YPL116W / HOS3

Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL116W / HOS3

Click on Significant Values for Screen Details ID:SGTC_157|Compound:1348-1695|FD-Score:-2.90|P-value:6.15E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.86|P-value:7.41E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.23|P-value:1.61E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:2.81|P-value:8.75E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.14|P-value:2.43E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:2.97|P-value:4.82E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.52|P-value:4.49E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.50|P-value:4.94E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.40|P-value:4.79E-7 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.79|P-value:9.35E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.34|P-value:1.01E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.91|P-value:6.08E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.64|P-value:2.42E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.13|P-value:2.45E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:2.85|P-value:7.68E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.97|P-value:4.51E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.87|P-value:6.81E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.87|P-value:8.49E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.35|P-value:9.57E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.60|P-value:2.91E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.81|P-value:9.05E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.07|P-value:3.24E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.11|P-value:2.55E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.85|P-value:9.24E-6 ID:SGTC_2282|Compound:7944268|FD-Score:2.96|P-value:4.99E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.68|P-value:2.12E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.10|P-value:2.84E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.20|P-value:1.75E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.27|P-value:1.40E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.85|P-value:7.52E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.33|P-value:1.05E-4 ID:SGTC_2918|Compound:7977171|FD-Score:2.86|P-value:7.30E-4 ID:SGTC_2919|Compound:7978188|FD-Score:5.91|P-value:2.34E-11 ID:SGTC_2928|Compound:9011484|FD-Score:3.39|P-value:8.11E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-2.90|P-value:6.15E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.86|P-value:7.41E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.23|P-value:1.61E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:2.81|P-value:8.75E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.14|P-value:2.43E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:2.97|P-value:4.82E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.52|P-value:4.49E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.50|P-value:4.94E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.40|P-value:4.79E-7 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.79|P-value:9.35E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.34|P-value:1.01E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.91|P-value:6.08E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.64|P-value:2.42E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.13|P-value:2.45E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:2.85|P-value:7.68E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.97|P-value:4.51E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.87|P-value:6.81E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.87|P-value:8.49E-6 ID:SGTC_1760|Compound:st045453|FD-Score:3.35|P-value:9.57E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.60|P-value:2.91E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.81|P-value:9.05E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.07|P-value:3.24E-4 ID:SGTC_2072|Compound:5231554|FD-Score:-3.11|P-value:2.55E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.85|P-value:9.24E-6 ID:SGTC_2282|Compound:7944268|FD-Score:2.96|P-value:4.99E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.68|P-value:2.12E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.10|P-value:2.84E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.20|P-value:1.75E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.27|P-value:1.40E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.85|P-value:7.52E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.33|P-value:1.05E-4 ID:SGTC_2918|Compound:7977171|FD-Score:2.86|P-value:7.30E-4 ID:SGTC_2919|Compound:7978188|FD-Score:5.91|P-value:2.34E-11 ID:SGTC_2928|Compound:9011484|FD-Score:3.39|P-value:8.11E-5

Top fitness defect scores for YPL116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2919 7978188 5.91 46.4 µM 2.34E-11 3 1.69E-9
2 SGTC_874 0599-0792 4.40 117.0 µM 4.79E-7 17 5.32E-6
3 SGTC_1758 st042942 3.87 75.2 µM 8.49E-6 25 5.53E-5
4 SGTC_2097 5376186 3.85 200.0 µM 9.24E-6 23 5.93E-5
5 SGTC_2311 7694451 3.68 200.0 µM 2.12E-5 26 1.17E-4
6 SGTC_739 1486-1183 3.52 203.0 µM 4.49E-5 27 2.15E-4
7 SGTC_766 1391-0721 3.50 126.0 µM 4.94E-5 31 2.33E-4
8 SGTC_2928 9011484 3.39 9.8 µM 8.11E-5 heme biosynthesis & mitochondrial translocase 54 3.49E-4
9 SGTC_1760 st045453 3.35 10.4 µM 9.57E-5 NEO1-PIK1 171 3.99E-4
10 SGTC_916 4466-0038 3.34 42.0 nM 1.01E-4 cell wall 106 4.17E-4
11 SGTC_2829 7992743 3.33 58.4 µM 1.05E-4 63 4.30E-4
12 SGTC_2754 granisetron 3.30 64.0 µM 1.19E-4 60 4.78E-4
13 SGTC_2756 carbadox 3.27 75.1 µM 1.40E-4 89 5.44E-4
14 SGTC_326 k292-0812 3.23 17.5 µM 1.61E-4 19 6.11E-4
15 SGTC_408 cantharidin 3.14 100.0 µM 2.43E-4 cell wall signaling 52 8.56E-4
16 SGTC_1229 0139-0193 3.13 12.2 µM 2.45E-4 RSC complex & mRNA processing 42 8.62E-4
17 SGTC_2625 euphol 3.10 100.0 µM 2.84E-4 74 9.71E-4
18 SGTC_1948 st076329 3.07 66.6 µM 3.24E-4 67 0.00108
19 SGTC_738 1315-0003 2.97 72.4 µM 4.82E-4 62 0.00150
20 SGTC_2282 7944268 2.96 200.0 µM 4.99E-4 RPP1 & pyrimidine depletion 91 0.00154

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.81E-18 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.134 7.72E-15 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.130 3.89E-14 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.126 2.98E-13 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.122 1.28E-12 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.119 3.78E-12 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.117 1.27E-11 YIL085C KTR7 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication
0.114 3.82E-11 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.113 5.47E-11 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.12E-10 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.108 3.29E-10 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.102 2.75E-9 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.102 3.46E-9 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.101 4.27E-9 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.099 1.02E-8 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.