HIPHOP chemogenomics database
YPR103W / PRE2 
Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPR103W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.358 | 4.32E-102 | YFR050C | PRE4 | het | Beta 7 subunit of the 20S proteasome |
| 0.343 | 6.22E-93 | YBL041W | PRE7 | het | Beta 6 subunit of the 20S proteasome |
| 0.301 | 3.56E-71 | YOL038W | PRE6 | het | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
| 0.295 | 1.82E-68 | YGL011C | SCL1 | het | Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria |
| 0.295 | 2.52E-68 | YMR314W | PRE5 | het | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
| 0.285 | 8.43E-64 | YER012W | PRE1 | het | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
| 0.282 | 2.16E-62 | YER094C | PUP3 | het | Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 |
| 0.267 | 1.08E-55 | YML092C | PRE8 | het | Alpha 2 subunit of the 20S proteasome |
| 0.265 | 7.18E-55 | YOR362C | PRE10 | het | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
| 0.223 | 3.71E-39 | YGR253C | PUP2 | het | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
| 0.219 | 9.36E-38 | YKL203C | TOR2 | het | PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication |
| 0.216 | 7.45E-37 | YDL007W | RPT2 | het | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle |
| 0.207 | 7.46E-34 | YJL001W | PRE3 | het | Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides |
| 0.184 | 7.88E-27 | YDR023W | SES1 | het | Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p |
| 0.172 | 9.88E-24 | YLR021W | IRC25 | hom | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |