YPR099C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR099C / YPR099C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.44|P-value:2.19E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.75|P-value:2.27E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.84|P-value:1.66E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.71|P-value:1.15E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.92|P-value:1.24E-13 ID:SGTC_118|Compound:0083-0097|FD-Score:3.33|P-value:8.87E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.74|P-value:2.30E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.35|P-value:8.50E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.48|P-value:5.53E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.79|P-value:1.99E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.66|P-value:5.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.73|P-value:4.44E-13 ID:SGTC_195|Compound:4234-0266|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:1.27E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.25|P-value:3.65E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:8.34|P-value:6.57E-15 ID:SGTC_385|Compound:1494-0393|FD-Score:4.04|P-value:8.19E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:4.09|P-value:6.65E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.25|P-value:1.13E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.55|P-value:7.69E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.80|P-value:1.89E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.44|P-value:1.71E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.74|P-value:4.98E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:3.84|P-value:1.67E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.78|P-value:1.66E-10 ID:SGTC_911|Compound:3456-4043|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.28|P-value:3.24E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.43|P-value:3.52E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.33|P-value:2.69E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.68|P-value:6.63E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.36|P-value:3.20E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.45|P-value:6.11E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.54|P-value:4.58E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.60|P-value:9.13E-6 ID:SGTC_1731|Compound:st035964|FD-Score:-4.66|P-value:1.43E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-4.26|P-value:6.58E-5 ID:SGTC_1742|Compound:st038235|FD-Score:5.36|P-value:3.22E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.31|P-value:9.58E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.82|P-value:3.10E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.31|P-value:2.87E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.84|P-value:1.66E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.94|P-value:1.16E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.79|P-value:4.18E-6 ID:SGTC_2488|Compound:5268135|FD-Score:4.00|P-value:9.47E-5 ID:SGTC_2526|Compound:patulin|FD-Score:7.33|P-value:5.89E-12 ID:SGTC_2680|Compound:butyl paraben|FD-Score:4.20|P-value:4.48E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-8.75|P-value:1.11E-15 ID:SGTC_2896|Compound:9052656|FD-Score:-4.11|P-value:1.15E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.66|P-value:5.42E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.72|P-value:4.41E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.44|P-value:2.19E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.75|P-value:2.27E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.84|P-value:1.66E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.71|P-value:1.15E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.92|P-value:1.24E-13 ID:SGTC_118|Compound:0083-0097|FD-Score:3.33|P-value:8.87E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.74|P-value:2.30E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.35|P-value:8.50E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.48|P-value:5.53E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.79|P-value:1.99E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.66|P-value:5.31E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.73|P-value:4.44E-13 ID:SGTC_195|Compound:4234-0266|FD-Score:3.42|P-value:6.83E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:1.27E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.25|P-value:3.65E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:8.34|P-value:6.57E-15 ID:SGTC_385|Compound:1494-0393|FD-Score:4.04|P-value:8.19E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:4.09|P-value:6.65E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.25|P-value:1.13E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.55|P-value:7.69E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.80|P-value:1.89E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.44|P-value:1.71E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.74|P-value:4.98E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:3.84|P-value:1.67E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.78|P-value:1.66E-10 ID:SGTC_911|Compound:3456-4043|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.28|P-value:3.24E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.43|P-value:3.52E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.33|P-value:2.69E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.68|P-value:6.63E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.36|P-value:3.20E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.45|P-value:6.11E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.54|P-value:4.58E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.60|P-value:9.13E-6 ID:SGTC_1731|Compound:st035964|FD-Score:-4.66|P-value:1.43E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-4.26|P-value:6.58E-5 ID:SGTC_1742|Compound:st038235|FD-Score:5.36|P-value:3.22E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.31|P-value:9.58E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.82|P-value:3.10E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.31|P-value:2.87E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.84|P-value:1.66E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.94|P-value:1.16E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.79|P-value:4.18E-6 ID:SGTC_2488|Compound:5268135|FD-Score:4.00|P-value:9.47E-5 ID:SGTC_2526|Compound:patulin|FD-Score:7.33|P-value:5.89E-12 ID:SGTC_2680|Compound:butyl paraben|FD-Score:4.20|P-value:4.48E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-8.75|P-value:1.11E-15 ID:SGTC_2896|Compound:9052656|FD-Score:-4.11|P-value:1.15E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.66|P-value:5.42E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.72|P-value:4.41E-4

Top fitness defect scores for YPR099C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.00 5.3 µM 1.27E-20 195 6.84E-24
2 SGTC_310 1273-0058 8.34 1.1 µM 6.57E-15 mitochondrial stress 78 3.84E-17
3 SGTC_63 0099-0242 7.92 26.7 µM 1.24E-13 mitochondrial stress 12 1.22E-15
4 SGTC_173 1273-0061 7.73 2.7 µM 4.44E-13 mitochondrial stress 73 5.52E-15
5 SGTC_2526 patulin 7.33 37.6 µM 5.89E-12 18 1.16E-13
6 SGTC_908 3448-7491 6.78 47.7 µM 1.66E-10 mitochondrial stress 31 5.89E-12
7 SGTC_10 0279-0212 5.44 42.6 µM 2.19E-7 TRP & mitochondrial translation 42 2.72E-8
8 SGTC_1188 1403-0014 5.36 4.6 µM 3.20E-7 mitochondrial stress 22 4.23E-8
9 SGTC_1742 st038235 5.36 28.9 µM 3.22E-7 mitochondrial stress 65 4.26E-8
10 SGTC_2472 5377652 4.79 49.4 µM 4.18E-6 TRP & mitochondrial translation 35 8.52E-7
11 SGTC_767 0929-0023 4.74 86.0 µM 4.98E-6 TRP & mitochondrial translation 43 1.05E-6
12 SGTC_1181 1222-0449 4.68 220.0 µM 6.63E-6 14 1.46E-6
13 SGTC_1730 st033808 4.60 45.1 µM 9.13E-6 19 2.12E-6
14 SGTC_717 1532-0246 4.44 73.2 µM 1.71E-5 Golgi 23 4.42E-6
15 SGTC_1133 3473-0247 4.33 50.0 µM 2.69E-5 RSC complex & mRNA processing 36 7.46E-6
16 SGTC_2232 chlorophetanol 4.31 41.5 µM 2.87E-5 TRP & mitochondrial translation 106 8.07E-6
17 SGTC_918 glabranin 4.28 770.7 nM 3.24E-5 24 9.27E-6
18 SGTC_275 trichlorophene 4.25 5.7 µM 3.65E-5 mitochondrial stress 211 1.06E-5
19 SGTC_2680 butyl paraben 4.20 22.2 µM 4.48E-5 amide catabolism 5 1.35E-5
20 SGTC_559 1550-0661 4.09 158.0 µM 6.65E-5 6 2.14E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.426 5.25E-147 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.423 2.69E-145 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.407 1.34E-133 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.406 2.04E-133 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.405 2.42E-132 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.404 1.85E-131 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.403 2.60E-131 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.401 1.49E-129 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.394 8.46E-125 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.394 1.24E-124 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.393 3.23E-124 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.392 1.10E-123 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.391 6.70E-123 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.387 3.38E-120 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.386 3.70E-119 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth