score:5.81|P-value:2.43E-9 ID:SGTC_2395|Compound:5646831|FD-Score:7.35|P-value:6.15E-14 ID:SGTC_2400|Compound:5203494|FD-Score:-3.82|P-value:5.17E-5 ID:SGTC_2404|Compound:5161160|FD-Score:4.70|P-value:1.12E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.41|P-value:3.01E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.01|P-value:2.77E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.47|P-value:2.04E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.71|P-value:8.14E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.71|P-value:9.58E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.21|P-value:6.29E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.22|P-value:5.26E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.33|P-value:4.15E-4

Top fitness defect scores for YPL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2395 5646831 7.35 180.2 µM 6.15E-14 2 9.89E-14
2 SGTC_2394 5221648 5.81 200.0 µM 2.43E-9 6 3.20E-9
3 SGTC_2404 5161160 4.70 200.0 µM 1.12E-6 9 1.31E-6
4 SGTC_6 0844-0013 4.38 19.8 µM 5.21E-6 55 5.96E-6
5 SGTC_1080 nisoldipine 4.34 24.4 µM 6.13E-6 TSC3-RPN4 17 6.99E-6
6 SGTC_1859 st055998 4.02 20.0 µM 2.62E-5 21 2.91E-5
7 SGTC_2762 leflunomide 4.01 42.1 µM 2.77E-5 25 3.07E-5
8 SGTC_1151 3909-8316 3.73 15.3 µM 8.94E-5 21 9.74E-5
9 SGTC_2930 9013230 3.71 14.9 µM 9.58E-5 heme biosynthesis & mitochondrial translocase 49 1.04E-4
10 SGTC_1853 st056710 3.46 91.2 µM 2.51E-4 amide catabolism 46 2.69E-4
11 SGTC_2413 inermin 3.41 26.1 µM 3.01E-4 78 3.21E-4
12 SGTC_1085 doxorubicin 3.41 7.7 µM 3.09E-4 anthracycline transcription coupled DNA repair 36 3.30E-4
13 SGTC_643 k048-0106 3.38 28.4 µM 3.42E-4 RSC & ERG11 20 3.65E-4
14 SGTC_693 4161-2696 3.34 114.0 µM 4.00E-4 23 4.25E-4
15 SGTC_3352 9151559 3.33 45.6 µM 4.15E-4 26 4.41E-4
16 SGTC_2947 9072639 3.21 7.7 µM 6.29E-4 tubulin folding & SWR complex 83 6.64E-4
17 SGTC_464 bw-b 70c 3.08 158.0 µM 9.76E-4 66 0.00102
18 SGTC_1033 k072-0102 3.02 21.3 µM 0.00122 60S ribosome export 65 0.00128
19 SGTC_621 3584-0052 2.97 32.1 µM 0.00145 64 0.00151
20 SGTC_2767 sibutramine 2.95 71.5 µM 0.00151 64 0.00157

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.292 4.34E-67 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.212 2.07E-35 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.190 1.41E-28 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.182 2.00E-26 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.180 8.96E-26 YML038C YMD8 hom Putative nucleotide sugar transporter, has similarity to Vrg4p
0.160 1.66E-20 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.157 5.26E-20 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.142 1.21E-16 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.136 3.40E-15 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.132 1.55E-14 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.130 4.95E-14 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.129 5.56E-14 YKR011C YKR011C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
0.129 8.12E-14 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.128 9.18E-14 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.128 1.08E-13 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck