YPR007C / REC8

Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR007C / REC8

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:3.29|P-value:5.26E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.85|P-value:6.25E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:3.62|P-value:1.51E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-5.52|P-value:1.50E-8 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.09|P-value:9.60E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.07|P-value:9.96E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.52|P-value:3.28E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:-3.16|P-value:7.55E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.88|P-value:5.38E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.45|P-value:2.90E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.53|P-value:2.16E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.37|P-value:5.80E-6 ID:SGTC_1651|Compound:st011928|FD-Score:-3.12|P-value:8.46E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.05|P-value:2.36E-5 ID:SGTC_1807|Compound:st050092|FD-Score:3.77|P-value:8.71E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.64|P-value:1.29E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.19|P-value:1.44E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.65|P-value:1.36E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.86|P-value:5.34E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.44|P-value:3.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.27|P-value:5.53E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.34|P-value:4.00E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.63|P-value:1.66E-6 ID:SGTC_2477|Compound:5967686|FD-Score:-3.70|P-value:9.87E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-4.69|P-value:1.28E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.12|P-value:8.44E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.57|P-value:1.70E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.49|P-value:2.51E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.81|P-value:7.30E-5 ID:SGTC_2854|Compound:9024559|FD-Score:3.25|P-value:5.95E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.13|P-value:9.17E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.98|P-value:3.60E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.29|P-value:5.26E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.85|P-value:6.25E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:3.62|P-value:1.51E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-5.52|P-value:1.50E-8 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.09|P-value:9.60E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.07|P-value:9.96E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:4.52|P-value:3.28E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:-3.16|P-value:7.55E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.88|P-value:5.38E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.45|P-value:2.90E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.53|P-value:2.16E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.37|P-value:5.80E-6 ID:SGTC_1651|Compound:st011928|FD-Score:-3.12|P-value:8.46E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-4.05|P-value:2.36E-5 ID:SGTC_1807|Compound:st050092|FD-Score:3.77|P-value:8.71E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-3.64|P-value:1.29E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.19|P-value:1.44E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.65|P-value:1.36E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.86|P-value:5.34E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.44|P-value:3.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.27|P-value:5.53E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.34|P-value:4.00E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.63|P-value:1.66E-6 ID:SGTC_2477|Compound:5967686|FD-Score:-3.70|P-value:9.87E-5 ID:SGTC_2481|Compound:5478948|FD-Score:-4.69|P-value:1.28E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.12|P-value:8.44E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.57|P-value:1.70E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.49|P-value:2.51E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.81|P-value:7.30E-5 ID:SGTC_2854|Compound:9024559|FD-Score:3.25|P-value:5.95E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.13|P-value:9.17E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.98|P-value:3.60E-5

Top fitness defect scores for YPR007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_725 1497-0963 4.52 19.0 µM 3.28E-6 copper-dependent oxidative stress 13 3.12E-6
2 SGTC_1934 st074720 4.19 32.6 µM 1.44E-5 44 1.37E-5
3 SGTC_3191 9110352 3.98 49.5 µM 3.60E-5 8 3.43E-5
4 SGTC_1206 3978-0017 3.88 132.0 µM 5.38E-5 ERG2 41 5.14E-5
5 SGTC_165 k038-0023 3.85 64.4 µM 6.25E-5 ubiquinone biosynthesis & proteasome 84 5.97E-5
6 SGTC_2804 7954240 3.81 19.5 µM 7.30E-5 38 6.97E-5
7 SGTC_1807 st050092 3.77 58.9 µM 8.71E-5 60S ribosome export 15 8.32E-5
8 SGTC_2007 4011539 3.65 71.8 µM 1.36E-4 cell wall signaling 79 1.30E-4
9 SGTC_340 k038-0059 3.62 454.0 µM 1.51E-4 ubiquinone biosynthesis & proteasome 55 1.45E-4
10 SGTC_1533 dihydroergotamine mesylate 3.53 29.4 µM 2.16E-4 DNA intercalators 19 2.06E-4
11 SGTC_2793 7325131 3.49 81.8 µM 2.51E-4 26 2.40E-4
12 SGTC_1455 4262-0120 3.45 131.0 µM 2.90E-4 plasma membrane duress 39 2.77E-4
13 SGTC_2284 7945075 3.44 39.2 µM 3.05E-4 mitochondrial processes 42 2.92E-4
14 SGTC_137 0438-0332 3.29 85.4 µM 5.26E-4 ubiquinone biosynthesis & proteasome 164 5.05E-4
15 SGTC_2364 9055074 3.27 200.0 µM 5.53E-4 39 5.30E-4
16 SGTC_2854 9024559 3.25 71.4 µM 5.95E-4 53 5.71E-4
17 SGTC_3146 9095609 3.13 49.5 µM 9.17E-4 50 8.80E-4
18 SGTC_2394 5221648 3.03 200.0 µM 0.00126 66 0.00121
19 SGTC_1352 1496-0991 3.03 99.0 µM 0.00128 tubulin folding & SWR complex 61 0.00123
20 SGTC_2006 4011487 3.02 200.0 µM 0.00130 endomembrane recycling 142 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.21E-15 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 2.41E-12 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.095 3.15E-8 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.095 3.89E-8 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.093 6.32E-8 YNL180C RHO5 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.093 6.62E-8 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 7.46E-8 YBR010W HHT1 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
0.090 1.62E-7 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.086 5.76E-7 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.086 6.45E-7 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.085 9.25E-7 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.084 1.26E-6 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.082 2.16E-6 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.080 3.19E-6 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.079 4.88E-6 YOR328W PDR10 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p