YPL112C / PEX25

Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL112C / PEX25

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.02|P-value:9.99E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.09|P-value:7.86E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.48|P-value:1.47E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.21|P-value:6.20E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.09|P-value:6.67E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.30|P-value:3.67E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.32|P-value:2.81E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.20|P-value:5.28E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.24|P-value:5.50E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.23|P-value:7.16E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.89|P-value:3.41E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.20|P-value:4.43E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.77|P-value:4.58E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.58|P-value:1.20E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.11|P-value:1.25E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.76|P-value:5.84E-5 ID:SGTC_2265|Compound:7929201|FD-Score:-3.37|P-value:2.27E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.67|P-value:8.10E-7 ID:SGTC_2447|Compound:5741742|FD-Score:3.66|P-value:8.87E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.11|P-value:1.27E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.44|P-value:2.14E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.25|P-value:4.46E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.07|P-value:8.44E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.29|P-value:3.15E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.48|P-value:2.20E-6 ID:SGTC_3009|Compound:9080819|FD-Score:-3.27|P-value:3.42E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.02|P-value:9.99E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.09|P-value:7.86E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.48|P-value:1.47E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.21|P-value:6.20E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.09|P-value:6.67E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.30|P-value:3.67E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.32|P-value:2.81E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.20|P-value:5.28E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.24|P-value:5.50E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.23|P-value:7.16E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.89|P-value:3.41E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.20|P-value:4.43E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-3.77|P-value:4.58E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.58|P-value:1.20E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.11|P-value:1.25E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.76|P-value:5.84E-5 ID:SGTC_2265|Compound:7929201|FD-Score:-3.37|P-value:2.27E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.67|P-value:8.10E-7 ID:SGTC_2447|Compound:5741742|FD-Score:3.66|P-value:8.87E-5 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.11|P-value:1.27E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:3.22|P-value:4.90E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.44|P-value:2.14E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.25|P-value:4.46E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.07|P-value:8.44E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-3.29|P-value:3.15E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.48|P-value:2.20E-6 ID:SGTC_3009|Compound:9080819|FD-Score:-3.27|P-value:3.42E-4

Top fitness defect scores for YPL112C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2413 inermin 4.67 26.1 µM 8.10E-7 35 1.48E-6
2 SGTC_3003 9075612 4.48 71.4 µM 2.20E-6 13 3.80E-6
3 SGTC_1030 k029-0042 4.23 36.7 µM 7.16E-6 TSC3-RPN4 19 1.16E-5
4 SGTC_1561 5-methoxyflavone 4.11 52.9 µM 1.25E-5 6 1.97E-5
5 SGTC_2546 rhodinyl acetate 4.11 100.0 µM 1.27E-5 11 2.00E-5
6 SGTC_1038 k292-0204 3.89 154.0 µM 3.41E-5 18 5.11E-5
7 SGTC_2064 5220758 3.76 200.0 µM 5.84E-5 40 8.51E-5
8 SGTC_2447 5741742 3.66 33.8 µM 8.87E-5 30 1.26E-4
9 SGTC_1305 1181-0477 3.59 144.0 µM 1.17E-4 22 1.65E-4
10 SGTC_1554 st069299 3.58 38.7 µM 1.20E-4 33 1.69E-4
11 SGTC_1043 0916-0009 3.55 19.3 µM 1.38E-4 35 1.93E-4
12 SGTC_2606 farnesol 3.44 9.8 µM 2.14E-4 38 2.92E-4
13 SGTC_831 k061-1017 3.30 217.0 µM 3.67E-4 translation 104 4.86E-4
14 SGTC_2663 amphotericin b 3.25 100.0 µM 4.46E-4 25 5.86E-4
15 SGTC_2586 curcumin 3.22 80.0 µM 4.90E-4 iron homeostasis 92 6.40E-4
16 SGTC_919 tnp00227 3.20 403.6 nM 5.28E-4 RNA pol III & RNase P/MRP 77 6.88E-4
17 SGTC_168 3970-0862 3.15 530.5 µM 6.38E-4 202 8.23E-4
18 SGTC_636 0kpi-0074 3.09 126.0 µM 7.86E-4 46 0.00100
19 SGTC_2721 ifenprodil 3.07 61.4 µM 8.44E-4 plasma membrane duress 56 0.00107
20 SGTC_49 0717-0965 3.02 32.1 µM 9.99E-4 60S ribosome export 59 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 3.32E-28 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.147 9.76E-18 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.134 7.08E-15 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.132 1.70E-14 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.111 1.10E-10 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.111 1.21E-10 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.108 3.35E-10 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.108 3.83E-10 YNL316C PHA2 hom Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
0.104 1.59E-9 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.103 2.38E-9 YMR001C CDC5 het Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
0.103 2.29E-9 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.099 8.06E-9 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.098 1.52E-8 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.094 4.75E-8 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.090 1.75E-7 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels