YPL199C_p

Putative protein of unknown function, predicted to be palmitoylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL199C / YPL199C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:8.22|P-value:1.41E-16 ID:SGTC_57|Compound:miconazole|FD-Score:3.16|P-value:8.20E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.43|P-value:3.24E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.89|P-value:5.54E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:3.80|P-value:7.71E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.23|P-value:6.47E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-5.65|P-value:9.50E-9 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.54|P-value:2.13E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.01|P-value:3.28E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.56|P-value:1.95E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.34|P-value:4.38E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.73|P-value:1.04E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.22|P-value:6.75E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.32|P-value:8.68E-6 ID:SGTC_1780|Compound:st038448|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.21|P-value:7.04E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.72|P-value:1.08E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.11|P-value:9.79E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.10|P-value:1.90E-7 ID:SGTC_2138|Compound:5575593|FD-Score:3.78|P-value:8.41E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-4.18|P-value:1.62E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.71|P-value:1.12E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.28|P-value:1.05E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.61|P-value:1.63E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.43|P-value:3.21E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.32|P-value:8.64E-6 ID:SGTC_2678|Compound:equilin|FD-Score:-3.53|P-value:2.18E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.55|P-value:2.03E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.81|P-value:7.58E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.01|P-value:3.34E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.32|P-value:4.78E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.31|P-value:4.87E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.27|P-value:5.78E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.87|P-value:5.95E-5 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:2.42E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.90|P-value:5.27E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.24|P-value:6.32E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.34|P-value:7.92E-6 ID:SGTC_3163|Compound:9099914|FD-Score:3.41|P-value:3.47E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.81|P-value:7.39E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.35|P-value:4.21E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:8.22|P-value:1.41E-16 ID:SGTC_57|Compound:miconazole|FD-Score:3.16|P-value:8.20E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.43|P-value:3.24E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.89|P-value:5.54E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:3.80|P-value:7.71E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.23|P-value:6.47E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-5.65|P-value:9.50E-9 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.54|P-value:2.13E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.01|P-value:3.28E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.56|P-value:1.95E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.34|P-value:4.38E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.73|P-value:1.04E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.22|P-value:6.75E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.32|P-value:8.68E-6 ID:SGTC_1780|Compound:st038448|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.21|P-value:7.04E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.72|P-value:1.08E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.11|P-value:9.79E-4 ID:SGTC_2137|Compound:5261020|FD-Score:5.10|P-value:1.90E-7 ID:SGTC_2138|Compound:5575593|FD-Score:3.78|P-value:8.41E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-4.18|P-value:1.62E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.71|P-value:1.12E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.28|P-value:1.05E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.61|P-value:1.63E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-3.59|P-value:1.79E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.43|P-value:3.21E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.32|P-value:8.64E-6 ID:SGTC_2678|Compound:equilin|FD-Score:-3.53|P-value:2.18E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.55|P-value:2.03E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.81|P-value:7.58E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.01|P-value:3.34E-5 ID:SGTC_2881|Compound:9058953|FD-Score:3.32|P-value:4.78E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.31|P-value:4.87E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.27|P-value:5.78E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.87|P-value:5.95E-5 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:2.42E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.90|P-value:5.27E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.24|P-value:6.32E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.34|P-value:7.92E-6 ID:SGTC_3163|Compound:9099914|FD-Score:3.41|P-value:3.47E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.81|P-value:7.39E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.35|P-value:4.21E-4

Top fitness defect scores for YPL199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_50 0929-0078 8.22 56.4 µM 1.41E-16 15 1.00E-16
2 SGTC_2137 5261020 5.10 140.0 µM 1.90E-7 18 1.67E-7
3 SGTC_2992 9074591 4.34 71.4 µM 7.92E-6 11 7.19E-6
4 SGTC_2559 tetrahydrosappanone a trimethyl ether 4.32 100.0 µM 8.64E-6 8 7.85E-6
5 SGTC_1532 4',5'-dihydroxyflavone 4.32 78.7 µM 8.68E-6 Golgi 17 7.89E-6
6 SGTC_504 lovastatin 4.01 124.0 µM 3.28E-5 14 3.02E-5
7 SGTC_2753 fluvastatin 4.00 17.1 µM 3.40E-5 azole & statin 35 3.13E-5
8 SGTC_3274 9138298 3.81 49.5 µM 7.39E-5 24 6.86E-5
9 SGTC_2691 st077356 3.81 60.2 µM 7.58E-5 33 7.03E-5
10 SGTC_327 1273-0057 3.80 4.0 µM 7.71E-5 azole & statin 37 7.15E-5
11 SGTC_2138 5575593 3.78 77.7 µM 8.41E-5 14 7.81E-5
12 SGTC_1245 0418-0076 3.73 17.2 µM 1.04E-4 ERG2 36 9.71E-5
13 SGTC_2332 7982454 3.71 138.9 µM 1.12E-4 59 1.04E-4
14 SGTC_2380 9035439 3.61 200.0 µM 1.63E-4 endomembrane recycling 38 1.52E-4
15 SGTC_2687 chenodiol 3.55 100.0 µM 2.03E-4 35 1.90E-4
16 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.54 150.0 µM 2.13E-4 Golgi 54 1.99E-4
17 SGTC_2971 9092186 3.51 9.9 µM 2.42E-4 ergosterol biosynthesis 46 2.27E-4
18 SGTC_2511 berberine 3.43 10.5 µM 3.21E-4 60S ribosome export 35 3.02E-4
19 SGTC_1780 st038448 3.43 24.5 µM 3.23E-4 iron homeostasis 38 3.04E-4
20 SGTC_3163 9099914 3.41 49.5 µM 3.47E-4 4 3.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.27E-19 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.110 1.51E-10 YOR334W MRS2 hom Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
0.109 2.59E-10 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.52E-9 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.093 6.27E-8 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.083 1.32E-6 YNL290W RFC3 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.083 1.44E-6 YJL186W MNN5 hom Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.081 2.96E-6 YKR027W BCH2 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.080 3.71E-6 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.078 5.80E-6 YIL006W YIA6 hom Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
0.078 6.57E-6 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.077 8.20E-6 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.076 1.19E-5 YOR147W MDM32 hom Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
0.075 1.20E-5 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.075 1.52E-5 YLR046C_p YLR046C_p hom Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance