YPL155C / KIP2

Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL155C / KIP2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.42|P-value:5.27E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:7.30|P-value:1.09E-16 ID:SGTC_253|Compound:dyclonine|FD-Score:2.88|P-value:5.35E-4 ID:SGTC_271|Compound:rotenone|FD-Score:2.82|P-value:6.64E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.23|P-value:1.24E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.22|P-value:1.27E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.78|P-value:9.56E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:3.44|P-value:4.89E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.04|P-value:4.31E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:2.76|P-value:8.56E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.08|P-value:2.35E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.15|P-value:1.77E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.86|P-value:8.65E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.02|P-value:3.04E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.92|P-value:4.59E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.05|P-value:2.73E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.97|P-value:3.64E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.98|P-value:3.61E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.94|P-value:4.26E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.48|P-value:4.09E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.43|P-value:2.84E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.17|P-value:1.59E-4 ID:SGTC_2194|Compound:5927483|FD-Score:2.78|P-value:7.80E-4 ID:SGTC_2200|Compound:6600604|FD-Score:2.93|P-value:4.29E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-7.66|P-value:9.89E-18 ID:SGTC_2241|Compound:6772625|FD-Score:-4.95|P-value:2.29E-8 ID:SGTC_2246|Compound:7293507|FD-Score:5.23|P-value:1.92E-9 ID:SGTC_2340|Compound:7987427|FD-Score:3.15|P-value:1.73E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.97|P-value:3.51E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.10|P-value:2.13E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.53|P-value:3.22E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.68|P-value:2.51E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:2.77|P-value:8.09E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.66|P-value:2.87E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.07|P-value:3.85E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.35|P-value:7.21E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.07|P-value:2.42E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.24|P-value:1.87E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.88|P-value:5.31E-4 ID:SGTC_2806|Compound:7952793|FD-Score:2.93|P-value:4.29E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.17|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.12|P-value:2.03E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.32|P-value:1.32E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.82|P-value:1.32E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.08|P-value:3.48E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-3.40|P-value:9.25E-5 ID:SGTC_3017|Compound:9080681|FD-Score:-3.33|P-value:1.26E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.71|P-value:1.33E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-2.94|P-value:6.36E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-4.00|P-value:5.15E-6 ID:SGTC_3074|Compound:9116018|FD-Score:-3.37|P-value:1.06E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.96|P-value:3.68E-6 ID:SGTC_3170|Compound:9103054|FD-Score:3.16|P-value:1.70E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.21|P-value:2.09E-9 ID:SGTC_50|Compound:0929-0078|FD-Score:3.42|P-value:5.27E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:7.30|P-value:1.09E-16 ID:SGTC_253|Compound:dyclonine|FD-Score:2.88|P-value:5.35E-4 ID:SGTC_271|Compound:rotenone|FD-Score:2.82|P-value:6.64E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.23|P-value:1.24E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.22|P-value:1.27E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.78|P-value:9.56E-6 ID:SGTC_518|Compound:1021-0119|FD-Score:3.44|P-value:4.89E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.04|P-value:4.31E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:2.76|P-value:8.56E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.08|P-value:2.35E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.15|P-value:1.77E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.86|P-value:8.65E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.02|P-value:3.04E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.92|P-value:4.59E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.05|P-value:2.73E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.97|P-value:3.64E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.98|P-value:3.61E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.94|P-value:4.26E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.48|P-value:4.09E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.43|P-value:2.84E-7 