YPL213W / LEA1

Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL213W / LEA1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.17|P-value:6.27E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.10|P-value:8.17E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.22|P-value:5.20E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.21|P-value:9.14E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.98|P-value:1.60E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:3.67|P-value:9.34E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:7.71|P-value:1.89E-15 ID:SGTC_232|Compound:clozapine|FD-Score:3.67|P-value:9.43E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.80|P-value:5.38E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.22|P-value:5.22E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.67|P-value:9.44E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.02|P-value:2.14E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.07|P-value:8.82E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.94|P-value:3.06E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.33|P-value:4.53E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.15|P-value:6.67E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.50|P-value:2.30E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:6.27|P-value:8.13E-11 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.12|P-value:6.66E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.67|P-value:9.18E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.02|P-value:9.57E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.50|P-value:2.31E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.45|P-value:2.87E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.12|P-value:7.54E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.16|P-value:6.59E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.14|P-value:6.92E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.78|P-value:6.06E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.45|P-value:2.19E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.69|P-value:8.94E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.19|P-value:5.92E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:5.67|P-value:3.81E-9 ID:SGTC_1750|Compound:st081859|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.21|P-value:5.59E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.07|P-value:1.70E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.64|P-value:1.07E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.67|P-value:9.51E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.80|P-value:5.47E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.53|P-value:1.95E-6 ID:SGTC_2066|Compound:5222451|FD-Score:3.30|P-value:3.99E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.17|P-value:6.27E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.15|P-value:6.66E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.35|P-value:3.23E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.31|P-value:3.79E-4 ID:SGTC_2365|Compound:9042475|FD-Score:6.62|P-value:7.41E-12 ID:SGTC_2434|Compound:5670830|FD-Score:3.63|P-value:1.12E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.16|P-value:6.59E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.99|P-value:2.42E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.71|P-value:7.90E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-5.58|P-value:5.34E-9 ID:SGTC_2787|Compound:5284540|FD-Score:-3.70|P-value:7.32E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.22|P-value:5.35E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.17|P-value:1.10E-5 ID:SGTC_2910|Compound:7948405|FD-Score:-3.54|P-value:1.37E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.28|P-value:4.31E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.84|P-value:4.59E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.49|P-value:1.90E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.05|P-value:9.72E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.17|P-value:6.27E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.10|P-value:8.17E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.22|P-value:5.20E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.21|P-value:9.14E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.98|P-value:1.60E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:3.67|P-value:9.34E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:7.71|P-value:1.89E-15 ID:SGTC_232|Compound:clozapine|FD-Score:3.67|P-value:9.43E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.80|P-value:5.38E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.22|P-value:5.22E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:4.15|P-value:1.17E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.67|P-value:9.44E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.02|P-value:2.14E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.07|P-value:8.82E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.94|P-value:3.06E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.33|P-value:4.53E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.15|P-value:6.67E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.50|P-value:2.30E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:6.27|P-value:8.13E-11 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.12|P-value:6.66E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.67|P-value:9.18E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.02|P-value:9.57E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.50|P-value:2.31E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.45|P-value:2.87E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.12|P-value:7.54E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.16|P-value:6.59E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.14|P-value:6.92E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.78|P-value:6.06E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.45|P-value:2.19E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.69|P-value:8.94E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.19|P-value:5.92E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:5.67|P-value:3.81E-9 ID:SGTC_1750|Compound:st081859|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_1826|Compound:st055655|FD-Score:5.21|P-value:5.59E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.07|P-value:1.70E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.64|P-value:1.07E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.67|P-value:9.51E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.80|P-value:5.47E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.53|P-value:1.95E-6 ID:SGTC_2066|Compound:5222451|FD-Score:3.30|P-value:3.99E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.17|P-value:6.27E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.15|P-value:6.66E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.35|P-value:3.23E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.62|P-value:1.15E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.31|P-value:3.79E-4 ID:SGTC_2365|Compound:9042475|FD-Score:6.62|P-value:7.41E-12 ID:SGTC_2434|Compound:5670830|FD-Score:3.63|P-value:1.12E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.16|P-value:6.59E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.99|P-value:2.42E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.71|P-value:7.90E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-5.58|P-value:5.34E-9 ID:SGTC_2787|Compound:5284540|FD-Score:-3.70|P-value:7.32E-5 ID:SGTC_2855|Compound:9016525|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.22|P-value:5.35E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.17|P-value:1.10E-5 ID:SGTC_2910|Compound:7948405|FD-Score:-3.54|P-value:1.37E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.28|P-value:4.31E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.84|P-value:4.59E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.49|P-value:1.90E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.05|P-value:9.72E-4

Top fitness defect scores for YPL213W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_69 0096-0274 7.71 206.7 µM 1.89E-15 mitochondrial processes 4 6.47E-15
2 SGTC_2365 9042475 6.62 200.0 µM 7.41E-12 7 1.81E-11
3 SGTC_808 0711-0032 6.27 135.0 µM 8.13E-11 4 1.81E-10
4 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 5.67 19.1 µM 3.81E-9 5 7.29E-9
5 SGTC_1826 st055655 5.21 41.6 µM 5.59E-8 ERG2 19 9.62E-8
6 SGTC_1484 3473-2379 4.69 286.0 µM 8.94E-7 6 1.38E-6
7 SGTC_2057 5236571 4.53 38.3 µM 1.95E-6 RPP1 & pyrimidine depletion 17 2.93E-6
8 SGTC_806 3966-4455 4.50 5.9 µM 2.30E-6 11 3.44E-6
9 SGTC_1100 amiodarone 4.50 5.1 µM 2.31E-6 8 3.44E-6
10 SGTC_1122 capsaicin 4.45 818.6 nM 2.87E-6 18 4.24E-6
11 SGTC_44 0929-0055 4.21 61.2 µM 9.14E-6 28 1.29E-5
12 SGTC_2908 7930301 4.17 100.0 µM 1.10E-5 20 1.54E-5
13 SGTC_326 k292-0812 4.15 17.5 µM 1.17E-5 5 1.65E-5
14 SGTC_1875 nocodazole 4.07 6.0 µM 1.70E-5 tubulin folding & SWR complex 49 2.35E-5
15 SGTC_535 2293-4129 4.02 48.2 µM 2.14E-5 NEO1 57 2.93E-5
16 SGTC_2598 perillyl alcohol 3.99 100.0 µM 2.42E-5 30 3.30E-5
17 SGTC_710 3448-4187 3.94 58.0 µM 3.06E-5 fatty acid desaturase (OLE1) 59 4.13E-5
18 SGTC_3072 9116419 3.84 49.5 µM 4.59E-5 ERG2 19 6.10E-5
19 SGTC_241 5hr heat shock (37°C) + cantharidin 3.80 155.4 µM 5.38E-5 cell wall signaling 78 7.12E-5
20 SGTC_2056 5235370 3.80 200.0 µM 5.47E-5 46 7.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.62E-16 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.133 9.16E-15 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.131 2.76E-14 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.103 1.95E-9 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.095 4.07E-8 YBR087W RFC5 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.094 4.63E-8 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.093 7.74E-8 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.092 8.26E-8 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.089 2.43E-7 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.086 6.20E-7 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.085 8.22E-7 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.085 8.64E-7 YOL143C RIB4 hom Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
0.084 9.91E-7 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.083 1.52E-6 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.082 1.88E-6 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p