YPL099C / AIM43

Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL099C / AIM43

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.54|P-value:7.26E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.02|P-value:5.54E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.06|P-value:4.85E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.65|P-value:4.37E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.00|P-value:6.06E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.01|P-value:6.13E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.09|P-value:4.49E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.27|P-value:2.25E-6 ID:SGTC_1611|Compound:st001856|FD-Score:-3.14|P-value:3.50E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.14|P-value:3.81E-4 ID:SGTC_1793|Compound:st048256|FD-Score:4.55|P-value:5.15E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.07|P-value:4.95E-4 ID:SGTC_1881|Compound:5652484|FD-Score:2.93|P-value:8.27E-4 ID:SGTC_2023|Compound:5144124|FD-Score:2.89|P-value:9.60E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.96|P-value:1.04E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-2.92|P-value:8.18E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.85|P-value:1.63E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-4.87|P-value:7.54E-8 ID:SGTC_2305|Compound:7443522|FD-Score:3.83|P-value:1.95E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.59|P-value:5.83E-5 ID:SGTC_2326|Compound:6164455|FD-Score:4.16|P-value:3.95E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.64|P-value:4.41E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.75|P-value:2.67E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.61|P-value:5.03E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.48|P-value:9.55E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-3.21|P-value:2.69E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.91|P-value:1.35E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.68|P-value:2.49E-7 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.58|P-value:6.06E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.12|P-value:4.73E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:2.92|P-value:8.51E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.02|P-value:5.93E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.55|P-value:6.97E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-4.07|P-value:5.88E-6 ID:SGTC_2832|Compound:7992762|FD-Score:4.10|P-value:5.36E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.07|P-value:4.86E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.04|P-value:6.73E-6 ID:SGTC_2899|Compound:9053889|FD-Score:-2.94|P-value:7.50E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.53|P-value:5.21E-7 ID:SGTC_2921|Compound:7974240|FD-Score:5.50|P-value:1.71E-9 ID:SGTC_2922|Compound:7999257|FD-Score:-3.03|P-value:5.43E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-7.57|P-value:1.76E-16 ID:SGTC_2928|Compound:9011484|FD-Score:-4.22|P-value:2.77E-6 ID:SGTC_2949|Compound:9072542|FD-Score:6.29|P-value:6.92E-12 ID:SGTC_2952|Compound:9073731|FD-Score:-3.26|P-value:2.22E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.48|P-value:1.93E-9 ID:SGTC_2990|Compound:9074105|FD-Score:2.88|P-value:9.90E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.05|P-value:5.25E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.52|P-value:7.73E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.59|P-value:5.74E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.22|P-value:2.58E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.88|P-value:1.56E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:3.54|P-value:7.26E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.02|P-value:5.54E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.06|P-value:4.85E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.65|P-value:4.37E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.00|P-value:6.06E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.01|P-value:6.13E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.09|P-value:4.49E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.27|P-value:2.25E-6 ID:SGTC_1611|Compound:st001856|FD-Score:-3.14|P-value:3.50E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.14|P-value:3.81E-4 ID:SGTC_1793|Compound:st048256|FD-Score:4.55|P-value:5.15E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.07|P-value:4.95E-4 ID:SGTC_1881|Compound:5652484|FD-Score:2.93|P-value:8.27E-4 ID:SGTC_2023|Compound:5144124|FD-Score:2.89|P-value:9.60E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.96|P-value:1.04E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-2.92|P-value:8.18E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.85|P-value:1.63E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-4.87|P-value:7.54E-8 ID:SGTC_2305|Compound:7443522|FD-Score:3.83|P-value:1.95E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.59|P-value:5.83E-5 ID:SGTC_2326|Compound:6164455|FD-Score:4.16|P-value:3.95E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.64|P-value:4.41E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.75|P-value:2.67E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.61|P-value:5.03E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.48|P-value:9.55E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-3.21|P-value:2.69E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.91|P-value:1.35E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.68|P-value:2.49E-7 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.58|P-value:6.06E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.12|P-value:4.73E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:2.92|P-value:8.51E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.02|P-value:5.93E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.55|P-value:6.97E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-4.07|P-value:5.88E-6 ID:SGTC_2832|Compound:7992762|FD-Score:4.10|P-value:5.36E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.07|P-value:4.86E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.04|P-value:6.73E-6 ID:SGTC_2899|Compound:9053889|FD-Score:-2.94|P-value:7.50E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-4.53|P-value:5.21E-7 ID:SGTC_2921|Compound:7974240|FD-Score:5.50|P-value:1.71E-9 ID:SGTC_2922|Compound:7999257|FD-Score:-3.03|P-value:5.43E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-7.57|P-value:1.76E-16 ID:SGTC_2928|Compound:9011484|FD-Score:-4.22|P-value:2.77E-6 ID:SGTC_2949|Compound:9072542|FD-Score:6.29|P-value:6.92E-12 ID:SGTC_2952|Compound:9073731|FD-Score:-3.26|P-value:2.22E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.48|P-value:1.93E-9 ID:SGTC_2990|Compound:9074105|FD-Score:2.88|P-value:9.90E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.05|P-value:5.25E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.52|P-value:7.73E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.59|P-value:5.74E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.22|P-value:2.58E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.88|P-value:1.56E-5