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.17|P-value:1.59E-4 ID:SGTC_2194|Compound:5927483|FD-Score:2.78|P-value:7.80E-4 ID:SGTC_2200|Compound:6600604|FD-Score:2.93|P-value:4.29E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-7.66|P-value:9.89E-18 ID:SGTC_2241|Compound:6772625|FD-Score:-4.95|P-value:2.29E-8 ID:SGTC_2246|Compound:7293507|FD-Score:5.23|P-value:1.92E-9 ID:SGTC_2340|Compound:7987427|FD-Score:3.15|P-value:1.73E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.97|P-value:3.51E-6 ID:SGTC_2424|Compound:5537928|FD-Score:3.10|P-value:2.13E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.53|P-value:3.22E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.68|P-value:2.51E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:2.77|P-value:8.09E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.66|P-value:2.87E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.07|P-value:3.85E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.35|P-value:7.21E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.07|P-value:2.42E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.24|P-value:1.87E-4 ID:SGTC_2797|Compound:7859098|FD-Score:2.88|P-value:5.31E-4 ID:SGTC_2806|Compound:7952793|FD-Score:2.93|P-value:4.29E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.17|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.12|P-value:2.03E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.32|P-value:1.32E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.82|P-value:1.32E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.08|P-value:3.48E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-3.40|P-value:9.25E-5 ID:SGTC_3017|Compound:9080681|FD-Score:-3.33|P-value:1.26E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.71|P-value:1.33E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-2.94|P-value:6.36E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-4.00|P-value:5.15E-6 ID:SGTC_3074|Compound:9116018|FD-Score:-3.37|P-value:1.06E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.96|P-value:3.68E-6 ID:SGTC_3170|Compound:9103054|FD-Score:3.16|P-value:1.70E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.21|P-value:2.09E-9

Top fitness defect scores for YPL155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 7.30 266.0 µM 1.09E-16 ubiquinone biosynthesis & proteasome 46 1.39E-13
2 SGTC_2246 7293507 5.23 91.6 µM 1.92E-9 16 8.70E-8
3 SGTC_3202 9113761 5.21 49.5 µM 2.09E-9 19 9.29E-8
4 SGTC_2125 5246583 4.43 200.0 µM 2.84E-7 tubulin folding & SWR complex 33 4.73E-6
5 SGTC_2397 5161689 3.97 200.0 µM 3.51E-6 34 3.55E-5
6 SGTC_3137 9097352 3.96 49.5 µM 3.68E-6 41 3.68E-5
7 SGTC_479 n-linoleoylglycine 3.78 10.0 µM 9.56E-6 11 7.91E-5
8 SGTC_3043 9092303 3.71 49.5 µM 1.33E-5 25 1.03E-4
9 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.53 92.6 µM 3.22E-5 37 2.09E-4
10 SGTC_2022 5136654 3.48 200.0 µM 4.09E-5 34 2.54E-4
11 SGTC_518 1021-0119 3.44 62.6 µM 4.89E-5 ERG2 66 2.93E-4
12 SGTC_50 0929-0078 3.42 56.4 µM 5.27E-5 72 3.11E-4
13 SGTC_2732 terfenadine 3.35 20.0 µM 7.21E-5 ERG2 12 3.99E-4
14 SGTC_274 sirtinol 3.23 40.1 µM 1.24E-4 47 6.17E-4
15 SGTC_297 0986-0032 3.22 24.0 µM 1.27E-4 60S ribosome export 23 6.30E-4
16 SGTC_2131 toluylene red 3.17 5.3 µM 1.59E-4 60S ribosome export 63 7.54E-4
17 SGTC_2835 9006588 3.17 71.4 µM 1.60E-4 83 7.56E-4
18 SGTC_3170 9103054 3.16 49.5 µM 1.70E-4 60S ribosome export 46 7.96E-4
19 SGTC_2340 7987427 3.15 183.4 µM 1.73E-4 68 8.07E-4
20 SGTC_1277 0873-0036 3.15 22.0 µM 1.77E-4 PDR1 60 8.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 9.75E-28 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.158 2.83E-20 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.153 4.95E-19 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.128 8.98E-14 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.126 2.94E-13 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.121 1.67E-12 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.120 2.83E-12 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.120 3.25E-12 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.120 3.53E-12 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.116 1.63E-11 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.116 1.85E-11 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.113 4.54E-11 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.113 5.56E-11 YLR127C APC2 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
0.112 6.73E-11 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.112 6.98E-11 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER