Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.244 |
8.27E-47 |
YBR207W |
FTH1 |
hom |
Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress |
0.224 |
3.04E-39 |
YMR139W |
RIM11 |
hom |
Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress |
0.223 |
3.20E-39 |
YLR353W |
BUD8 |
hom |
Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole |
0.222 |
9.37E-39 |
YDL110C |
TMA17 |
hom |
Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion |
0.222 |
9.45E-39 |
YER067C-A_d |
YER067C-A_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W |
0.221 |
2.39E-38 |
YHR003C |
YHR003C |
hom |
Protein of unknown function, localized to the mitochondrial outer membrane |
0.221 |
2.58E-38 |
YKL131W_d |
YKL131W_d |
hom |
Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.216 |
9.16E-37 |
YMR147W_p |
YMR147W_p |
hom |
Putative protein of unknown function |
0.216 |
1.07E-36 |
YKL122C |
SRP21 |
het |
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm |
0.213 |
6.53E-36 |
YKL179C |
COY1 |
hom |
Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
0.213 |
9.16E-36 |
YFR027W |
ECO1 |
het |
Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress |
0.211 |
4.79E-35 |
YFL063W_d |
YFL063W_d |
hom |
Dubious open reading frame, based on available experimental and comparative sequence data |
0.202 |
3.38E-32 |
YLR016C |
PML1 |
hom |
Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p |
0.201 |
5.40E-32 |
YDL174C |
DLD1 |
hom |
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane |
0.200 |
1.72E-31 |
YLR205C |
HMX1 |
hom |
ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants |