YPR003C_p

Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR003C / YPR003C

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.86|P-value:1.89E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.42|P-value:2.42E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.58|P-value:4.84E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.59|P-value:4.57E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.47|P-value:6.70E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.67|P-value:3.58E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.23|P-value:5.03E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:-5.36|P-value:7.81E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.67|P-value:3.59E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.87|P-value:1.82E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.91|P-value:1.57E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.51|P-value:6.06E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.47|P-value:6.72E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.41|P-value:8.23E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.45|P-value:7.21E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.14|P-value:6.93E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.33|P-value:3.43E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-4.00|P-value:1.81E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-4.58|P-value:2.12E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.10|P-value:1.26E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.67|P-value:3.52E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-3.81|P-value:3.43E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.71|P-value:3.12E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.73|P-value:4.38E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.40|P-value:8.52E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.65|P-value:5.77E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.02|P-value:1.06E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.87|P-value:1.78E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.51|P-value:6.04E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.06|P-value:9.13E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.69|P-value:5.02E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.74|P-value:6.76E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.08|P-value:8.61E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.86|P-value:1.89E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.42|P-value:2.42E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.58|P-value:4.84E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.59|P-value:4.57E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.47|P-value:6.70E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.67|P-value:3.58E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:4.23|P-value:5.03E-5 ID:SGTC_688|Compound:0527-0193|FD-Score:-5.36|P-value:7.81E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.67|P-value:3.59E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.87|P-value:1.82E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.91|P-value:1.57E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.51|P-value:6.06E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.47|P-value:6.72E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.41|P-value:8.23E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.45|P-value:7.21E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.14|P-value:6.93E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.33|P-value:3.43E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-4.00|P-value:1.81E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-4.58|P-value:2.12E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-4.10|P-value:1.26E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.67|P-value:3.52E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-3.81|P-value:3.43E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.71|P-value:3.12E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.73|P-value:4.38E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.40|P-value:8.52E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.65|P-value:5.77E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.02|P-value:1.06E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.87|P-value:1.78E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.51|P-value:6.04E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.06|P-value:9.13E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.69|P-value:5.02E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.74|P-value:6.76E-6 ID:SGTC_3208|Compound:9114115|FD-Score:4.08|P-value:8.61E-5

Top fitness defect scores for YPR003C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3131 9127911 4.74 49.5 µM 6.76E-6 13 1.09E-6
2 SGTC_60 0986-0278 4.42 202.0 µM 2.42E-5 6 5.00E-6
3 SGTC_1616 st002734 4.33 56.1 µM 3.43E-5 21 7.57E-6
4 SGTC_683 panaxydol 4.23 45.0 µM 5.03E-5 sphingolipid biosynthesis & PDR1 30 1.19E-5
5 SGTC_1602 st001878 4.14 87.6 µM 6.93E-5 17 1.74E-5
6 SGTC_3208 9114115 4.08 49.5 µM 8.61E-5 30 2.26E-5
7 SGTC_2611 pyromycin 4.06 23.9 µM 9.13E-5 24 2.42E-5
8 SGTC_2340 7987427 4.02 183.4 µM 1.06E-4 32 2.88E-5
9 SGTC_1168 k815-0004 3.91 80.5 µM 1.57E-4 DNA damage response 18 4.59E-5
10 SGTC_2341 7987486 3.87 176.7 µM 1.78E-4 19 5.35E-5
11 SGTC_1040 k898-0338 3.87 155.0 µM 1.82E-4 23 5.49E-5
12 SGTC_19 0279-0214 3.86 38.4 µM 1.89E-4 TRP & mitochondrial translation 40 5.74E-5
13 SGTC_2029 5175081 3.71 200.0 µM 3.12E-4 23 1.04E-4
14 SGTC_1834 st055981 3.68 52.8 µM 3.46E-4 RPP1 & pyrimidine depletion 39 1.18E-4
15 SGTC_1634 st006576 3.67 41.0 µM 3.52E-4 TSC3-RPN4 27 1.20E-4
16 SGTC_436 n,n-dimethylsphingosine 3.67 3.3 µM 3.58E-4 34 1.22E-4
17 SGTC_1038 k292-0204 3.67 154.0 µM 3.59E-4 25 1.23E-4
18 SGTC_272 doxorubicin 3.59 8.1 µM 4.57E-4 anthracycline transcription coupled DNA repair 31 1.63E-4
19 SGTC_135 0933-0004 3.58 26.4 µM 4.84E-4 60S ribosome export 34 1.75E-4
20 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 3.51 13.2 µM 6.04E-4 39 2.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 1.64E-7 YIL096C_p YIL096C_p hom Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis
0.089 2.38E-7 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.085 9.39E-7 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.083 1.55E-6 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.083 1.65E-6 YOR100C CRC1 hom Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
0.080 3.32E-6 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.076 1.12E-5 YMR012W CLU1 hom eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.075 1.35E-5 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.073 2.19E-5 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.072 2.98E-5 YCR083W TRX3 hom Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
0.071 3.57E-5 YML006C GIS4 hom CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
0.071 3.62E-5 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.070 4.46E-5 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.070 5.48E-5 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.067 1.07E-4 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene