YPL133C / RDS2

Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL133C / RDS2

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-2.84|P-value:7.94E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.13|P-value:2.11E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.64|P-value:2.52E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:5.62|P-value:1.37E-10 ID:SGTC_443|Compound:clozapine|FD-Score:2.99|P-value:3.78E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.90|P-value:6.84E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:4.31|P-value:6.54E-7 ID:SGTC_500|Compound:h-89|FD-Score:2.96|P-value:4.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.18|P-value:1.71E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:2.76|P-value:9.28E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.08|P-value:3.06E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:2.80|P-value:8.05E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.85|P-value:6.60E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.61|P-value:2.42E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.79|P-value:9.53E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.01|P-value:9.01E-9 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.14|P-value:2.02E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:2.78|P-value:8.60E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-2.93|P-value:5.49E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.28|P-value:1.11E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-2.81|P-value:8.83E-4 ID:SGTC_2155|Compound:5570423|FD-Score:2.96|P-value:4.29E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.04|P-value:3.06E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-2.97|P-value:4.68E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.45|P-value:6.06E-5 ID:SGTC_2402|Compound:5553605|FD-Score:2.97|P-value:4.09E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.12|P-value:2.57E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.31|P-value:9.90E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.53|P-value:2.16E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.39|P-value:5.00E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-6.13|P-value:3.96E-12 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.86|P-value:6.37E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.10|P-value:2.36E-6 ID:SGTC_2783|Compound:7738165|FD-Score:-3.92|P-value:6.15E-6 ID:SGTC_2811|Compound:7967822|FD-Score:3.06|P-value:2.87E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.91|P-value:5.48E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-2.97|P-value:4.75E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.88|P-value:6.80E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.31|P-value:1.14E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.71|P-value:6.18E-8 ID:SGTC_3056|Compound:9094900|FD-Score:-3.27|P-value:1.32E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.85|P-value:2.57E-8 ID:SGTC_3089|Compound:9117425|FD-Score:-2.92|P-value:5.86E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.19|P-value:1.67E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.00|P-value:4.14E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-2.82|P-value:8.44E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.39|P-value:6.82E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.20|P-value:1.83E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.35|P-value:8.15E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.84|P-value:7.94E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.13|P-value:2.11E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.64|P-value:2.52E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:5.62|P-value:1.37E-10 ID:SGTC_443|Compound:clozapine|FD-Score:2.99|P-value:3.78E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.90|P-value:6.84E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:4.31|P-value:6.54E-7 ID:SGTC_500|Compound:h-89|FD-Score:2.96|P-value:4.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.18|P-value:1.71E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:2.76|P-value:9.28E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.08|P-value:3.06E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:2.80|P-value:8.05E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.85|P-value:6.60E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.61|P-value:2.42E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.79|P-value:9.53E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.01|P-value:9.01E-9 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.14|P-value:2.02E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:2.78|P-value:8.60E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-2.93|P-value:5.49E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.28|P-value:1.11E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-2.81|P-value:8.83E-4 ID:SGTC_2155|Compound:5570423|FD-Score:2.96|P-value:4.29E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.04|P-value:3.06E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-2.97|P-value:4.68E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.45|P-value:6.06E-5 ID:SGTC_2402|Compound:5553605|FD-Score:2.97|P-value:4.09E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.12|P-value:2.57E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.31|P-value:9.90E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.53|P-value:2.16E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.39|P-value:5.00E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-6.13|P-value:3.96E-12 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.86|P-value:6.37E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-4.10|P-value:2.36E-6 ID:SGTC_2783|Compound:7738165|FD-Score:-3.92|P-value:6.15E-6 ID:SGTC_2811|Compound:7967822|FD-Score:3.06|P-value:2.87E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.91|P-value:5.48E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-2.97|P-value:4.75E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.88|P-value:6.80E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.31|P-value:1.14E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.71|P-value:6.18E-8 ID:SGTC_3056|Compound:9094900|FD-Score:-3.27|P-value:1.32E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.85|P-value:2.57E-8 ID:SGTC_3089|Compound:9117425|FD-Score:-2.92|P-value:5.86E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.19|P-value:1.67E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.00|P-value:4.14E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-2.82|P-value:8.44E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.39|P-value:6.82E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.20|P-value:1.83E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.35|P-value:8.15E-5

Top fitness defect scores for YPL133C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_431 k089-0097 5.62 107.0 µM 1.37E-10 iron homeostasis 9 9.42E-9
2 SGTC_996 3970-0799 5.01 1.8 µM 9.01E-9 53 2.69E-7
3 SGTC_3063 1327-0034 4.85 4.0 µM 2.57E-8 31 6.22E-7
4 SGTC_2991 9074669 4.71 71.4 µM 6.18E-8 azole & statin 39 1.26E-6
5 SGTC_497 capsazepine 4.31 133.0 µM 6.54E-7 6 8.34E-6
6 SGTC_2822 7994718 3.91 71.4 µM 5.48E-6 17 4.59E-5
7 SGTC_922 1866-0035 3.61 480.0 µM 2.42E-5 excess fatty acid 76 1.52E-4
8 SGTC_3323 9138564 3.39 53.9 µM 6.82E-5 37 3.49E-4
9 SGTC_3345 9148410 3.35 3.6 µM 8.15E-5 18 4.02E-4
10 SGTC_2511 berberine 3.31 10.5 µM 9.90E-5 60S ribosome export 41 4.71E-4
11 SGTC_1842 st055362 3.28 61.2 µM 1.11E-4 33 5.15E-4
12 SGTC_3201 9113999 3.19 49.5 µM 1.67E-4 65 7.19E-4
13 SGTC_513 4245-1575 3.18 41.7 µM 1.71E-4 unfolded protein response 170 7.32E-4
14 SGTC_1187 1391-0724 3.14 117.0 µM 2.02E-4 amide catabolism 48 8.36E-4
15 SGTC_57 miconazole 3.13 162.5 nM 2.11E-4 ergosterol depletion effects on membrane 53 8.64E-4
16 SGTC_2811 7967822 3.06 32.5 µM 2.87E-4 54 0.00111
17 SGTC_2299 7976368 3.04 114.9 µM 3.06E-4 64 0.00117
18 SGTC_443 clozapine 2.99 122.0 µM 3.78E-4 NEO1-PIK1 26 0.00139
19 SGTC_2402 5553605 2.97 200.0 µM 4.09E-4 85 0.00148
20 SGTC_2155 5570423 2.96 76.0 µM 4.29E-4 ergosterol biosynthesis 45 0.00153

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 1.33E-36 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.172 1.34E-23 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.159 2.20E-20 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.158 2.81E-20 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.152 7.47E-19 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.140 3.84E-16 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.139 7.55E-16 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.137 1.78E-15 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.121 1.71E-12 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.121 2.12E-12 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.117 1.05E-11 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.117 1.12E-11 YJR094W-A RPL43B hom Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.115 2.06E-11 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.114 3.02E-11 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.114 3.29E-11 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated