YPL223C / GRE1

Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL223C / GRE1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-6.24|P-value:6.57E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:-4.80|P-value:1.50E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.86|P-value:1.07E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-6.77|P-value:2.35E-11 ID:SGTC_364|Compound:0083-0097|FD-Score:6.98|P-value:9.04E-12 ID:SGTC_704|Compound:1310-0270|FD-Score:5.98|P-value:4.35E-9 ID:SGTC_726|Compound:3448-4391|FD-Score:3.46|P-value:4.64E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:5.30|P-value:1.79E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.28|P-value:6.84E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.76|P-value:1.55E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.69|P-value:2.03E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.49|P-value:4.18E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.30|P-value:1.41E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.42|P-value:4.24E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.86|P-value:8.53E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.50|P-value:4.05E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-3.32|P-value:6.00E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.20|P-value:2.12E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.23|P-value:2.47E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.24|P-value:7.76E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.31|P-value:1.34E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.57|P-value:2.45E-4 ID:SGTC_3353|Compound:9151644|FD-Score:4.00|P-value:6.25E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-6.24|P-value:6.57E-10 ID:SGTC_43|Compound:0570-0105|FD-Score:-4.80|P-value:1.50E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.86|P-value:1.07E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-6.77|P-value:2.35E-11 ID:SGTC_364|Compound:0083-0097|FD-Score:6.98|P-value:9.04E-12 ID:SGTC_704|Compound:1310-0270|FD-Score:5.98|P-value:4.35E-9 ID:SGTC_726|Compound:3448-4391|FD-Score:3.46|P-value:4.64E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:5.30|P-value:1.79E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.65|P-value:1.85E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:-3.28|P-value:6.84E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.76|P-value:1.55E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.69|P-value:2.03E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.49|P-value:4.18E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.30|P-value:1.41E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.42|P-value:4.24E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.86|P-value:8.53E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.50|P-value:4.05E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-3.32|P-value:6.00E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.20|P-value:2.12E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.23|P-value:2.47E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.24|P-value:7.76E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.31|P-value:1.34E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.57|P-value:2.45E-4 ID:SGTC_3353|Compound:9151644|FD-Score:4.00|P-value:6.25E-5

Top fitness defect scores for YPL223C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_364 0083-0097 6.98 67.7 µM 9.04E-12 4 1.46E-12
2 SGTC_704 1310-0270 5.98 142.0 µM 4.35E-9 7 1.10E-9
3 SGTC_762 1165-0429 5.30 115.0 µM 1.79E-7 TSC3-RPN4 4 5.93E-8
4 SGTC_2755 lomerizine 5.23 42.7 µM 2.47E-7 7 8.38E-8
5 SGTC_3353 9151644 4.00 39.3 µM 6.25E-5 11 3.18E-5
6 SGTC_44 0929-0055 3.86 61.2 µM 1.07E-4 34 5.68E-5
7 SGTC_1416 3966-0321 3.76 25.3 µM 1.55E-4 19 8.47E-5
8 SGTC_1457 k015-0032 3.69 57.3 µM 2.03E-4 44 1.13E-4
9 SGTC_1949 st076024 3.62 69.1 µM 2.58E-4 38 1.46E-4
10 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.50 3.7 µM 4.05E-4 128 2.37E-4
11 SGTC_1782 st039423 3.49 80.6 µM 4.18E-4 32 2.45E-4
12 SGTC_726 3448-4391 3.46 34.2 µM 4.64E-4 27 2.74E-4
13 SGTC_944 3370-0224 3.21 231.0 µM 0.00106 60 6.68E-4
14 SGTC_1348 1493-0373 3.20 93.8 µM 0.00111 36 6.96E-4
15 SGTC_2361 9034121 3.19 116.0 µM 0.00112 RSC complex & mRNA processing 46 7.04E-4
16 SGTC_1016 4226-1401 3.14 38.0 µM 0.00132 RNA pol III & RNase P/MRP 47 8.39E-4
17 SGTC_453 enantio-paf c16 3.12 10.0 µM 0.00141 225 9.01E-4
18 SGTC_3301 9125354 3.11 19.8 µM 0.00146 34 9.41E-4
19 SGTC_3245 9134821 3.07 49.5 µM 0.00163 54 0.00105
20 SGTC_2775 cyproheptadine 3.05 69.6 µM 0.00174 40 0.00113

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.20E-23 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.169 6.27E-23 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.155 1.62E-19 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.139 6.04E-16 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.126 2.26E-13 YHR033W_p YHR033W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication
0.121 2.31E-12 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.120 3.47E-12 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.118 6.39E-12 YLR334C_d YLR334C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
0.115 2.88E-11 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.113 5.56E-11 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.112 7.09E-11 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.104 1.71E-9 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.61E-9 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.102 2.95E-9 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.101 5.51E-9 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant