YPL179W / PPQ1

Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL179W / PPQ1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.67|P-value:5.89E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:5.26|P-value:6.29E-8 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.23|P-value:5.36E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.12|P-value:8.81E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.12|P-value:1.79E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.87|P-value:5.03E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.87|P-value:5.16E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.33|P-value:3.75E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.00|P-value:2.49E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.78|P-value:7.24E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.21|P-value:6.31E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.30|P-value:4.15E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.09|P-value:8.78E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.61|P-value:1.43E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.15|P-value:7.23E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.46|P-value:2.60E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.80|P-value:6.78E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.18|P-value:7.19E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.79|P-value:7.15E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.19|P-value:1.27E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.15|P-value:7.83E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.83|P-value:5.88E-5 ID:SGTC_2399|Compound:5884133|FD-Score:5.29|P-value:5.38E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.17|P-value:6.68E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.29|P-value:4.76E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.22|P-value:6.26E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.78|P-value:7.41E-5 ID:SGTC_3001|Compound:9076041|FD-Score:5.08|P-value:1.61E-7 ID:SGTC_3037|Compound:9091026|FD-Score:-3.58|P-value:1.49E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.22|P-value:6.06E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-3.22|P-value:5.59E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.21|P-value:5.85E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.67|P-value:5.89E-15 ID:SGTC_103|Compound:0844-0104|FD-Score:5.26|P-value:6.29E-8 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.23|P-value:5.36E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.12|P-value:8.81E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.12|P-value:1.79E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.87|P-value:5.03E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.87|P-value:5.16E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.33|P-value:3.75E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.00|P-value:2.49E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.78|P-value:7.24E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.21|P-value:6.31E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.30|P-value:4.15E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.09|P-value:8.78E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.61|P-value:1.43E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.15|P-value:7.23E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.46|P-value:2.60E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.80|P-value:6.78E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.18|P-value:7.19E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.79|P-value:7.15E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.06|P-value:2.26E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.19|P-value:1.27E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.15|P-value:7.83E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.83|P-value:5.88E-5 ID:SGTC_2399|Compound:5884133|FD-Score:5.29|P-value:5.38E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.17|P-value:6.68E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.29|P-value:4.76E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.22|P-value:6.26E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.78|P-value:7.41E-5 ID:SGTC_3001|Compound:9076041|FD-Score:5.08|P-value:1.61E-7 ID:SGTC_3037|Compound:9091026|FD-Score:-3.58|P-value:1.49E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.22|P-value:6.06E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-3.22|P-value:5.59E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.21|P-value:5.85E-4

Top fitness defect scores for YPL179W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 7.67 9.0 µM 5.89E-15 cell wall 135 8.43E-15
2 SGTC_2399 5884133 5.29 200.0 µM 5.38E-8 cell wall signaling 36 6.25E-8
3 SGTC_103 0844-0104 5.26 51.8 µM 6.29E-8 ERAD & cell cycle 96 7.29E-8
4 SGTC_3001 9076041 5.08 71.4 µM 1.61E-7 5 1.84E-7
5 SGTC_513 4245-1575 5.00 41.7 µM 2.49E-7 unfolded protein response 73 2.84E-7
6 SGTC_2307 7538926 4.19 6.3 µM 1.27E-5 34 1.38E-5
7 SGTC_211 3455-0679 4.12 143.5 µM 1.79E-5 16 1.93E-5
8 SGTC_2184 6075246 4.06 200.0 µM 2.26E-5 21 2.44E-5
9 SGTC_227 fluconazole 3.87 33.5 µM 5.03E-5 azole & statin 87 5.38E-5
10 SGTC_310 1273-0058 3.87 1.1 µM 5.16E-5 mitochondrial stress 250 5.52E-5
11 SGTC_2388 9080168 3.83 200.0 µM 5.88E-5 5 6.28E-5
12 SGTC_1966 st070145 3.80 16.1 µM 6.78E-5 26 7.23E-5
13 SGTC_2035 5154463 3.79 94.6 µM 7.15E-5 17 7.62E-5
14 SGTC_752 1896-0090 3.78 130.0 µM 7.24E-5 TSC3-RPN4 20 7.72E-5
15 SGTC_2939 9044578 3.78 71.4 µM 7.41E-5 46 7.89E-5
16 SGTC_1284 0929-0043 3.63 16.0 µM 1.33E-4 34 1.41E-4
17 SGTC_1917 st066507 3.61 28.5 µM 1.43E-4 Golgi 52 1.51E-4
18 SGTC_1956 st077085 3.46 54.0 µM 2.60E-4 34 2.73E-4
19 SGTC_2445 5742597 3.29 35.6 µM 4.76E-4 61 4.97E-4
20 SGTC_525 k781-2675 3.23 26.7 µM 5.94E-4 redox potentiating 80 6.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 8.24E-46 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.224 2.27E-39 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.222 1.95E-38 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.221 1.59E-38 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.220 5.88E-38 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.213 1.23E-35 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.205 4.12E-33 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.200 1.19E-31 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.190 1.10E-28 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.189 2.58E-28 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.189 3.15E-28 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.188 4.78E-28 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.186 1.51E-27 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.186 1.92E-27 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.181 4.33E-26 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1