YPR037C / ERV2

Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR037C / ERV2

Click on Significant Values for Screen Details ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.99|P-value:7.81E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.08|P-value:5.53E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.00|P-value:7.59E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.32|P-value:2.19E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.85|P-value:2.58E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.39|P-value:1.61E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.03|P-value:6.66E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.91|P-value:8.67E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.36|P-value:1.51E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.08|P-value:4.66E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:2.99|P-value:7.76E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.14|P-value:3.65E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.46|P-value:1.00E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.58|P-value:5.86E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.50|P-value:8.44E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.05|P-value:6.14E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.01|P-value:7.29E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.97|P-value:6.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.05|P-value:6.09E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-2.99|P-value:6.55E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.60|P-value:6.64E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-6.67|P-value:4.61E-13 ID:SGTC_2245|Compound:6637752|FD-Score:3.65|P-value:5.46E-5 ID:SGTC_2262|Compound:9014885|FD-Score:-5.95|P-value:9.28E-11 ID:SGTC_2320|Compound:7373003|FD-Score:-4.03|P-value:7.50E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-3.64|P-value:4.64E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.90|P-value:9.05E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.33|P-value:2.13E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.98|P-value:8.05E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.81|P-value:2.68E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.27|P-value:2.16E-4 ID:SGTC_2974|Compound:9094440|FD-Score:5.00|P-value:5.57E-8 ID:SGTC_2978|Compound:9011784|FD-Score:3.23|P-value:3.07E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.10|P-value:4.31E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.06|P-value:5.95E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.32|P-value:2.17E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.99|P-value:7.81E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.08|P-value:5.53E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.00|P-value:7.59E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.32|P-value:2.19E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:5.85|P-value:2.58E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.39|P-value:1.61E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.03|P-value:6.66E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.91|P-value:8.67E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.36|P-value:1.51E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.08|P-value:4.66E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:2.99|P-value:7.76E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.14|P-value:3.65E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.46|P-value:1.00E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.58|P-value:5.86E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.50|P-value:8.44E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.05|P-value:6.14E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.01|P-value:7.29E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.97|P-value:6.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.05|P-value:6.09E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-2.99|P-value:6.55E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.60|P-value:6.64E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-6.67|P-value:4.61E-13 ID:SGTC_2245|Compound:6637752|FD-Score:3.65|P-value:5.46E-5 ID:SGTC_2262|Compound:9014885|FD-Score:-5.95|P-value:9.28E-11 ID:SGTC_2320|Compound:7373003|FD-Score:-4.03|P-value:7.50E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-3.64|P-value:4.64E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.90|P-value:9.05E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.33|P-value:2.13E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.98|P-value:8.05E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.81|P-value:2.68E-5 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.27|P-value:2.16E-4 ID:SGTC_2974|Compound:9094440|FD-Score:5.00|P-value:5.57E-8 ID:SGTC_2978|Compound:9011784|FD-Score:3.23|P-value:3.07E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.10|P-value:4.31E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.06|P-value:5.95E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.32|P-value:2.17E-4

Top fitness defect scores for YPR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_369 0957-0393 5.85 4.5 µM 2.58E-10 cell wall signaling 5 2.52E-9
2 SGTC_2974 9094440 5.00 9.7 µM 5.57E-8 ergosterol biosynthesis 22 2.93E-7
3 SGTC_2719 novobiocin 3.81 32.6 µM 2.68E-5 4 7.00E-5
4 SGTC_2245 6637752 3.65 200.0 µM 5.46E-5 23 1.32E-4
5 SGTC_2022 5136654 3.60 200.0 µM 6.64E-5 27 1.57E-4
6 SGTC_1753 st043925 3.48 64.0 µM 1.12E-4 17 2.50E-4
7 SGTC_453 enantio-paf c16 3.39 10.0 µM 1.61E-4 198 3.44E-4
8 SGTC_2551 apiole 3.33 73.9 µM 2.13E-4 19 4.41E-4
9 SGTC_3246 9135460 3.32 33.0 µM 2.17E-4 12 4.50E-4
10 SGTC_367 0335-0881 3.32 7.1 µM 2.19E-4 ubiquinone biosynthesis & proteasome 118 4.53E-4
11 SGTC_2978 9011784 3.23 43.0 µM 3.07E-4 65 6.12E-4
12 SGTC_315 k915-0449 3.08 187.0 µM 5.53E-4 104 0.00103
13 SGTC_3215 9129942 3.06 49.5 µM 5.95E-4 35 0.00110
14 SGTC_1946 st076057 3.05 65.1 µM 6.09E-4 21 0.00113
15 SGTC_1312 1218-2183 3.05 165.0 µM 6.14E-4 29 0.00113
16 SGTC_659 k018-0002 3.03 107.0 µM 6.66E-4 55 0.00122
17 SGTC_1525 8-methoxypsoralen 3.01 92.5 µM 7.29E-4 DNA damage response 84 0.00132
18 SGTC_346 4513-0042 3.00 7.2 µM 7.59E-4 azole & statin 81 0.00137
19 SGTC_758 0868-0029 2.99 16.0 µM 7.76E-4 37 0.00140
20 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 2.99 44.4 nM 7.81E-4 DNA damage response 68 0.00141

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.06E-24 YDR445C_d YDR445C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.171 2.59E-23 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.167 2.62E-22 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.156 1.24E-19 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.150 2.54E-18 YDR109C_p YDR109C_p hom Putative kinase
0.148 6.79E-18 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.147 9.60E-18 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.145 3.88E-17 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.139 6.89E-16 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.139 7.47E-16 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.136 2.87E-15 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.135 3.35E-15 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 3.71E-15 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.131 3.46E-14 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.116 1.62E-11 YDR307W_p PMT7_p hom Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation