YPR028W / YOP1

Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR028W / YOP1

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.55|P-value:1.93E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.20|P-value:6.86E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.82|P-value:6.62E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:4.26|P-value:1.01E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.38|P-value:3.57E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.20|P-value:6.89E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.34|P-value:6.91E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:3.49|P-value:2.37E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.13|P-value:1.41E-7 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.23|P-value:1.14E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.89|P-value:4.73E-7 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.79|P-value:7.27E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.14|P-value:8.44E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.33|P-value:4.26E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.85|P-value:5.77E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.28|P-value:4.94E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.20|P-value:6.73E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.35|P-value:3.98E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.29|P-value:8.72E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.54|P-value:1.95E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.98|P-value:3.03E-7 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.84|P-value:5.79E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.98|P-value:3.37E-5 ID:SGTC_1625|Compound:st003711|FD-Score:4.49|P-value:3.37E-6 ID:SGTC_1713|Compound:st033146|FD-Score:4.09|P-value:2.11E-5 ID:SGTC_1720|Compound:st037298|FD-Score:3.30|P-value:4.85E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.45|P-value:2.72E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.52|P-value:2.93E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.55|P-value:1.91E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.96|P-value:3.70E-5 ID:SGTC_1954|Compound:st077032|FD-Score:4.32|P-value:7.65E-6 ID:SGTC_1986|Compound:st071812|FD-Score:3.48|P-value:2.52E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.48|P-value:3.62E-6 ID:SGTC_2014|Compound:4013930|FD-Score:-3.73|P-value:8.81E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.36|P-value:3.89E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.22|P-value:6.28E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.63|P-value:1.39E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:5.02|P-value:2.49E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:3.96|P-value:3.73E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.37|P-value:6.01E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.19|P-value:6.96E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.44|P-value:4.14E-6 ID:SGTC_2809|Compound:7964133|FD-Score:4.59|P-value:2.12E-6 ID:SGTC_2954|Compound:9074818|FD-Score:-5.94|P-value:1.19E-9 ID:SGTC_3247|Compound:9135149|FD-Score:3.44|P-value:2.84E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.30|P-value:4.74E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.47|P-value:2.43E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.55|P-value:1.93E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.20|P-value:6.86E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.82|P-value:6.62E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:4.26|P-value:1.01E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.38|P-value:3.57E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.20|P-value:6.89E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.34|P-value:6.91E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:3.49|P-value:2.37E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.13|P-value:1.41E-7 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.23|P-value:1.14E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.89|P-value:4.73E-7 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.79|P-value:7.27E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.14|P-value:8.44E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.33|P-value:4.26E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.85|P-value:5.77E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.28|P-value:4.94E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.20|P-value:6.73E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.35|P-value:3.98E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.29|P-value:8.72E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.54|P-value:1.95E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.98|P-value:3.03E-7 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.84|P-value:5.79E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.98|P-value:3.37E-5 ID:SGTC_1625|Compound:st003711|FD-Score:4.49|P-value:3.37E-6 ID:SGTC_1713|Compound:st033146|FD-Score:4.09|P-value:2.11E-5 ID:SGTC_1720|Compound:st037298|FD-Score:3.30|P-value:4.85E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.45|P-value:2.72E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.52|P-value:2.93E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.55|P-value:1.91E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.96|P-value:3.70E-5 ID:SGTC_1954|Compound:st077032|FD-Score:4.32|P-value:7.65E-6 ID:SGTC_1986|Compound:st071812|FD-Score:3.48|P-value:2.52E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.48|P-value:3.62E-6 ID:SGTC_2014|Compound:4013930|FD-Score:-3.73|P-value:8.81E-5 ID:SGTC_2100|Compound:5377183|FD-Score:3.36|P-value:3.89E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.22|P-value:6.28E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.63|P-value:1.39E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:5.02|P-value:2.49E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:3.96|P-value:3.73E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.37|P-value:6.01E-6 ID:SGTC_2681|Compound:menadione|FD-Score:3.19|P-value:6.96E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.44|P-value:4.14E-6 ID:SGTC_2809|Compound:7964133|FD-Score:4.59|P-value:2.12E-6 ID:SGTC_2954|Compound:9074818|FD-Score:-5.94|P-value:1.19E-9 ID:SGTC_3247|Compound:9135149|FD-Score:3.44|P-value:2.84E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.11|P-value:9.43E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.30|P-value:4.74E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.47|P-value:2.43E-4

Top fitness defect scores for YPR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1032 k061-1018 5.13 98.7 µM 1.41E-7 6 1.47E-7
2 SGTC_2516 gossypol 5.02 71.5 µM 2.49E-7 7 2.60E-7
3 SGTC_1454 4239-0054 4.98 42.6 µM 3.03E-7 10 3.16E-7
4 SGTC_1041 0206-0046 4.89 107.0 µM 4.73E-7 17 4.92E-7
5 SGTC_2809 7964133 4.59 13.0 µM 2.12E-6 60S ribosome export 21 2.19E-6
6 SGTC_1779 st039427 4.52 55.0 µM 2.93E-6 13 3.03E-6
7 SGTC_1625 st003711 4.49 30.1 µM 3.37E-6 calcium & mitochondrial duress 24 3.48E-6
8 SGTC_1995 st072814 4.48 61.1 µM 3.62E-6 7 3.74E-6
9 SGTC_2668 2',4'-dihydroxychalcone 4.37 15.1 µM 6.01E-6 9 6.19E-6
10 SGTC_641 4092-0595 4.34 30.0 µM 6.91E-6 9 7.11E-6
11 SGTC_1954 st077032 4.32 68.9 µM 7.65E-6 13 7.87E-6
12 SGTC_1321 1326-2144 4.29 215.0 µM 8.72E-6 6 8.97E-6
13 SGTC_278 4092-0821 4.26 23.9 µM 1.01E-5 plasma membrane duress 34 1.03E-5
14 SGTC_1033 k072-0102 4.23 21.3 µM 1.14E-5 60S ribosome export 14 1.18E-5
15 SGTC_1713 st033146 4.09 12.8 µM 2.11E-5 22 2.16E-5
16 SGTC_1554 st069299 3.98 38.7 µM 3.37E-5 23 3.44E-5
17 SGTC_1899 st063254 3.96 59.6 µM 3.70E-5 13 3.78E-5
18 SGTC_2521 angolensin 3.96 13.4 µM 3.73E-5 10 3.81E-5
19 SGTC_1127 asiatic acid 3.85 681.4 nM 5.77E-5 25 5.89E-5
20 SGTC_160 3453-0671 3.82 289.7 µM 6.62E-5 43 6.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 9.45E-9 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.088 3.38E-7 YMR251W GTO3 hom Omega class glutathione transferase; putative cytosolic localization
0.086 5.52E-7 YMR086W SEG1 hom Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes
0.085 7.13E-7 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.085 9.31E-7 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.081 2.85E-6 YMR086C-A_d YMR086C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.66E-6 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.076 1.00E-5 YOR160W MTR10 het Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.074 1.62E-5 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.073 2.18E-5 YKL162C-A_d YKL162C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.51E-5 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
0.073 2.59E-5 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.072 2.73E-5 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.071 4.41E-5 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.070 4.59E-5 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance