YPR114W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR114W / YPR114W

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.82|P-value:1.63E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.56|P-value:4.83E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.82|P-value:1.65E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:5.01|P-value:1.24E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.50|P-value:4.94E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.40|P-value:1.95E-7 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.72|P-value:2.31E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.43|P-value:6.19E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.92|P-value:1.15E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.46|P-value:1.41E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.73|P-value:4.44E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.38|P-value:8.70E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.83|P-value:1.57E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.58|P-value:3.72E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.01|P-value:8.24E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.73|P-value:2.22E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.54|P-value:4.30E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.68|P-value:2.66E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.40|P-value:8.07E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.04|P-value:7.25E-5 ID:SGTC_1708|Compound:st033234|FD-Score:4.60|P-value:7.72E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.35|P-value:2.60E-5 ID:SGTC_1786|Compound:berberine|FD-Score:7.47|P-value:1.20E-12 ID:SGTC_1847|Compound:st056231|FD-Score:4.53|P-value:1.04E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.74|P-value:2.13E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.38|P-value:2.34E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.75|P-value:2.11E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.79|P-value:4.23E-6 ID:SGTC_2265|Compound:7929201|FD-Score:3.48|P-value:5.28E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-4.97|P-value:1.86E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.95|P-value:1.67E-6 ID:SGTC_2445|Compound:5742597|FD-Score:3.61|P-value:3.45E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.33|P-value:8.54E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.34|P-value:2.76E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.95|P-value:1.02E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.38|P-value:8.61E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.28|P-value:9.96E-4 ID:SGTC_3184|Compound:9108758|FD-Score:4.03|P-value:7.57E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:3.82|P-value:1.63E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.56|P-value:4.83E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.82|P-value:1.65E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:5.01|P-value:1.24E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.50|P-value:4.94E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.40|P-value:1.95E-7 ID:SGTC_396|Compound:dithiazanine|FD-Score:3.72|P-value:2.31E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.43|P-value:6.19E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.92|P-value:1.15E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.46|P-value:1.41E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.73|P-value:4.44E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.38|P-value:8.70E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.83|P-value:1.57E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.58|P-value:3.72E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.01|P-value:8.24E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.73|P-value:2.22E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.54|P-value:4.30E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.68|P-value:2.66E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.40|P-value:8.07E-4 ID:SGTC_1686|Compound:st019653|FD-Score:4.04|P-value:7.25E-5 ID:SGTC_1708|Compound:st033234|FD-Score:4.60|P-value:7.72E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.35|P-value:2.60E-5 ID:SGTC_1786|Compound:berberine|FD-Score:7.47|P-value:1.20E-12 ID:SGTC_1847|Compound:st056231|FD-Score:4.53|P-value:1.04E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.74|P-value:2.13E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.38|P-value:2.34E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.75|P-value:2.11E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.79|P-value:4.23E-6 ID:SGTC_2265|Compound:7929201|FD-Score:3.48|P-value:5.28E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-4.97|P-value:1.86E-6 ID:SGTC_2411|Compound:st077133|FD-Score:4.95|P-value:1.67E-6 ID:SGTC_2445|Compound:5742597|FD-Score:3.61|P-value:3.45E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.33|P-value:8.54E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.34|P-value:2.76E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.95|P-value:1.02E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.38|P-value:8.61E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.28|P-value:9.96E-4 ID:SGTC_3184|Compound:9108758|FD-Score:4.03|P-value:7.57E-5

Top fitness defect scores for YPR114W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1786 berberine 7.47 21.6 µM 1.20E-12 60S ribosome export 4 3.90E-14
2 SGTC_385 1494-0393 5.40 12.4 µM 1.95E-7 4 3.28E-8
3 SGTC_198 3454-2873 5.01 16.2 µM 1.24E-6 60S ribosome export 4 2.66E-7
4 SGTC_2411 st077133 4.95 39.9 µM 1.67E-6 RNA pol III & RNase P/MRP 13 3.75E-7
5 SGTC_485 niflumic acid 4.73 177.0 µM 4.44E-6 4 1.13E-6
6 SGTC_1708 st033234 4.60 31.8 µM 7.72E-6 8 2.12E-6
7 SGTC_1847 st056231 4.53 15.0 µM 1.04E-5 23 2.97E-6
8 SGTC_468 gf-109203x 4.46 121.0 µM 1.41E-5 amide catabolism 2 4.19E-6
9 SGTC_1686 st019653 4.04 115.5 µM 7.25E-5 mitochondrial processes 10 2.68E-5
10 SGTC_3184 9108758 4.03 49.5 µM 7.57E-5 5 2.81E-5
11 SGTC_1174 0739-0097 4.01 51.1 µM 8.24E-5 redox potentiating 32 3.09E-5
12 SGTC_2695 st077686 3.95 52.0 µM 1.02E-4 36 3.92E-5
13 SGTC_444 curcumin 3.92 90.4 µM 1.15E-4 iron homeostasis 27 4.50E-5
14 SGTC_711 k292-0785 3.83 179.0 µM 1.57E-4 DNA intercalators 26 6.40E-5
15 SGTC_23 0213-0011 3.82 40.0 µM 1.63E-4 copper-dependent oxidative stress 31 6.71E-5
16 SGTC_29 0299-0004 3.82 13.0 µM 1.65E-4 31 6.78E-5
17 SGTC_1951 sophoraflavanone G 3.75 9.2 µM 2.11E-4 RNA processing & uracil transport 28 8.95E-5
18 SGTC_1852 st056254 3.74 31.4 µM 2.13E-4 13 9.03E-5
19 SGTC_1424 4048-1941 3.73 275.0 µM 2.22E-4 31 9.50E-5
20 SGTC_396 dithiazanine 3.72 1.2 µM 2.31E-4 10 9.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.39E-9 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.100 7.25E-9 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.096 2.83E-8 YER111C SWI4 hom DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
0.091 1.46E-7 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.079 5.30E-6 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.077 8.06E-6 YGL129C RSM23 hom Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
0.076 9.15E-6 YKR017C HEL1 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
0.075 1.24E-5 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.073 2.19E-5 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.073 2.36E-5 YPR197C_d YPR197C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.72E-5 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.071 3.87E-5 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.070 4.80E-5 YKR070W_p YKR070W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.070 5.67E-5 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.070 5.58E-5 YBR268W MRPL37 hom Mitochondrial ribosomal protein of the large subunit