Top fitness defect scores for YPL099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2949 9072542 6.29 2.2 µM 6.92E-12 TSC3-RPN4 4 1.57E-10
2 SGTC_2921 7974240 5.50 10.7 µM 1.71E-9 19 1.88E-8
3 SGTC_2988 9073640 5.48 71.4 µM 1.93E-9 6 2.09E-8
4 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 4.68 19.9 µM 2.49E-7 redox potentiating 5 1.43E-6
5 SGTC_1793 st048256 4.55 72.2 µM 5.15E-7 1 2.69E-6
6 SGTC_1464 k208-0027 4.27 110.0 µM 2.25E-6 19 9.72E-6
7 SGTC_2326 6164455 4.16 177.6 µM 3.95E-6 mitochondrial processes 17 1.59E-5
8 SGTC_2603 homopterocarpin 4.12 100.0 µM 4.73E-6 31 1.85E-5
9 SGTC_2832 7992762 4.10 52.0 µM 5.36E-6 24 2.07E-5
10 SGTC_2049 5262831 3.96 67.2 µM 1.04E-5 25 3.70E-5
11 SGTC_2536 dehydroabietamide 3.91 32.0 µM 1.35E-5 35 4.61E-5
12 SGTC_3352 9151559 3.88 45.6 µM 1.56E-5 13 5.26E-5
13 SGTC_2305 7443522 3.83 69.2 µM 1.95E-5 17 6.36E-5
14 SGTC_551 k048-0028 3.65 34.9 µM 4.37E-5 27 1.29E-4
15 SGTC_3343 9148379 3.59 19.0 µM 5.74E-5 10 1.63E-4
16 SGTC_2318 6029776 3.59 164.0 µM 5.83E-5 41 1.66E-4
17 SGTC_2561 acetosyringone 3.58 100.0 µM 6.06E-5 39 1.71E-4
18 SGTC_2817 7995342 3.55 71.4 µM 6.97E-5 36 1.94E-4
19 SGTC_65 0798-0905 3.54 35.0 µM 7.26E-5 calcium & mitochondrial duress 112 2.01E-4
20 SGTC_3207 9114163 3.52 49.5 µM 7.73E-5 46 2.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.78E-20 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.124 4.52E-13 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.105 1.00E-9 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.09E-9 YCL043C PDI1 het Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
0.103 2.14E-9 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.103 2.45E-9 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.101 3.88E-9 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.096 2.34E-8 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.094 4.19E-8 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.094 4.60E-8 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.094 5.40E-8 YBL077W_d YBL077W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
0.092 9.45E-8 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.091 1.48E-7 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.088 3.65E-7 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.087 4.11E-7 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway