YPL119C-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL119C-A / YPL119C-A

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.57|P-value:1.39E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:3.39|P-value:2.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.07|P-value:2.38E-10 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.06|P-value:8.70E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.12|P-value:7.07E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.44|P-value:2.11E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.08|P-value:8.23E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.78|P-value:4.98E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.26|P-value:4.22E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.07|P-value:8.40E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-4.27|P-value:5.42E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.19|P-value:5.39E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.27|P-value:4.05E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.87|P-value:2.70E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.91|P-value:3.14E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.83|P-value:4.42E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.43|P-value:2.09E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.32|P-value:3.11E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.66|P-value:8.25E-5 ID:SGTC_1907|Compound:st060210|FD-Score:4.04|P-value:1.72E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.86|P-value:3.55E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.83|P-value:4.38E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.16|P-value:5.62E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.52|P-value:1.56E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.38|P-value:2.66E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.83|P-value:3.73E-7 ID:SGTC_2288|Compound:7946289|FD-Score:4.57|P-value:1.42E-6 ID:SGTC_2365|Compound:9042475|FD-Score:-3.12|P-value:6.52E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.05|P-value:8.28E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.08|P-value:8.15E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.16|P-value:5.64E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.12|P-value:6.61E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.03|P-value:9.52E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.15|P-value:5.95E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.68|P-value:7.60E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:4.57|P-value:1.39E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:3.39|P-value:2.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.07|P-value:2.38E-10 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.06|P-value:8.70E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.12|P-value:7.07E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.44|P-value:2.11E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.08|P-value:8.23E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.78|P-value:4.98E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.26|P-value:4.22E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.07|P-value:8.40E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-4.27|P-value:5.42E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.19|P-value:5.39E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.27|P-value:4.05E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.87|P-value:2.70E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.91|P-value:3.14E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.83|P-value:4.42E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.43|P-value:2.09E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.32|P-value:3.11E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.66|P-value:8.25E-5 ID:SGTC_1907|Compound:st060210|FD-Score:4.04|P-value:1.72E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.86|P-value:3.55E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.83|P-value:4.38E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.16|P-value:5.62E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.52|P-value:1.56E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.38|P-value:2.66E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.83|P-value:3.73E-7 ID:SGTC_2288|Compound:7946289|FD-Score:4.57|P-value:1.42E-6 ID:SGTC_2365|Compound:9042475|FD-Score:-3.12|P-value:6.52E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.05|P-value:8.28E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.08|P-value:8.15E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.16|P-value:5.64E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.12|P-value:6.61E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.03|P-value:9.52E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.15|P-value:5.95E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.68|P-value:7.60E-5

Top fitness defect scores for YPL119C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 6.07 5.3 µM 2.38E-10 290 6.20E-10
2 SGTC_2127 5253358 4.83 187.9 µM 3.73E-7 8 6.82E-7
3 SGTC_65 0798-0905 4.57 35.0 µM 1.39E-6 calcium & mitochondrial duress 62 2.39E-6
4 SGTC_2288 7946289 4.57 167.3 µM 1.42E-6 14 2.44E-6
5 SGTC_1907 st060210 4.04 83.7 µM 1.72E-5 19 2.62E-5
6 SGTC_1456 k015-0012 3.91 13.0 µM 3.14E-5 33 4.65E-5
7 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.83 70.1 µM 4.38E-5 28 6.39E-5
8 SGTC_1650 st011916 3.83 45.8 µM 4.42E-5 16 6.45E-5
9 SGTC_2032 5185112 3.52 26.0 µM 1.56E-4 16 2.15E-4
10 SGTC_426 0988-0037 3.44 14.6 µM 2.11E-4 ERAD & cell cycle 54 2.86E-4
11 SGTC_1736 st036774 3.42 51.0 µM 2.34E-4 57 3.16E-4
12 SGTC_75 0159-0059 3.39 199.0 µM 2.61E-4 fatty acid desaturase (OLE1) 33 3.50E-4
13 SGTC_2125 5246583 3.38 200.0 µM 2.66E-4 tubulin folding & SWR complex 68 3.57E-4
14 SGTC_1260 0700-1617 3.27 7.8 µM 4.05E-4 calcium & mitochondrial duress 59 5.33E-4
15 SGTC_968 1309-0633 3.26 340.0 µM 4.22E-4 30 5.55E-4
16 SGTC_1128 3448-9350 3.19 235.0 µM 5.39E-4 53 7.01E-4
17 SGTC_355 1311-2252 3.12 105.0 µM 7.07E-4 59 9.08E-4
18 SGTC_2483 5729050 3.08 27.2 µM 8.15E-4 63 0.00104
19 SGTC_635 k038-0028 3.08 24.7 µM 8.23E-4 ubiquinone biosynthesis & proteasome 92 0.00105
20 SGTC_1015 4130-4525 3.07 82.0 µM 8.40E-4 60S ribosome export 62 0.00107

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 2.24E-38 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.220 4.99E-38 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.217 4.18E-37 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.211 5.42E-35 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.206 1.36E-33 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.203 1.79E-32 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.202 4.41E-32 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.197 9.28E-31 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.192 3.04E-29 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.188 6.41E-28 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.184 8.09E-27 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.183 9.69E-27 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.183 1.46E-26 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.181 5.90E-26 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.178 2.19E-25 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes