HIPHOP chemogenomics database

YPL215W / CBP3

Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL215W / CBP3

Click on Significant Values for Screen Details

Top fitness defect scores for YPL215W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	27.50	5.3 µM	9.98E-196		22	1.81E-166
2	SGTC_1635	st007035	15.10	42.4 µM	1.17E-60		40	1.05E-51
3	SGTC_386	1509-0011	14.60	3.1 µM	6.18E-57		22	1.52E-48
4	SGTC_2982	9019404	6.62	26.0 µM	2.70E-13		4	1.76E-11
5	SGTC_705	1124-0212	5.63	310.0 µM	4.10E-10		3	8.86E-9
6	SGTC_2307	7538926	5.42	6.3 µM	1.75E-9		11	3.04E-8
7	SGTC_824	1304-0008	5.22	100.0 µM	6.18E-9	DNA damage response	19	8.88E-8
8	SGTC_908	3448-7491	5.08	47.7 µM	1.48E-8	mitochondrial stress	75	1.87E-7
9	SGTC_59	0330-0160	4.90	1.3 µM	4.62E-8		62	4.91E-7
10	SGTC_2985	9022375	4.81	71.4 µM	7.64E-8	RPP1 & pyrimidine depletion	15	7.53E-7
11	SGTC_168	3970-0862	4.63	530.5 µM	2.11E-7		83	1.79E-6
12	SGTC_134	0269-0018	4.31	6.9 µM	1.28E-6		117	8.29E-6
13	SGTC_704	1310-0270	4.11	142.0 µM	3.52E-6		30	1.96E-5
14	SGTC_149	3970-0822	4.04	46.1 µM	5.20E-6	tubulin folding & SWR complex	94	2.73E-5
15	SGTC_214	4373-3496	4.00	70.0 µM	6.31E-6		55	3.22E-5
16	SGTC_2250	alverine citrate	3.72	130.0 µM	2.34E-5		177	9.81E-5
17	SGTC_2602	kawain	3.66	100.0 µM	3.20E-5		36	1.28E-4
18	SGTC_181	1447-1644	3.61	8.1 µM	3.92E-5	endomembrane recycling	42	1.52E-4
19	SGTC_3302	9125395	3.49	16.4 µM	6.71E-5		26	2.41E-4
20	SGTC_3038	9091290	3.40	49.5 µM	9.76E-5		32	3.31E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	ORF	Gene	Zygosity	Description
0.759	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.751	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.700	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.697	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.691	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.683	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.678	YHR116W	COX23	hom	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.674	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.672	YJL022W_d	YJL022W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.672	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.667	YER058W	PET117	hom	Protein required for assembly of cytochrome c oxidase
0.665	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.648	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.640	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.640	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p