YPR008W / HAA1

Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR008W / HAA1

Click on Significant Values for Screen Details ID:SGTC_248|Compound:streptozotocin|FD-Score:3.09|P-value:6.69E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.14|P-value:5.98E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.41|P-value:1.95E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.99|P-value:2.50E-10 ID:SGTC_631|Compound:k072-0230|FD-Score:3.35|P-value:2.45E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.41|P-value:2.37E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.42|P-value:2.08E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.10|P-value:6.38E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.80|P-value:3.87E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.67|P-value:7.58E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.39|P-value:2.95E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:4.39|P-value:2.62E-6 ID:SGTC_1628|Compound:st004252|FD-Score:3.15|P-value:5.25E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.37|P-value:2.81E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.02|P-value:9.19E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.45|P-value:1.69E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.80|P-value:3.99E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.03|P-value:8.04E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.03|P-value:9.03E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.23|P-value:5.69E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.45|P-value:1.91E-6 ID:SGTC_2320|Compound:7373003|FD-Score:-3.70|P-value:6.78E-5 ID:SGTC_2376|Compound:9072922|FD-Score:-3.59|P-value:1.07E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.74|P-value:5.11E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.21|P-value:4.31E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.48|P-value:1.51E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.37|P-value:2.57E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.13|P-value:6.27E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.39|P-value:2.97E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.08|P-value:6.84E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.94|P-value:2.15E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.87|P-value:2.88E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:4.03E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.82|P-value:3.62E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-3.19|P-value:5.06E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.58|P-value:1.00E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.09|P-value:6.69E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.14|P-value:5.98E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.41|P-value:1.95E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.99|P-value:2.50E-10 ID:SGTC_631|Compound:k072-0230|FD-Score:3.35|P-value:2.45E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.41|P-value:2.37E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.42|P-value:2.08E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.10|P-value:6.38E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.80|P-value:3.87E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.67|P-value:7.58E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.39|P-value:2.95E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:4.39|P-value:2.62E-6 ID:SGTC_1628|Compound:st004252|FD-Score:3.15|P-value:5.25E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.37|P-value:2.81E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.02|P-value:9.19E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.45|P-value:1.69E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.80|P-value:3.99E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.03|P-value:8.04E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.03|P-value:9.03E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.23|P-value:5.69E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_2314|Compound:7727897|FD-Score:4.45|P-value:1.91E-6 ID:SGTC_2320|Compound:7373003|FD-Score:-3.70|P-value:6.78E-5 ID:SGTC_2376|Compound:9072922|FD-Score:-3.59|P-value:1.07E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.74|P-value:5.11E-5 ID:SGTC_2446|Compound:5162541|FD-Score:3.21|P-value:4.31E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.48|P-value:1.51E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.37|P-value:2.57E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.13|P-value:6.27E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.39|P-value:2.97E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.08|P-value:6.84E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.94|P-value:2.15E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.87|P-value:2.88E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:4.03E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.53|P-value:1.23E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.82|P-value:3.62E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-3.19|P-value:5.06E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.58|P-value:1.00E-4

Top fitness defect scores for YPR008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_369 0957-0393 5.99 4.5 µM 2.50E-10 cell wall signaling 4 1.03E-9
2 SGTC_2314 7727897 4.45 200.0 µM 1.91E-6 10 4.30E-6
3 SGTC_1347 1493-0251 4.41 600.0 nM 2.37E-6 mitochondrial response to ROS 11 5.24E-6
4 SGTC_1529 apigenin 4.39 74.0 µM 2.62E-6 25 5.76E-6
5 SGTC_1728 st035614 4.37 33.8 µM 2.81E-6 33 6.16E-6
6 SGTC_2307 7538926 4.23 6.3 µM 5.69E-6 32 1.19E-5
7 SGTC_2622 2-methoxyxanthone 3.94 59.9 µM 2.15E-5 20 4.11E-5
8 SGTC_2624 nerol 3.87 100.0 µM 2.88E-5 9 5.40E-5
9 SGTC_2822 7994718 3.82 71.4 µM 3.62E-5 20 6.67E-5
10 SGTC_1374 2889-5571 3.80 141.0 µM 3.87E-5 RSC complex & mRNA processing 44 7.10E-5
11 SGTC_2006 4011487 3.80 200.0 µM 3.99E-5 endomembrane recycling 86 7.31E-5
12 SGTC_2425 5628681 3.74 7.8 µM 5.11E-5 32 9.22E-5
13 SGTC_3220 9131269 3.58 49.5 µM 1.00E-4 18 1.73E-4
14 SGTC_2816 7982706 3.53 58.4 µM 1.23E-4 azole & statin 67 2.09E-4
15 SGTC_2486 5283202 3.48 22.4 µM 1.51E-4 53 2.53E-4
16 SGTC_3138 9097216 3.47 49.5 µM 1.57E-4 26 2.63E-4
17 SGTC_2000 st075254 3.45 36.4 µM 1.69E-4 22 2.81E-4
18 SGTC_367 0335-0881 3.41 7.1 µM 1.95E-4 ubiquinone biosynthesis & proteasome 105 3.22E-4
19 SGTC_2311 7694451 3.41 200.0 µM 1.98E-4 42 3.27E-4
20 SGTC_1741 st038134 3.38 10.2 µM 2.24E-4 51 3.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 5.16E-30 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.192 4.40E-29 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.176 8.72E-25 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.174 3.17E-24 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.170 2.81E-23 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.170 3.95E-23 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.164 1.19E-21 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.162 5.56E-21 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.159 1.52E-20 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.157 6.17E-20 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.146 1.58E-17 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.145 2.42E-17 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.145 3.88E-17 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.143 1.05E-16 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.142 1.30E-16 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication