YPR058W / YMC1

Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR058W / YMC1

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-4.09|P-value:5.30E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.02|P-value:6.35E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.31|P-value:2.06E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.03|P-value:5.99E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.34|P-value:1.74E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.02|P-value:5.67E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.03|P-value:6.14E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.27|P-value:2.36E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.15|P-value:3.84E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.50|P-value:9.11E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.61|P-value:5.70E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.06|P-value:5.51E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.00|P-value:6.08E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.59|P-value:5.51E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.04|P-value:5.75E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.54|P-value:6.10E-7 ID:SGTC_2396|Compound:5342950|FD-Score:-3.29|P-value:1.93E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-3.24|P-value:2.40E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-2.96|P-value:7.17E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.04|P-value:5.23E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.64|P-value:4.99E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-2.97|P-value:6.73E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.39|P-value:1.44E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.08|P-value:4.94E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.05|P-value:5.70E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.53|P-value:7.22E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-3.38|P-value:1.34E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-5.47|P-value:1.95E-9 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.09|P-value:5.30E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:3.02|P-value:6.35E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.31|P-value:2.06E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.03|P-value:5.99E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.34|P-value:1.74E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.02|P-value:5.67E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.03|P-value:6.14E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.27|P-value:2.36E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.15|P-value:3.84E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.50|P-value:9.11E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.61|P-value:5.70E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.06|P-value:5.51E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.00|P-value:6.08E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.59|P-value:5.51E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.04|P-value:5.75E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.36|P-value:1.44E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.54|P-value:6.10E-7 ID:SGTC_2396|Compound:5342950|FD-Score:-3.29|P-value:1.93E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-3.24|P-value:2.40E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-2.96|P-value:7.17E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.04|P-value:5.23E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.64|P-value:4.99E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-2.97|P-value:6.73E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.39|P-value:1.44E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.08|P-value:4.94E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.05|P-value:5.70E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.53|P-value:7.22E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-3.38|P-value:1.34E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-5.47|P-value:1.95E-9

Top fitness defect scores for YPR058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1910 st062352 4.54 60.4 µM 6.10E-7 19 2.86E-6
2 SGTC_761 k216-0224 4.34 480.0 µM 1.74E-6 11 7.14E-6
3 SGTC_2893 9048488 3.64 26.0 µM 4.99E-5 fatty acid desaturase (OLE1) 27 1.36E-4
4 SGTC_1601 4'-hydroxyflavanone 3.61 55.5 µM 5.70E-5 RPP1 & pyrimidine depletion 43 1.53E-4
5 SGTC_1362 1611-0397 3.50 101.0 µM 9.11E-5 32 2.31E-4
6 SGTC_2762 leflunomide 3.46 42.1 µM 1.07E-4 50 2.67E-4
7 SGTC_2913 7966556 3.39 36.6 µM 1.44E-4 60S ribosome export 26 3.45E-4
8 SGTC_420 mitomycin C 3.31 81.9 mM 2.06E-4 33 4.73E-4
9 SGTC_1010 4112-3296 3.27 15.2 µM 2.36E-4 42 5.32E-4
10 SGTC_1891 st059073 3.22 26.2 µM 2.92E-4 TSC3-RPN4 44 6.42E-4
11 SGTC_1779 st039427 3.17 55.0 µM 3.49E-4 58 7.52E-4
12 SGTC_1288 0973-0013 3.15 65.5 µM 3.84E-4 42 8.17E-4
13 SGTC_2987 9018338 3.08 71.4 µM 4.94E-4 RPP1 & pyrimidine depletion 64 0.00102
14 SGTC_1630 st005209 3.06 31.3 µM 5.51E-4 68 0.00112
15 SGTC_3063 1327-0034 3.05 4.0 µM 5.70E-4 73 0.00116
16 SGTC_1753 st043925 3.04 64.0 µM 5.75E-4 37 0.00117
17 SGTC_726 3448-4391 3.03 34.2 µM 5.99E-4 50 0.00121
18 SGTC_883 0850-0245 3.03 24.6 µM 6.14E-4 cell wall 69 0.00124
19 SGTC_182 3448-4371 3.02 550.5 µM 6.35E-4 56 0.00127
20 SGTC_2337 9009472 2.83 200.0 µM 0.00126 95 0.00233

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.61E-13 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.111 1.41E-10 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.108 3.13E-10 YGR221C TOS2 hom Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
0.108 4.28E-10 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.106 9.02E-10 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.106 9.09E-10 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.105 1.20E-9 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.101 4.40E-9 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.098 1.53E-8 YDR390C UBA2 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.097 1.94E-8 YCR105W ADH7 hom NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
0.096 2.67E-8 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.093 6.30E-8 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.093 7.77E-8 YER179W DMC1 hom Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p
0.091 1.35E-7 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.090 1.98E-7 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1