YPR075C / OPY2

Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR075C / OPY2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.03|P-value:4.87E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.17|P-value:8.97E-9 ID:SGTC_110|Compound:0850-0284|FD-Score:3.35|P-value:1.36E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.21|P-value:2.38E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:2.97|P-value:6.21E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.67|P-value:3.30E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:2.90|P-value:7.99E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.39|P-value:8.96E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:2.94|P-value:7.00E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.00|P-value:5.50E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.34|P-value:1.17E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.05|P-value:5.22E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:4.11|P-value:3.80E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:5.49|P-value:1.15E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:3.49|P-value:7.29E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.67|P-value:3.30E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.49|P-value:7.20E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:2.94|P-value:6.86E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.04|P-value:4.71E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.89|P-value:8.26E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.01|P-value:5.24E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.15|P-value:3.11E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.81|P-value:1.73E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:2.88|P-value:8.77E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.32|P-value:1.50E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.41|P-value:1.05E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.09|P-value:4.38E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.94|P-value:9.21E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.51|P-value:6.75E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.16|P-value:2.95E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.27|P-value:1.86E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.99|P-value:2.86E-8 ID:SGTC_1637|Compound:st007924|FD-Score:-3.04|P-value:4.64E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.97|P-value:7.79E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.55|P-value:5.51E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.91|P-value:7.68E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.79|P-value:1.80E-5 ID:SGTC_1782|Compound:st039423|FD-Score:4.05|P-value:5.19E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:2.93|P-value:7.10E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-2.99|P-value:5.53E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.09|P-value:3.77E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.05|P-value:4.52E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.45|P-value:8.35E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.39|P-value:1.14E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.97|P-value:7.98E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.99|P-value:5.74E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.45|P-value:8.59E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.45|P-value:8.59E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.00|P-value:5.42E-4 ID:SGTC_2643|Compound:anethole|FD-Score:4.11|P-value:3.84E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.37|P-value:1.24E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:2.86|P-value:9.14E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.07|P-value:4.77E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.36|P-value:1.30E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.85|P-value:1.39E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.46|P-value:8.20E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.57|P-value:5.07E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.55|P-value:5.66E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.09|P-value:3.81E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.17|P-value:2.85E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.04|P-value:4.63E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.45|P-value:8.75E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.86|P-value:1.30E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.03|P-value:4.87E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.17|P-value:8.97E-9 ID:SGTC_110|Compound:0850-0284|FD-Score:3.35|P-value:1.36E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.21|P-value:2.38E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:2.97|P-value:6.21E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.67|P-value:3.30E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:2.90|P-value:7.99E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.39|P-value:8.96E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:2.94|P-value:7.00E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.00|P-value:5.50E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.34|P-value:1.17E-6 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.05|P-value:5.22E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:4.11|P-value:3.80E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:5.49|P-value:1.15E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:3.49|P-value:7.29E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.67|P-value:3.30E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.49|P-value:7.20E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:2.94|P-value:6.86E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.04|P-value:4.71E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.89|P-value:8.26E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.01|P-value:5.24E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.15|P-value:3.11E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.81|P-value:1.73E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:2.88|P-value:8.77E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.32|P-value:1.50E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.41|P-value:1.05E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.09|P-value:4.38E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.94|P-value:9.21E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.51|P-value:6.75E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.16|P-value:2.95E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.27|P-value:1.86E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.99|P-value:2.86E-8 ID:SGTC_1637|Compound:st007924|FD-Score:-3.04|P-value:4.64E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.97|P-value:7.79E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.55|P-value:5.51E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.91|P-value:7.68E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.79|P-value:1.80E-5 ID:SGTC_1782|Compound:st039423|FD-Score:4.05|P-value:5.19E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:2.93|P-value:7.10E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-2.99|P-value:5.53E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.09|P-value:3.77E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.05|P-value:4.52E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.45|P-value:8.35E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.39|P-value:1.14E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.97|P-value:7.98E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.99|P-value:5.74E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.45|P-value:8.59E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.45|P-value:8.59E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.00|P-value:5.42E-4 ID:SGTC_2643|Compound:anethole|FD-Score:4.11|P-value:3.84E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.37|P-value:1.24E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:2.86|P-value:9.14E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.07|P-value:4.77E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.36|P-value:1.30E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.85|P-value:1.39E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.46|P-value:8.20E-5 ID:SGTC_2838|Compound:9002687|FD-Score:3.57|P-value:5.07E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.55|P-value:5.66E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.09|P-value:3.81E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.17|P-value:2.85E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.04|P-value:4.63E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.45|P-value:8.75E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.86|P-value:1.30E-5

Top fitness defect scores for YPR075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_523 1934-0222 5.49 13.7 µM 1.15E-9 10 2.01E-8
2 SGTC_95 0471-0001 5.17 561.1 µM 8.97E-9 7 1.15E-7
3 SGTC_1628 st004252 4.99 77.7 µM 2.86E-8 9 3.07E-7
4 SGTC_430 0958-0115 4.39 16.4 µM 8.96E-7 18 5.71E-6
5 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 4.34 150.0 µM 1.17E-6 Golgi 35 7.18E-6
6 SGTC_507 nimesulide 4.11 162.0 µM 3.80E-6 14 1.95E-5
7 SGTC_2643 anethole 4.11 100.0 µM 3.84E-6 13 1.97E-5
8 SGTC_1142 3253-1408 4.09 9.8 µM 4.38E-6 8 2.20E-5
9 SGTC_2793 7325131 4.07 81.8 µM 4.77E-6 15 2.37E-5
10 SGTC_1782 st039423 4.05 80.6 µM 5.19E-6 20 2.54E-5
11 SGTC_501 nsc-95397 4.05 161.0 µM 5.22E-6 14 2.55E-5
12 SGTC_1720 st037298 3.97 9.5 µM 7.79E-6 34 3.59E-5
13 SGTC_2032 5185112 3.97 26.0 µM 7.98E-6 10 3.66E-5
14 SGTC_1172 0370-0043 3.94 85.0 µM 9.21E-6 25 4.14E-5
15 SGTC_2821 7996764 3.85 71.4 µM 1.39E-5 45 5.88E-5
16 SGTC_826 1683-5028 3.81 118.0 µM 1.73E-5 19 7.08E-5
17 SGTC_589 1227-0070 3.67 34.1 µM 3.30E-5 34 1.22E-4
18 SGTC_260 nsc-65238 3.67 4.0 µM 3.30E-5 endomembrane recycling 24 1.23E-4
19 SGTC_2838 9002687 3.57 71.4 µM 5.07E-5 fatty acid desaturase (OLE1) 31 1.77E-4
20 SGTC_1725 st036284 3.55 20.6 µM 5.51E-5 45 1.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 7.62E-13 YIL100W_d YIL100W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
0.104 1.36E-9 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.100 7.58E-9 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.085 7.49E-7 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.080 3.31E-6 YLR438W CAR2 hom L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
0.079 4.60E-6 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.078 5.92E-6 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.078 5.88E-6 YJR051W OSM1 hom Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
0.074 1.70E-5 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.074 1.99E-5 YER103W SSA4 hom Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
0.073 2.44E-5 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.072 2.78E-5 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.069 6.59E-5 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.068 7.32E-5 YBR056W-A_p YBR056W-A_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B
0.067 1.07E-4 YLR325C RPL38 hom Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog