YPL152W-A_p

Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL152W-A / YPL152W-A

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.22|P-value:2.69E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.60|P-value:4.88E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.25|P-value:2.15E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.09|P-value:4.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.66|P-value:2.67E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.53|P-value:7.26E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.05|P-value:5.09E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-2.88|P-value:8.89E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.93|P-value:1.05E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.49|P-value:7.85E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:-5.16|P-value:1.17E-8 ID:SGTC_647|Compound:0140-0236|FD-Score:3.06|P-value:5.04E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.99|P-value:8.51E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:-2.98|P-value:6.25E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.14|P-value:3.71E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.10|P-value:3.96E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.09|P-value:4.02E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.14|P-value:3.37E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.63|P-value:4.64E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:2.95|P-value:7.45E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:2.99|P-value:6.53E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.57|P-value:5.98E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.70|P-value:3.40E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.07|P-value:4.35E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-2.94|P-value:7.17E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.08|P-value:4.32E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.42|P-value:1.16E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.68|P-value:3.76E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.91|P-value:8.16E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.16|P-value:3.31E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.51|P-value:7.20E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.40|P-value:1.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.09|P-value:4.49E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.47|P-value:8.57E-5 ID:SGTC_2464|Compound:5717415|FD-Score:-3.33|P-value:1.54E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.76|P-value:2.37E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.05|P-value:4.71E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.14|P-value:3.31E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.29|P-value:2.03E-4 ID:SGTC_2790|Compound:5423970|FD-Score:2.98|P-value:6.84E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.22|P-value:2.69E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.60|P-value:4.88E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.25|P-value:2.15E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.09|P-value:4.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.66|P-value:2.67E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.53|P-value:7.26E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.05|P-value:5.09E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-2.88|P-value:8.89E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.93|P-value:1.05E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:-3.49|P-value:7.85E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:-5.16|P-value:1.17E-8 ID:SGTC_647|Compound:0140-0236|FD-Score:3.06|P-value:5.04E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.99|P-value:8.51E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:-2.98|P-value:6.25E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.14|P-value:3.71E-6 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.10|P-value:3.96E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.09|P-value:4.02E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.14|P-value:3.37E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.63|P-value:4.64E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:2.95|P-value:7.45E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:2.99|P-value:6.53E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.57|P-value:5.98E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.70|P-value:3.40E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.07|P-value:4.35E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.42|P-value:1.15E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-2.94|P-value:7.17E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.08|P-value:4.32E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.42|P-value:1.16E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.68|P-value:3.76E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.91|P-value:8.16E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.16|P-value:3.31E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.51|P-value:7.20E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.40|P-value:1.27E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.09|P-value:4.49E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.47|P-value:8.57E-5 ID:SGTC_2464|Compound:5717415|FD-Score:-3.33|P-value:1.54E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.76|P-value:2.37E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.05|P-value:4.71E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.14|P-value:3.31E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.29|P-value:2.03E-4 ID:SGTC_2790|Compound:5423970|FD-Score:2.98|P-value:6.84E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.07|P-value:4.88E-4

Top fitness defect scores for YPL152W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 4.66 5.3 µM 2.67E-7 345 1.62E-6
2 SGTC_648 0375-0473 3.99 33.3 µM 8.51E-6 15 3.24E-5
3 SGTC_1271 0832-2808 3.70 169.0 µM 3.40E-5 19 1.07E-4
4 SGTC_1736 st036774 3.68 51.0 µM 3.76E-5 44 1.17E-4
5 SGTC_1054 3429-0080 3.63 167.0 µM 4.64E-5 34 1.41E-4
6 SGTC_1194 1488-0194 3.57 225.0 µM 5.98E-5 46 1.76E-4
7 SGTC_275 trichlorophene 3.53 5.7 µM 7.26E-5 mitochondrial stress 249 2.08E-4
8 SGTC_1559 coumarin 343 3.42 70.1 µM 1.15E-4 19 3.10E-4
9 SGTC_1727 st034309 3.42 9.9 µM 1.16E-4 69 3.11E-4
10 SGTC_2133 5320837 3.40 200.0 µM 1.27E-4 ERG2 45 3.36E-4
11 SGTC_2780 5215298 3.29 71.4 µM 2.03E-4 71 5.07E-4
12 SGTC_34 0469-0683 3.22 81.8 µM 2.69E-4 SWF1 & branched chain AA biosynthesis 54 6.48E-4
13 SGTC_2042 p-Dimethylaminoacetophenone 3.16 200.0 µM 3.31E-4 49 7.75E-4
14 SGTC_2302 7771753 3.09 200.0 µM 4.49E-4 89 0.00101
15 SGTC_3202 9113761 3.07 49.5 µM 4.88E-4 96 0.00109
16 SGTC_647 0140-0236 3.06 81.0 µM 5.04E-4 35 0.00112
17 SGTC_358 0075-0058 3.05 9.4 µM 5.09E-4 125 0.00113
18 SGTC_323 4013-0906 3.00 34.3 µM 6.22E-4 ERG2 38 0.00134
19 SGTC_1090 efavirenz 2.99 20.7 µM 6.53E-4 60 0.00140
20 SGTC_2790 5423970 2.98 71.4 µM 6.84E-4 endomembrane recycling 122 0.00146

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.231 9.41E-42 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.221 2.55E-38 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.212 1.84E-35 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.205 4.61E-33 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.197 8.47E-31 YBL080C PET112 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
0.194 8.67E-30 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.190 1.32E-28 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.184 8.13E-27 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.183 1.08E-26 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.183 1.16E-26 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.182 2.04E-26 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.180 6.06E-26 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.179 1.49E-25 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.177 6.68E-25 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.176 1.04E-24 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit