YPL277C_p

Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL277C / YPL277C

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:3.73|P-value:2.84E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.80|P-value:1.94E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:4.81E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.01|P-value:5.49E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.05|P-value:2.42E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.67|P-value:3.74E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.98|P-value:6.51E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.07|P-value:4.28E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.88|P-value:1.28E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.26|P-value:2.13E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.24|P-value:2.25E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.47|P-value:8.84E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.67|P-value:2.26E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.07|P-value:4.42E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.09|P-value:4.30E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.05|P-value:4.65E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.95|P-value:7.38E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.05|P-value:5.01E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.19|P-value:2.87E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.07|P-value:4.53E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.10|P-value:4.70E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.87|P-value:9.44E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.96|P-value:7.00E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.65|P-value:4.03E-5 ID:SGTC_2453|Compound:5731132|FD-Score:2.92|P-value:8.02E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.06|P-value:4.50E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.04|P-value:5.23E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.73|P-value:2.84E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.80|P-value:1.94E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.06|P-value:4.81E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.01|P-value:5.49E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.05|P-value:2.42E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.67|P-value:3.74E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.98|P-value:6.51E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.07|P-value:4.28E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.88|P-value:1.28E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:3.26|P-value:2.13E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.24|P-value:2.25E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.47|P-value:8.84E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.67|P-value:2.26E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.07|P-value:4.42E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.09|P-value:4.30E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.05|P-value:4.65E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.95|P-value:7.38E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.21|P-value:2.68E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.05|P-value:5.01E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.19|P-value:2.87E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.07|P-value:4.53E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.10|P-value:4.70E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.87|P-value:9.44E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.96|P-value:7.00E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.65|P-value:4.03E-5 ID:SGTC_2453|Compound:5731132|FD-Score:2.92|P-value:8.02E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.06|P-value:4.50E-4 ID:SGTC_3021|Compound:9087658|FD-Score:3.04|P-value:5.23E-4

Top fitness defect scores for YPL277C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_386 1509-0011 5.05 3.1 µM 2.42E-8 106 2.19E-7
2 SGTC_635 k038-0028 4.67 24.7 µM 2.26E-7 ubiquinone biosynthesis & proteasome 35 1.50E-6
3 SGTC_2260 7964312 4.10 200.0 µM 4.70E-6 11 2.04E-5
4 SGTC_134 0269-0018 3.73 6.9 µM 2.84E-5 145 9.63E-5
5 SGTC_453 enantio-paf c16 3.67 10.0 µM 3.74E-5 169 1.22E-4
6 SGTC_2439 5492030 3.65 7.2 µM 4.03E-5 19 1.30E-4
7 SGTC_634 1611-4317 3.47 11.2 µM 8.84E-5 ERG2 30 2.57E-4
8 SGTC_623 k072-0108 3.26 16.9 µM 2.13E-4 heme biosynthesis & mitochondrial translocase 47 5.49E-4
9 SGTC_1828 st055811 3.21 49.0 µM 2.68E-4 23 6.69E-4
10 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.19 70.1 µM 2.87E-4 68 7.11E-4
11 SGTC_996 3970-0799 3.09 1.8 µM 4.30E-4 147 0.00101
12 SGTC_2200 6600604 3.07 21.9 µM 4.53E-4 tubulin folding & SWR complex 89 0.00105
13 SGTC_143 4032-1194 3.06 15.7 µM 4.81E-4 135 0.00111
14 SGTC_1854 st056233 3.05 32.9 µM 5.01E-4 amide catabolism 50 0.00115
15 SGTC_3021 9087658 3.04 49.5 µM 5.23E-4 23 0.00119
16 SGTC_457 grayanotoxin iii 2.98 135.0 µM 6.51E-4 144 0.00144
17 SGTC_2316 5844804 2.96 197.4 µM 7.00E-4 100 0.00154
18 SGTC_1451 4152-0210 2.95 104.0 µM 7.38E-4 76 0.00161
19 SGTC_2453 5731132 2.92 22.2 µM 8.02E-4 82 0.00173
20 SGTC_3293 9120939 2.79 62.0 µM 0.00131 73 0.00265

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.273 1.55E-58 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.265 5.06E-55 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.260 5.47E-53 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.243 2.55E-46 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.242 7.21E-46 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.236 1.70E-43 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.227 1.60E-40 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.227 1.95E-40 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.225 1.63E-39 YMR256C COX7 hom Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.216 9.75E-37 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.214 4.23E-36 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.211 4.24E-35 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.204 7.91E-33 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.201 8.65E-32 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.194 9.39E-30 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1