YPR079W / MRL1

Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR079W / MRL1

Click on Significant Values for Screen Details ID:SGTC_306|Compound:1672-3436|FD-Score:-3.50|P-value:8.42E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.61|P-value:5.61E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-2.88|P-value:9.89E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.25|P-value:2.54E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.13|P-value:1.92E-8 ID:SGTC_876|Compound:0720-0963|FD-Score:3.56|P-value:7.02E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:2.90|P-value:9.69E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.13|P-value:3.98E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.93|P-value:6.45E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.14|P-value:4.65E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.43|P-value:9.76E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:5.06|P-value:3.04E-8 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:2.96|P-value:7.77E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.38|P-value:1.47E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-2.94|P-value:7.98E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.22|P-value:2.80E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.27|P-value:2.33E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.55|P-value:6.75E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-3.43|P-value:1.12E-4 ID:SGTC_2696|Compound:st077691|FD-Score:2.94|P-value:8.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.53|P-value:8.00E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-4.10|P-value:5.22E-6 ID:SGTC_3217|Compound:9129673|FD-Score:-3.20|P-value:2.90E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.99|P-value:6.44E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:-3.50|P-value:8.42E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.61|P-value:5.61E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-2.88|P-value:9.89E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.25|P-value:2.54E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.13|P-value:1.92E-8 ID:SGTC_876|Compound:0720-0963|FD-Score:3.56|P-value:7.02E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:2.90|P-value:9.69E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.13|P-value:3.98E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.93|P-value:6.45E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.14|P-value:4.65E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.43|P-value:9.76E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:5.06|P-value:3.04E-8 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:2.96|P-value:7.77E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.38|P-value:1.47E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-2.94|P-value:7.98E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.22|P-value:2.80E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.27|P-value:2.33E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.55|P-value:6.75E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-3.43|P-value:1.12E-4 ID:SGTC_2696|Compound:st077691|FD-Score:2.94|P-value:8.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.53|P-value:8.00E-5 ID:SGTC_3131|Compound:9127911|FD-Score:-4.10|P-value:5.22E-6 ID:SGTC_3217|Compound:9129673|FD-Score:-3.20|P-value:2.90E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.99|P-value:6.44E-4

Top fitness defect scores for YPR079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_710 3448-4187 5.13 58.0 µM 1.92E-8 fatty acid desaturase (OLE1) 25 1.42E-7
2 SGTC_1568 digitonin 5.06 820.0 nM 3.04E-8 sphingolipid biosynthesis & PDR1 17 2.12E-7
3 SGTC_1248 0469-0687 4.93 58.6 µM 6.45E-8 11 4.10E-7
4 SGTC_1364 1653-0028 4.14 37.6 µM 4.65E-6 15 1.73E-5
5 SGTC_440 fluspirilene 3.61 35.1 µM 5.61E-5 23 1.54E-4
6 SGTC_876 0720-0963 3.56 56.8 µM 7.02E-5 26 1.87E-4
7 SGTC_2926 9010726 3.53 65.2 µM 8.00E-5 43 2.10E-4
8 SGTC_2215 7188065 3.38 200.0 µM 1.47E-4 16 3.59E-4
9 SGTC_2330 7979373 3.27 200.0 µM 2.33E-4 60S ribosome export 58 5.37E-4
10 SGTC_638 3970-0837 3.25 4.1 µM 2.54E-4 72 5.80E-4
11 SGTC_2329 6138490 3.22 200.0 µM 2.80E-4 67 6.30E-4
12 SGTC_2120 5538279 3.19 152.0 µM 3.18E-4 37 7.07E-4
13 SGTC_970 1315-0089 3.13 19.5 µM 3.98E-4 RSC & ERG11 57 8.59E-4
14 SGTC_1599 8-chlro-1-tetrahydronorharmanone 2.96 90.6 µM 7.77E-4 88 0.00155
15 SGTC_2696 st077691 2.94 74.3 µM 8.25E-4 79 0.00163
16 SGTC_966 1300-0360 2.90 30.2 µM 9.69E-4 heme requiring 76 0.00188
17 SGTC_2288 7946289 2.87 167.3 µM 0.00108 86 0.00207
18 SGTC_1227 3909-8010 2.82 46.6 µM 0.00127 75 0.00238
19 SGTC_1570 verbenone 2.78 133.0 µM 0.00149 77 0.00274
20 SGTC_686 1319-0111 2.77 510.0 µM 0.00154 60S ribosome export 84 0.00283

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 5.30E-22 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.158 3.14E-20 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.138 8.41E-16 YHR014W SPO13 hom Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
0.121 1.85E-12 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.111 1.01E-10 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.110 1.73E-10 YPL247C_p YPL247C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
0.109 2.75E-10 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.103 1.85E-9 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.102 2.92E-9 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.102 3.59E-9 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.095 3.61E-8 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.094 5.50E-8 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.093 6.10E-8 YOL109W ZEO1 hom Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
0.091 1.42E-7 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.089 2.12E-7 YDR541C_p YDR541C_p hom Putative dihydrokaempferol 4-reductase